Sentences with phrase «signal pathways»

A novel computational analysis of the resulting datasets produced personalized diagrams of signaling pathways in the cancer cells of each patient, the details of which suggest potential targets for therapy.

By blocking a specific cell signaling pathway in lab animals, researchers reversed signs of chronic immune activation, thereby boosting T - cell recovery and viral suppression.

These rhythms can also affect signaling pathways involved in medication toxicity.

These physical effects lead to cell signaling pathways for enhanced cell survival.

In order to investigate the mechanisms leading to improved insulin sensitivity with exercise training, it is necessary to analyze some of the components of the insulin signaling pathway in skeletal muscle.

We will perform experiments that will investigate the role of a newly identified signaling pathway in the aging fly intestine.

A molecular signaling pathway determines the worm's life - span.

A fourth study finds that a generalized seizure leads to diminished short and long - term memory by interfering with key signaling pathways in the brain.

In addition, more than 600 genes are either receptors or associate closely with receptors, providing a thorough analysis of important signaling pathways.

Her research focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.

The research results give novel insights into how signaling pathways are regulated in time and space in order to facilitate migration of cells only in one direction.

The effect is related to insulin signals, the same signaling pathways that have been modified to extend the lifespan of fruit flies by 50 percent.

To prevent this from happening patients are treated with a second compound that stops this cell signaling pathway from being unintentionally activated.

Today, we learned that probiotics talk to our bodies using various signaling pathways and that strains vary in their ability to manipulate these pathways to promote health.

The switch, they say, is composed of regulatory proteins that control an immune signaling pathway in cells.

Work in my lab investigates signaling pathways that regulate cell - cell interactions during development of pancreatic cancer.

These studies revealed the important roles of several signaling pathways, including ones not previously known to play a role in taste.

These proteins interact to form complex signaling pathways that can have wide - reaching effects.

These small molecules exhibit fascinating chemical diversity and regulate lifespan, reproduction, behavior and many other traits, often through signaling pathways that are shared throughout the animal kingdom.

I was desperately interested in trying to understand how we could manipulate signaling pathways to improve the treatment of injuries.

One pathway — the insulin - like signaling pathway — was much less active in the left knee joint of the mice.

The researchers found that each nutrition molecule made use of different receptors and common signaling pathways to accomplish this.

Previous research has shown a link between the brain's stress signaling pathways and AD.

A combined experimental and computational approach, to better understand signaling pathways that lead to genetic mutations, is at the core of this research.

His research focuses on the cancer biology, drug resistance, and signaling pathway networks of human diseases as well as on ways to model these disorders.

In different parts of a tumor there are differing signaling pathways and receptors and various proteins, which are key for signaling in cells.

Finally, the team conducted extensive cell experiments to confirm the computer - generated signaling pathway model.

A simple signaling pathway tells plants whether to grow tall in search of sunlight (far right) or to develop leaves (left).

The studies presented here demonstrate that the capacity for promoting muscle growth by targeting this general signaling pathway is far greater than previously appreciated.

As a result, they believe it may be necessary to simultaneously target multiple development signaling pathways to prevent cancer from becoming resistant to therapy.

A fashionable contrary view has arisen: antioxidants not only don't help, they can do harm by interfering with oxidative signaling pathways.

Through gene profiling, they were able to discern that absence of gut bacteria altered genes and signaling pathways involved in learning, memory, and motor control.

The research team also found that expression of genes that control glucose metabolism and insulin signaling pathways were higher in rats that consumed sufficient amounts of vitamin A.

In addition, we have identified signaling pathways that are activated as part of the integrated stress response in response to soluble amyloid - beta and in AD model mice.

Her group aims to unveil the molecular signaling pathways that are relevant for cardiac disease.

This includes chronic inflammation, DNA damage and disruption of cell signaling pathways.

A fundamental question is how signaling pathways are regulated in time and space to facilitate directional migration of cells.

These compounds can then be used as tools to further study the target proteins function and signaling pathways in cells.

These observations suggest that in addition to LOH, promoter methylation, and the APC mutations, miRNAs that target APC may regulate the aberrant activation of the canonical WNT signaling pathway for the initiation of human breast cancers, the enhancement of niche independence, and the aberrant proliferation of the human BCSCs.

Researchers in Uppsala and Umeå have found a new signaling pathway activated by TGFβ that makes tumor cells more aggressive.

Specifically, they piece together a molecular signaling pathway by which a protein called vascular endothelial growth factor (Vegf) directs the activation of Delta - like 4 (Dll4), which is critical to artery formation.

[8] Genovese T, Esposito E, Mazzon E, Di Paola R, Meli R, Bramanti P, Piomelli D, Calignano A, Cuzzocrea S. Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury.

Thus, dysregulation in the mTOR signalling pathways plays a role in the development of a number of diseases.

Surprisingly, we found that high levels of potassium, which was released by dying cells in tumours, had very little effect on calcium but blocked activation of a cellular signalling pathway called the PI3K pathway when T cells encountered tumour antigens».

Now, Dr. Katharina Walentin and Professor Kai Schmidt - Ott of the Max Delbrück Center for Molecular Medicine (MDC) Berlin - Buch have discovered a new molecular signaling pathway which regulates the development of the placenta.

GSK3 (Glycogen Synthase Kinase - 3) is a signaling mediator involved in a variety of different signaling pathways including WNT, growth factors, insulin, and Hedgehog pathways.

The mutation impacts an important signaling pathway known as Wnt, that contributes to the function of many cell types.»

Here, Dr. Tam presents data characterizing the intracellular signaling pathway associated with the RANK — RANKL axis, as well as the effect in dendritic cells, antigen - specific T cells, cytokines, and chemokine profiles after in vivo treatment with blocking PD - L1 and T cell - depleting antibodies in a melanoma cancer model.