Sentences with phrase «signal system including»

Not exact matches

The $ 136,000 car was tricked out with just about every technological addition on the market today: a rear - view camera (including night vision), electric rear and side shades, satellite radio, active blind spot detection, a steering wheel that rumbles if you change lanes without signalling, a touch - knob - controlled heads - up - display with GPS and a high - end Bang & Olufson sound system complete with dashboard - mounted tweeter.

This includes learning the power of regulating and leveraging emotions; understanding that reason and intuition are the twin engines of decision making; listening to your physical signaling system to increase energy and insight; and staying connected to the power of your purpose and passion.

Also, the system is great at helping other platforms; including Banc de Binary provide the best signals to their clients.

This signal activates your brain's reward system — which includes «dopamine hotspots» — and then your brain's reward system subconsciously tells you that you should eat another Oreo to continue feeling those warm, happy vibes of ecstasy.

Arsene Wenger took a bit longer to realise the strengths of the system, and it was only after a disastrous run of results, including a 3 - 1 embarrassment at Stamford Bridge, that Wenger finally lined up with a 3 -4-3 formation for the first time in 20 years, and that also signalled a massive upturn in form.

Although there are no current game matches for any of our previously discussed betting systems, there have been two very profitable bet signals triggered on this game including a reverse line movement alert and steam move at CRIS — one of the top books that we track.

In this way, the six world powers, including the U.S., will remain in full control of handling «gamer» nations such as Iran, subtly swaying, stopping and signaling at the right moments to ensure the Islamic Republic does not spoil the international system.

The multi-point strategy includes increased testing of tracks and signals, placing emergency personnel around the system to get to distressed passengers more quickly and putting additional cars into service faster.

To improve mobility and traffic patterns, the project will include: · Improved access to Woodbury Common Premium Outlets · Replacing the Route 32 bridge over Route 17, which will include standard Interstate height clearance over Route 17 · Reconstruction and expansion of Park and Ride facilities which will include a bus stop and solar - powered bus station to promote public transit · Reconfiguring the Route 17, Exit 131 eastbound ramp leading to the Thruway · A new interconnected and adaptive traffic signal system along Route 32 to minimize delays and enhance access to local businesses and schools · Intelligent Transportation Systems to adapt to changing traffic conditions and optimize signal responses

Lhota's plan includes an $ 836 million short - term renewal project: signal and track maintenance, car reliability, system safety and cleanliness and customer communications.

However, in a letter to MTA interim Executive Director Veronique Hakim, Republican state Sens. Kemp Hannon (R - Garden City) and Elaine Phillips (R - Manhasset) said any changes to the capital budget should include investments throughout the entire LIRR system, including a move «toward an advanced and modernized communications and signal infrastructure to increase operational capacity and provide safe and reliable service.»

Senate Majority Leader John Flanagan (R - East Northport) announced the action while noting that the Metropolitan Transportation Authority, which runs the LIRR, had agreed to upgrades, including renovated station stops and new parking garages in impacted communities, along with an updated signal system for Penn Station.

State officials also revealed additional sites that will be investigated further as possible sources of contamination, including the Hoosick Falls Landfill, the former Oak - Mitsui on First Street and Allied - Signal Laminate Systems on Mechanic Street.

The project will also include elevated grade crossings, renovated stations and an updated signal system at Penn Station.

Mr. Cuomo announced the emergency plan after months of constant disruptions and coverage by The New York Times about the decrepit state of the subway, including its fragile signal system and increasingly malfunctioning trains, and the escalating financial cost to riders.

The researchers collected the brain activity — five additional sensors were placed on the volunteers» faces to allow researchers to screen for the impact of random movement, including eye blinks — and then mapped the signals back to the brain to determine how specific parts of the brain are involved in discrete tasks associated with walking, said Trieu Phat Luu, co-first author and a post-doctoral researcher in the Noninvasive Brain - Machine Interface System Laboratory at UH.

Her system included pulse - generating proteins that could send and receive signals.

Angrites are igneous rocks, many of which are thought to have erupted onto the surface of asteroids very early in the solar system's history and then quickly cooled, freezing their original properties — including their composition and paleomagnetic signals — in place.

Downstream of the signaling system, Runx2 overexpression led to overexpression of bone - related genes, including genes expressed by osteoblasts, osteoclasts and osteocytes.

Saatchi, which is owned by France's Publicis Groupe, SA, chose LifeStraw over a field of competitors that included a reusable controller to improve the distribution of IV fluids, a collapsible wheel that can be folded down for easier storage when not in use on bicycles or wheelchairs, an energy - efficient laptop designed for children in developing countries, a 3 - D display that uses special optics and software to project a hologramlike image of patient anatomy for cancer treatment, an inkjet printing system for fabricating tissue scaffolds on which cells can be grown, a visual prosthesis for bypassing a diseased or damaged eye and sending signals directly to the brain, books with embedded sound tracks to help educate illiterate adults on health issues, a phone that provides telecommunications coverage to poor rural populations in developing countries, and a brain - computer interface designed to help paralyzed people communicate via neural signals.

In this rewriting of the textbooks, a tumor is not just a clump of aberrant cells; it also includes a support system, a tumor microenvironment, which encompasses a multitude of varying immune cell types and crisscrossing chemical signals, along with a network of blood vessels.

The basic configuration of the researchers» system includes a neural network trained to identify subvocalized words from neuromuscular signals, but it can be customized to a particular user through a process that retrains just the last two layers.

