Sentences with phrase «signal sequence of»

N - terminal signal sequence of gp replaced by that of tissue plasminogen activator (tpa)-- cleaved from

Signal sequence of env replaced by tpa to direct secreation of rgp105 into culture medium

Not exact matches

After all, in a calculator, the pressing of «2» followed by «+» followed by «3» followed by «=» leads to a sequence of purely material (electronic) events that produce a final electronic signal to display the number 5.

«Such losses are particularly critical in the auditory system, because they reduce the temporal precision of signal transmission — and the quality of our perception of the acoustic environment is primarily dependent on rates of action potential generation and precise neural computation of their temporal sequences.»

But to coax them down a specific path in the lab requires recreating the precise sequence and timing of environmental cues in the womb — the signals from proteins and hormones that tell cells what kind of tissue to become.

While the latter has a reputation for being hard to isolate, she explains that even degraded RNA generally contains enough intact sequence to analyze — provided investigators can detect the scarce tumor signals against the immense background of other RNA molecules in a sample.

A second, well - understood form of epigenetic signaling, called DNA methylation, involves the addition of a methyl group — a carbon atom plus three hydrogen atoms — to particular bases in the DNA sequence.

By studying and comparing the structure of unbound SRP with a signal - sequence bound SRP, a detailed picture of the impact of this binding is now available.

In order for newly - produced secretory or membrane proteins to find their final destination, the proteins have signal - sequences connected to themselves as a form of address tag.

Detail of a crystal structure of unbound (right) and signal - sequence bound SRP forms (left, signal sequence depicted in red).

Researchers at Umeå University show in a new, detailed structural study, published in the journal Nature Communications, how the binding of the signal - sequence triggers a number of structural changes within the SRP particle.

The structure of the SRP signal - sequence complex is determined using x-ray crystallographic methods.

The researchers investigated how Suv39h1 employs a positive feedback loop to chemically tag thousands of adjacent histones, thus signaling the cell to stow away these underlying, unnecessary DNA sequences.

But this part of the project became «almost insignificant» when he discovered a sequence - specific silencing signal spreading through a plant, Voinnet says.

The link protocol is equipped with self - developed smart analog circuits that can rapidly align the receiver's clock with the arrival of the incoming data, and detects the optical signal sequences to rapidly turn the link system on and off.

Previous studies identified three sub-events at intervals of 20 seconds in the seismic signals recorded during the 1980 Irpinia earthquake sequence, whose shared ground motion caused more than 3000 deaths and significant damage to structures.

The lizard's signalling was reconstructed by digitising the position of multiple body parts through the sequence, subsequently combining the data from the two camera views to reconstruct the signalling motion in 3D, Ms Bian said.

The scientists then subtracted the EEG signals taken in response to a face sequence from those of a pattern - only sequence to extract the unique signature associated with the face stimulus and tracked how this electric signal evolved over time.

Still unclear is how the methuselah gene mutation makes flies more stress - resistant, but the amino acid sequence of the protein it makes may be part of a signaling pathway that controls how well cells resist or repair these stresses.

«The computational approach allows us to model, right down to the atomic level, how small changes in protein sequence can have a major impact on signaling,» said MacDermaid, assistant professor of research at Temple's Institute for Computational Molecular Science.

Three images, left to right, of the same thundercloud depict a less - than -10-milliseconds-long sequence of events: (left) formation within the cloud of a small channel, or «leader,» of electrical conductivity (yellow line) with weak emission of radio signals (ripples), to (middle) a burst of both dark lightning (pink) and radio waves (larger ripples), to (right) a discharge of bright lightning and more radio waves.

For Virginia Postrel, writing in The Atlantic back in 2007, it was dramas like CSI and Numb3rs that were making braininess sexy and imparting a «geeky glamour» to the airwaves — and that was before the rise - to - total - dominance of House, a prime - time juggernaut whose climax each week involves a man having a scientific epiphany illustrated by an animated sequence of a corpuscle misinterpreting a hormonal signal from a gland.

