Sentences with phrase «signal components for»

Not exact matches

It said that Apple had told its iPhone X suppliers that it only wanted about 40 % of the components it had originally ordered, signaling weak initial demand for the device.

Generally speaking, joint market action in Treasury yields, credit spreads, commodities, and market internals provide the earliest signal of potential economic strains, followed by the new orders and production components of regional purchasing managers indices and Fed surveys, followed by real sales, followed by real production, followed by real income, followed by new claims for unemployment, and confirmed much later by payroll employment.

Although much less research exists on monk fruit and its components, preliminary studies show promise for improving insulin signaling by protecting the pancreatic insulin - releasing cells from oxidative stress (3, 4).

For the teams out West, it signals that the Warriors just added another component player to the rotation that may yield big dividends in the postseason.

ARA is a component of all cells and important for cell signaling.

The semiconductor gallium arsenide (GaAs) is widely used, for instance in infrared remote controls, the high - frequency components of mobile phones and for converting electrical signals into light for fibre optical transmission, as well as in solar panels for deployment in spacecraft.

For example, to tease out what various sound signals might mean, the researchers had to figure out how kelp tissues respond to sound (turns out that it's highly dependent on alginate content, a gummy cell wall component of kelp).

Steve: So when you see alcoholism in a cluster in a family group, that's a signal to you that even though there might be an environmental component, perhaps it's at least worth looking for a genetic component?

The authors hypothesize that these activities are components of cellular reconfigurations that are involved in processing communication signals essential for social organization.

Signals that have the fewest component frequencies, like those used for medical imaging, will see the biggest speed gains, but more complex tasks, such as video file compression, should get a substantial boost as well.

Chloroplast, the compartment responsible for plant photosynthesis, is a key component of this signaling pathway.

The target for ibrutinib, an enzyme called Bruton's tyrosine kinase (BTK), is a key component of B - cell receptor signaling.

Scaffold proteins offer a simple, flexible strategy for regulating selectivity in pathways, shaping output behaviors, and achieving new responses from preexisting signaling components.

«For instance, when components are smaller, it means the signals they transmit don't need to go as far, which increases their operating speed.

For the first time, researchers have shown that cultured picocyanobacteria, Synechococcus and Prochlorococcus, found in the open ocean release fluorescent components that closely match these typical fluorescent signals found in oceanic environments.

These technologies and components include innovative audio encoding methods, as well as server solutions for coding and generating digital radio transmission signals and software components for radio receiver devices.

«Two components of the pathway, the phosphatase PTPD2 and the lipid PA, are together required for HER2 signaling to function in mammary epithelial cells.»

Recently, however, ephrins and Eph receptors have also been found in extracellular vesicles / exosomes — small droplets of fat released by cells, used as transport vehicles, signal transmitters or for eliminating cell components.

«They are currently used to enhance certain weak signals in spectroscopy and for the development of compact optical components known as integrated optical / plasmonic interconnects,» observed Vohnsen.

One technical hurdle is to integrate all the components needed for a self - powered nanodevice to detect a change and transmit a signal to the web.

Cbl - b is an E3 ubiquitin ligase that targets multiple components of the TCR signal transduction pathway for degradation through the proteasome to facilitate termination of TCR signaling (19, 20).

Researchers have discovered that genetic mutations underlying two inherited eye disorders arise in different components of a single intracellular signaling pathway that is responsible for development...

While the threshold - like behavior of the de-greening circuit likely contributes to these differences, we can not rule out the need to balance our synthetic HK signal transduction components for optimal transmission, in a manner similar to that in bacteria [31].

In addition, because we developed PhoB - VP64 for plants by activating endogenous HKs with exogenous cytokinins [12], it is likely that our synthetic signal transduction system (receptor → HK → PhoB: VP64 → signal receptive promoter) has false input or cross-talk from plant HK components.

We evaluated the expected error in astrometry and photometry as a function of the signal to noise of companions, after spectral differential imaging (SDI) reduction for IRDIS and spectral deconvolution (SD) or principal component analysis (PCA) data reductions for IFS.

While homology - based approaches are likely to be reliable for well - conserved pathways such as the core signaling components of the innate immune network, it is difficult to confidently assign function to the numerous proteases, protease inhibitors, and similarly diverse gene families in the absence of direct functional information.

But this was only the beginning; we still had to find the tools for visualising TrkB and the phosphorylated components of its signalling cascade.

For example, the expression of BMP - Smad signaling pathway components is low during differentiation of mDA neurons from their VM neural precursors in vivo (E10 — E12), yet after this period, these subsequently increase in expression and play a functional role in mDA neuronal outgrowth (E1 — E18)[37].

We used a bioninformatics analysis to identify that miR - 181a targets components of the bone morphogenetic protein (BMP) signalling pathway, including the transcription factors Smad1 and Smad5, which we find are expressed by rat mDA neurons and are required for BMP - induced neurite growth.

