Sentences with phrase «signal event»

We also do culture of cells and tissues isolated from mice to manipulate signaling events in controlled, measurable ways.

We then interpret this as evidence that the two proteins of interest are physically interacting with each other — a molecular signaling event.

There are about 1,000 times as many background electromagnetic events as there are predicted signal events.

Instead it relies on identifying dark matter signal events by their time dependence.

In many immune cells, lethal toxin turns off signaling events through degradation of intermediate signaling components.

We will focus more specifically on the intracellular fragment of APP that could initiate signaling events.

Today, a team of researchers at Cold Spring Harbor Laboratory reports in the journal Genes & Development that they have arrived at «new insights into signaling events that underlie metastasis in ovarian cancer cells,» says Gaofeng Fan, Ph.D., postdoctoral investigator who conducted most of the experiments, in the laboratory of his mentor, CSHL Professor Nicholas K. Tonks.

Researchers at the Medical University of South Carolina (MUSC) have identified one mechanism that regulates signaling events leading to cell migration and metastasis.

For example, this method could be used to study cell signaling events between normal and malignant cells in order to better understand the molecular mechanisms by which surrounding normal cells alter tumor growth and response to treatment.

Overall, these studies will progress our understanding on how organismal aging is an integrated process resulting from signaling events in muscle and other tissues.

Write narratives in which they recount a well - elaborated event or short sequence of events, include details to describe actions, thoughts, and feelings, use temporal words to signal event order, and provide a sense of closure.

Unlike other positive selection - deficient mutant mice, Gasp − / − mice showed a defect only in positive selection among all of the TCR - induced signaling events.

Grondin has done substantial archival work to settle what the book's jacket calls «the facts of Gadamer's life»: upbringing, schooling, teachers, degrees, appointments, major publications, and other signal events (Gadamer's early illness, his two marriages, his arrest by East German police).

«Our findings suggest that signaling events required for neurodevelopment may also play major roles in neurodegeneration,» Van Damme says.

«This study demonstrates the significance of mammalian iRhoms in regulating an EGFR signaling event that promotes accelerated wound healing and triggers tumorigenesis,» Shultz says.

Discovered a series of signaling events beginning with the morphogen Sonic hedgehog (Shh) that are essential for guiding a population of late cardiac progenitor cells in the outflow tract of the heart.

Owing to the unique capability of flow cytometry to measure events at a single - cell level, «Phospho Flow» allows for the identification of rare signaling events during co-stimulation and manipulation of checkpoint inhibition.

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

Setton also identified a gene, called arrow, that when disrupted set off a cascade of cellular signaling events suggesting for the first time important relationships between segmentation and leg - development genes found across insects and arachnids.

We focus on signaling events initiated by a class of seven - transmembrane spanning receptors, the G - protein coupled receptor (GPCR) family.

Ideally, identification of mediators of the inflammatory response in AMD will yield novel therapeutic approaches to this common and often severe form of blindness, in the form of either blocking or inducing TLR2 signaling events.

His doctoral thesis revealed how isoprenylation of MIEN1 protein can regulate its translocation to the plasma membrane and activate signaling events leading to increased invasive phenotype (JBC, 2011; Mol Can, 2015).

Importantly, costameric proteins and associated signaling events are increased in humans in response to eccentric training, and are decreased in response to the mechanical unloading that occurs during bed rest (Li et al. 2013).

Briefly, a cascade of intracellular signaling events influenced by energy status, growth factors, and nutrient availability regulate muscle protein synthesis by modifying mRNA translation initiation and elongation (18, 30).

Isolated potential signal events from Monte Carlo data samples for a specific decay of vector - like B quarks using CERN's root software.

A team of researchers at Cold Spring Harbor Laboratory discovers new insights into signaling events that underlie metastasis in ovarian cancer cells...

Her interests centre on developing methods for quantitative proteomics, phosphoproteomics and methods for tracking changes in sub-cellular localization of the proteome in response to cell signalling events.

Adherence of H. pylori to gastric epithelial cells is critical for induction of inflammation and injury; therefore, the overarching theme for our research has been delineation of the molecular signaling events initiated by bacterial: epithelial cell contact that regulate phenotypes related to carcinogenesis.

Write narratives in which they recount two or more appropriately sequenced events, include some details regarding what happened, use temporal words to signal event order, and provide some sense of closure.

In any event, he is surely right that the collapse of the universities as repositories and transmitters of Murray's «consensus» was a signal event in the Sixties, whether one chooses Berkeley, Cornell, or Columbia as Ground Zero.

Before peering ahead to what may be coming, though, we look back at some of the signal events of the past term.

This optimisation will allow the team to increase the number of signal events, and reach the sensitivity required to show to what extent this process agrees with the Standard Model prediction.

They call this form of activation «non-ligand-dependent,» and in a complex series of biochemical and animal experiments, traced the pathway through which FER's binding to MET inside the cell sets off a cascade of cell - signaling events, all directly connected in prior research with cancer initiation, including RAC1 / PAK1 and SHP2 - ERK.

But, through mutations, cancers find ways to create new PTMs and signalling events, effectively manufacturing millions of different keys.

«That was a signal event for me,» Campbell says.

In addition to illustrating key transcription interactions and signaling events, the scientists gained insight into how epigenetic marks — traits that are inherited without changes to the DNA sequence — are «erased» at the beginning of germ cell development.

Elucidated a cascade of transcriptional and signaling events that control the early steps of cardiomyocyte differentiation in a chamber - specific manner.

Phosphoinositide kinases are regulated by upstream cell - signaling events.

We are currently investigating the details of the signaling cascades involved in these phenomena, as well as attempting to identify cytoplasmic binding partners for NG2 which may serve as effector molecules for activation of downstream signaling events.

Our contributions to this field have helped to change the way endocytosis is perceived, from being simply a mechanism for signal attenuation to being a vital component of the cell signalling machinery that provides spatial and temporal dimensions to signalling events (1).

This might be because adaptor molecules like RhoH and SLP76 can affect the signaling events downstream of calcium release from the ER, or might indicate the existence for a possible positive feedback pathway from calcium signaling to the upstream of adaptor molecules.

Engagement of the T cell receptor is responsible for initiating the signaling events that can activate, inactivate, or eliminate T cells, depending on the magnitude and duration of the signal.

Few are more aware of this isolationism than secondary school teachers, particularly those who teach history using standard texts that — not surprisingly — view the signal events of American history with a kind of national solipsism.

Newarkers can point to two signal events, both in 2010, that ushered in the era of major reform: Chris Christie's rise to governor and Facebook founder Mark Zuckerberg's $ 100 million donation to reform the Newark school system.

It shows how the signal events of the last half century affect the course of a life lived in New York City.

Produced by F+W Media's Digital Book World vertical, DBW is one of the signal events of the publishing - conference year.

The Guardian sees the Kindle Singles program as the signal event in this part of the revolution.