The final component in this long series of signal sequences is the Yorkie effector protein that is the decisive factor at the end of the Hippo signaling pathway and determines the start of reactivation, growth, and division in the stem cells.

When an external signal is detected by the cell, the other plasmid is also activated, leading to insertion of its sequences instead.

The result is a mixture of background sequences that record time and signal sequences that change depending on the cell's environment.

In the absence of an external signal, only the recording plasmid is active, and the cell adds copies of a spacer sequence to the CRISPR locus in its genome.

As a result, they observed an interesting pattern — that the same components could both turn on and off some of the steps in the sequence — a phenomenon called paradoxical signaling.

Top: Typical image sequences (every 33 milliseconds) of a raft domain undergoing signaling (green) and a sphingomyelin analog (red).

«It's clear we lost the signal from the lander, but we don't know where it happened in the sequence of events,» Ferri says.

MESSAGE CORD A bundle of animal hairs signals the beginning of a sequence of twisted and knotted cords on an 18th century khipu from a Central Andean village.

Three - letter genetic sequences are known as codons, and they can either code for an amino acid — the building blocks of proteins — or act as stop signals.

Small organic sensor molecules were prepared that bind and signal the presence of unlabeled tripeptides in a sequence - selective manner.

The Viterbi algorithm can search for the most probable sequence of two - speaker states to explain the total audio signal.

By sequencing the genes of a population of cells that all contain the program, researchers can determine the magnitude and duration of the signal: The more cells have the genetic mutation, the stronger or longer the signal was.

Like many biological processes, it involves an entire sequence of molecular signals that result in the formation of new cells and tissue.

That allows for more interactions between the pore and a DNA strand, which can degrade the electrical signals of interest for sequencing.

To the other jug she added two enzymes that targeted the sequence that signaled the presence of a knight in the two threatened positions.

But in front of it was a termination sequence, flanked by two snippets that signaled the DNA recombinase.

Whatever their limitations, the two reports signal the dawn of a new era in genome sequencing and detecting changes in individual genomes.

The sequence, called an ITAM (immunoreceptor tyrosine - based activation motif), encodes a piece of protein that can by itself signal immune system cells to multiply and go to work.

Signal molecules and proteins that have this sequence trigger a reaction of the cell.

Gene expression is regulated by epigenetics — patterns of chemical signals that are «above» the gene sequence.

He plans to figure out how and if the sequence of developmental signals directs embryonic stem cells to transform into more specialized cell types.

Mostafa Ronaghi, Ph.D., Stanford Genome Technology Center, Palo Alto, Calif. $ 1.8 million (3 years) «Pyrosequencing Array for DNA Sequencing» The principal investigator of this team is an inventor of pyrosequencing, which uses unmodified nucleotides and polymerases to synthesize DNA and a firefly enzyme to generate a chemiluminescent signal.

Shannon entropy analysis of the NS5 polymerase mature protein revealed that a G374E mutation, in a region that contributes to interferon resistance in other flaviviruses by interfering with JAK - STAT signaling was present in both the Asian and American sequences from the 2007 - 2008 Venezuelan outbreak, but was absent in the sequences from the 2001 Venezuelan outbreak.

Many of these sequences are non-coding, such as regulatory signals, structural sites and RNA genes.

The group of researchers will work on further developing a highly integrated and parallel format with improved equipment for detection of the chemiluminescent signals resulting in a portable and inexpensive device for low - cost genome sequencing.

Our discovery that this conservation also extends to the level of HK transmembrane signaling allowed us to design a test system, whereby transmembrane fusions can be rapidly developed and tested in bacteria and then, with the addition of proper targeting sequences, function in plants.

Our AST - VAC immunotherapy programs employ three common elements of dendritic cells, telomerase antigen, and the LAMP signal sequence to stimulate robust and specific immune responses to cancer cells (Figure 1).

To evaluate these options, the manuscript contrasts sequence information from Egyptian and Ethiopian genomes and with a panel of Eurasians, showing that Egyptians are the modern Africa population harboring the strongest signal of that past migration and, hence, favoring a northern exit as the most likely route out of Africa.