The system, which has been installed in Swedish banks and hospitals, includes a device that encrypts the fax signal so that it is only accepted by SealFax machines.

This network includes a set of serotonin - sensitive neurons known as URX neurons, which have access to the worm circulatory system and apparently release a still - to - be-identified signaling molecule.

Reinforcement of addictive substance use and stress signaling involves common neural systems, including the brain reward center.

The arrays were connected by a cable to a system of computers that processed the signals, decoded the intent of the subject, and controlled output devices that included a computer cursor and a robotic arm developed by collaborators at Johns Hopkins University.

The system includes sensors that capture acoustic signals and analyze the audio data for mood and stress.»

Consistent with other studies, they found that as early as 13 weeks of development, the fetus was producing a range of immune system cells, including dendritic cells, which recognize invaders and signal other immune cells to attack.

Others have previously speculated that the biological basis of psychiatric disorders such as PTSD includes a shift in the balance between different signalling systems in the brain but none has yet proved it.

Depression is associated with a multitude of pathological processes, including inflammation of the peripheral immune system, a set of biological structures and processes in the lymph nodes and other tissues that protect against disease and abnormalities involving synapses, the structures that permit neurons to pass an electrical or chemical signal to other neurons.

Future work includes scaling down the signal processing module and capacitance measurement system to be co-mounted on skin with the sensor.

UNISI provides expertise in the measurement of cell signalling proteins, such as cytokines, chemokines and inflammatory biomarkers in multiple samples (including serum, plasma and tissue culture supernatants), using a multiplex suspension array system or a flow cytometric bead assay.

In the course of this work, he has pioneered several new approaches in the fruit fly that have had important implications for mammalian neurobiology, including: the demonstration that the fruit fly has a sleep - like behavior similar to that of mammals, studies of physiological and behavioral consequences of mutations in a neurotransmitter system affecting one of the brain's principal chemical signals, studies making highly localized genetic alterations in the nervous system to alter behavior, and molecular identification of genes causing naturally occurring variation in behavior.

The recent development of cell permeant NAADP and a potent NAADP antagonist in our laboratory has greatly facilitated the ability to investigate NAADP signalling in all systems: including the uterus.

We invite original innovative research on the rational engineering of plant systems at all levels, including proteins, protein complexes, sensors, metabolic and signalling pathways, microcompartments such as carboxysomes, subcellular compartments, cell types or tissues, as well as the engineering of novel plant hybrid species and the interactions of plants with viruses, bacteria, and other organisms.

Besides lipotoxicity (see section V.N) many other molecular mechanisms are involved, including mitochondrial dysfunction, oxidative stress, intramyocardial inflammation, involvement of the reninangiotensin system, altered insulin signaling or female - specific cardiac glycogen handling as a response to metabolic stress (308), and sex - hormone related myocardial calcium handling (309).

The complete synthetic signaling circuit was obtained by co-transforming the above - described plasmid containing ssTNT.R3 and Fls - Trg - PhoR with a previously described plasmid containing the PlantPho system [12] which includes the signal PhoB - VP64 under control of an FMV promoter and a PlantPho:: GUS - TNOS reporter.

Others were unanticipated, including significant differences in expression levels among genes involved in fundamental cellular processes such as ribosomal biogenesis, transfer RNA processing, and Notch - signaling — part of a complex system of communication that governs basic cellular activities and coordinates cell actions.

Reproductive selection and sexual competition are systems that undergo adaptive evolution in many organisms, including throughout primate evolution, and signals of selection were found in all three populations, according to Pritchard.

His research interests include the effects of surface geology on seismic motion, strong - motion data analysis, source parameters, application of signal processing with focus on borehole data, early warning systems and multihazard and multirisk assessment.

Second, he used this method to catalog the most important motifs in biological systems, including the now ubiquitous feed forward loop (FFL), which he showed provides a core set of specific signal processing functions in all cells.

Fryer's computational astrophysics work involving the largest explosions in the universe has impacted some of the most important open questions in astrophysics, including the origin of the elements, the nature and evolution of the first stars, the gravitational wave signals from compact binary systems, and the mechanism responsible for gamma ray bursts.

He will now investigate a set of molecules called TLR agonists that act through receptors on the surfaces of innate immune cells to set off a chain reaction of molecular signaling and activation within the immune system, which includes activation of latently infected CD4 cells.

In the brain, cells are among the units, migratory pathways are the highways or roads, and various electrical or chemical signals, including dopamine, are the communication systems.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) traSignaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) trasignaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) trasignaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) trasignaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

«Myeloid cells including macrophages have receptors for stress signaling molecules, which allows them to respond to cues from the sympathetic nervous system,» explains Hanna.

UNISI will provide expertise in the measurement of cell signalling proteins, such as cytokines, chemokines and inflammatory biomarkers in multiple samples (including serum, plasma and tissue culture supernatants), using a multiplex suspension array system or a Cytometric bead assay.

Practical applications include proton exchange membranes, proton - based signaling in biological systems and the emerging field of proton bioelectronics (protonics).

In addition, the physiological adjustments to chemosensory anxiety signals include attentional control systems (dorsomedial prefrontal cortex, thalamus) and a supramodal unit, timing the different emotional processing systems (vermis, cerebellum).

Interaction between the human host and its's microbiome is mediated via several axes of communication including the immune system, signalling and direct metabolic cross-talk that physiologically connect the gut with the brain, muscle and liver.