Sometimes genes that are supposed to
signal cell death at the appropriate time fail to turn on.
Not exact matches
When Hong further boosted MAPK
signals and DNA damage in the tumor
cells, she found that she could intensify tumor
cell death.
For some years now, a new class of drugs called antibody - drug conjugates (ADCs) have been used, which work in two ways: they consist of an antibody that binds selectively to the tumor
cell receptor and interrupts the
signal to propagate; they also act as a transport vehicle for a chemical substance that enters the cancer
cells with the antibody and triggers their
death.
When this level was high enough, stress
signals can lead to DNA damage and then trigger a form of
cell death called parthanatos.
The exceptional cancer
cells that escape the astrocytes do so by producing a protein called Serpin, which acts as a sort of antidote to the
death signals fired at them by nearby astrocytes.
This suggests that «the python intestine may represent a valuable model for studying the interactions of metabolism with the regulation of
cell division /
death and WNT
signaling relevant to cancer,» the researchers said.
The new chimera interferes with HER2 and HER3
signaling and ultimately leads to cancer
cell death, as shown in the group's recent publication in Molecular Therapy: Nucleic Acids.
(In contrast, cancer
cells fail to respond to the environmental
signals that regulate
cell death.
It can sense the presence of DNA damage,
signal to other proteins that damage exists, aid in the repair of damage and stimulate
cell death if the damage can not be repaired.
Both discoveries came from studies of mitochondria, the powerhouses of the
cell that burn nutrients for energy but also play a key role in
signaling,
cell death and growth.
This has a positive effect initially, but as
cell death progresses further, the correct
signal may almost disappear.
It has long been known that
cells tag proteins for degradation by labelling them with ubiquitin, a
signal described as «the molecular kiss of
death.»
The scientists also found that endothelial
cells themselves give the
signal for their own
death: To do this, the vascular wall cells have a receptor molecule called Death Receptor 6 (DR6) on their sur
death: To do this, the vascular wall
cells have a receptor molecule called
Death Receptor 6 (DR6) on their sur
Death Receptor 6 (DR6) on their surface.
The mechanism that becomes effective is a destructive
signal sent by the antibody to the inside of the cancer
cell and initiates its
death.
The researchers studied the brains of people who died from HD and those who died of other, non-neurological diseases and identified a very specific genetic
signal that strongly correlates disease severity and extent of neuronal, or brain
cell death.
As described in Nature, pyroptosis ensues as immune
cells rupture and release inflammatory
signals that attract still more
cells to repeat the
death cycle.
In fact, researchers at Stanford are already collaborating on initial clinical trials of an antibody that blocks cancer
cells from displaying one such
death - evading
signal — a molecule called CD47.
The team identified a critical pathway of molecular
signals which throw a lifeline to cancer
cells, enabling them to survive even though they contain vast DNA errors which would usually trigger
cell death.
«We're excited to be contributing to a growing area of study of how astrocytes contribute to neurodegeneration, and to have uncovered a role for NO as a neuronal
cell death signaling molecule,» said corresponding author Mel B. Feany, MD, PhD, a senior pathologist in the BWH Department of Pathology.
The researchers injured the mice retinas with a toxin that causes
cell death in retinal ganglion
cells and interneurons, another type of retinal
cell whose job it is to transmit
signals from photoreceptors to the brain.
Retinal
cell death can be induced by phagocytic immune
cells that infiltrate the tissue in response to injury or infection, but the molecular
signals that trigger phagocyte invasion are largely unknown.
One aspect of their work studies how
cell signaling pathways, such as those that initiate
cell growth or
death, are affected by the nanostructures and microstructures of implant materials such as titanium.
But what scientists did not know is how the mutations trigger a molecular
signaling pathway that leads to the
death of photoreceptor
cells.
The team led by Rory Fisher, Ph.D., professor of pharmacology in the UI Carver College of Medicine, has identified a protein called RGS6 (regulator of G protein
signaling 6) that acts through two separate mechanisms to control alcohol - seeking behavior and alcohol - induced
cell death in heart, liver, and other organs.
The authors conclude that their six hallmarks — sustained proliferative
signaling, evading growth suppression, resisting
cell death, replicative immortality, induction of angiogenesis, and invasion / metastasis — continue to provide a useful conceptual framework for understanding the biology of cancer.