The Center for Cell Circuitry addresses the enormous therapeutic potential of cellular circuits, which connect individual molecular components and allow cells to process signals and control decision - making.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) traSignaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) trasignaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) trasignaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) trasignaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Suite of biological assays (Autophagy, Apoptosis, Signalling cascades) for investigating interactions of lipid droplets and components with cells

Our contributions to this field have helped to change the way endocytosis is perceived, from being simply a mechanism for signal attenuation to being a vital component of the cell signalling machinery that provides spatial and temporal dimensions to signalling events (1).

These results indicate that the signaling pathways for the two types of IFN and double - stranded RNA share common components or that their function depends on common enzymes or transcription factors.

The dorsal pancreatic bud was enriched for components of Notch, Wnt, BMP, and FGF signaling, almost all genes known to cause pancreatic agenesis or hypoplasia, and over 30 unexplored transcription factors.

For example, electromechanical devices, e.g., micro actuators, microelectromechanical devices, or piezoelectronics, could have movable physical components that move up and down when stimulated by a mechanical force or an electrical or magnetic signal, thereby moving the overlying surface.

Leucine is both a component of muscle but also a potent signaling molecule for a protein called mTOR which, when activated, tells muscle cells to collect and store amino acids.

The component in buckwheat responsible for its blood glucose - lowering effects appears to be chiro - inositol, a compound that has been shown in other animal and human studies to play a significant role in glucose metabolism and cell signaling.

usually yes, component id for 16:9 tv's but it CAN be used by an console that outputs a 4:3 signal like the gamecube for example.

In choosing this year's «Better Balance,» for example, the editors signaled that something is awry in the existing balance between the «hard» elements of standards - based reform (namely the academic standards, assessments, and interventions that make up a state's accountability system) and such «soft» components as teacher training, instructional materials, and classroom environment.

The SID also controls other vehicle components, including but not limited to audible warnings for turn signals and the vehicle's horn.

====== OPTION PACKAGES: BURMESTER HIGH - END SURROUND SOUND SYSTEM: 16 individually driven loudspeakers including a 25 - cm 300 - watt active subwoofer with Class D digital amplifier, complex high - end components such as special ribbon tweeters (air motion transformers (AMT)-RRB-, preset sound sets and sound conditioner, WHEELS: 21 911 TURBO DESIGN: front / rear: 10J x 21RO50, 1 - piece alloy wheels, wheel centers and full - color Porsche crest, Wheel Arch Extensions, Tires: 21, PREMIUM PACKAGE PLUS: Front Seat Ventilation, seat squabs and backrests in the front featuring three - stage ventilation and separate controls for left and right, Porsche Dynamic Light System Plus (PDLS), Lane Change Assist (LCA), a visual signal from the exterior mirrors, Porsche Dynamic Light System Plus (PDLS Plus), Panoramic Roof System, 2 segments of tinted safety glass, electrically operated sunscreen covering entire glass and comfort closing facility, Reversing Camera with Front & Rear ParkAssist, a color camera image with dynamic guidelines on the audio system CDR Plus and the Porsche Communication Management (PCM) screen facilitates controlled and precise reverse parking and maneuvering, Electric Sunblinds for Rear Side Windows Horsepower calculations based on trim engine configuration.

A new dimension in sound The Premium Sound audio system with enhanced bass, created by sound specialists at BMW M, incorporates high - quality hi - fi components designed especially for use in automobiles and a newly developed BMW - exclusive signal processing technology.

Samsung normally provides components to other OEMs for their devices so this is nothing new, though it does signal that the company is satisfied enough with yields of the Exynos 7420 processor that it's providing them to Meizu aside from putting the same chip inside the Galaxy S6 models as well as the Galaxy Note 5.

Indeed, trading price action setups from horizontal levels is the «core» component of my trading theory and strategy, and if you were to take away only one thing from my website it would be that you can learn to trade the market effectively by simply drawing the core levels on your charts and waiting for obvious price action signals to form around them.

The binding of antibodies can render key components of a microbe necessary for invasion or even survival ineffective or in some cases signal other cells of the immune system called macrophages to consume and remove the microbe.

If you have a system with lots of noise, cancelling known components of that noise is a well tested method for bringing out signal.

Table 1: Trends in °C / decade of the signal components due to MEI, AOD and TSI in the regression of global temperature, for each of the five temperature records from 1979 to 2010.

I accept the attenuation of higher frequencies but the biggest component, the fundamental, which accounts for a large part of the total signal is totally AWOL.

«Using the identified climate signal as our spatiotemporal filter, normalized reconstructed components (RCs) were generated for all indices, each reflecting a multidecadal signal that centers on ~ 64 years.»