At the molecular level, he is discovering how mechanical forces
signal gene expression to cause
cell growth, migration and
cell death.
Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3
signaling pathway induced by LPLs secretion of IL - 22 — Qihang Hou —
Cell Death and Differentiation
From zero to sixty:
cell death signaling in the city that never sleeps.
Pro-apoptotic bax and bak control beta -
cell death and early endoplasmic reticulum stress
signalling.
We are identifying and characterizing the
signaling molecules that control the interphase between
cell survival and
death cascades.
15:00 Paolo Pinton, Section of General Pathology, Department of Experimental and Diagnostic Medicine, Telethon Center for
Cell Imaging and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Italy: «Mitochondrial Ca2 +
signals: message of life and
death.»
Insulin - like growth factor - I blocks Bcl - 2 interacting mediator of
cell death (Bim) induction and intrinsic
death signaling in cerebellar granule neurons.
Once inside, the virus's DNA acts as a danger
signal that activates a protein called caspase 1, which can initiate
cell death in several ways, including opening pores that disturb the
cell's ion balance and releasing inflammatory
signals that recruit other immune
cells.
Our present studies are focusing on the molecular interactions which prevent excessive T
cell death after the initial period of clonal expansion and which are essential for promoting late T
cell division and providing long - term survival
signals.
When Ras genes are mutated,
cells grow uncontrollably and evade
death signals.
Follin - Arbelet V, Torgersen ML, Naderi EH, Misund K, Sundan A, Blomhoff HK
Death of multiple myeloma
cells induced by cAMP -
signaling involves downregulation of Mcl - 1 via the JAK / STAT pathway Cancer Lett (in press) PubMed 23454584
In glaucoma, EDN
signaling increases in retinal
cells before any damage occurs, and blocking it lessens
cell death.
The King Lab has pioneered the use of selectin proteins to deliver apoptosis
death signals to tumor
cells in flowing blood, and to deliver therapeutic cargo (e.g., siRNA, chemotherapeutics) encapsulated in nanoscale liposomes.
The A. queenslandica genome allows us to assess systematically the origin of the six hallmarks of metazoan multicellularity: (1) regulated
cell cycling and growth; (2) programmed
cell death; (3)
cell —
cell and
cell — matrix adhesion; (4) developmental
signalling and gene regulation; (5) allorecognition and innate immunity; and (6) specialization of
cell types.
Inhibition of Notch
signaling reduces proliferation of stem
cells, induces
cell death, and down - regulates non-canonical Wnt5a, suggesting that the Notch pathway contributes to maintenance and motility of the stem
cells.
This will lead to detailed new information about exactly what molecular
signals are provoked and how they may contribute to
cell death.
Tribbles normally binds and blocks the action of AKT, an insulin
signaling protein directly involved in
cell death and proliferation — and the tribbles genetic variants bound more strongly to AKT, thereby blocking proliferation and promoting
cell death.
Interestingly, fluid shear stress also modulates how tumor
cells respond to apoptosis
death signals in the bloodstream.
By identifying, activating and inhibiting critical
signaling nodes in
cells, the scientists seek to better understand how these drive responses such as
cell death and differentiation.
Calcitonin Gene - Related Peptide Enhances the Expression of
Signaling Molecules of the Wnt 7b / Beta - Catenin Pathway in Rat Type II Alveolar Epithelial
Cells Under Hyperoxia Hyperoxic lung injury is characterized by epithelial
cell death and leukocyte infiltration / inflammation in the lung.
Read about the monitoring of apoptosis and necrosis in real time using the CLARIOstar's ACU feature, that maintains the appropriate O2 and CO2 environment for
cells, while the RealTime - GloTM Annexin V Apoptosis and Necrosis Assay measures
cell death using luminescence and fluorescent
signals.
Cancer is known to develop through ten independent causative factors including DNA damage, chronic inflammation, cellular
signaling dysfunction, abnormal
cell death and metastasis.
One way that curcumin inhibits cancer is by restoring normal
cell -
death signalling in a cancerous
cell.
Normal
cell -
death signalling is mediated by various
cell proteins: some
signal the
cell to survive and some
signal the
cell to die.