Sentences with phrase «signal transduction»

It is a rare autoimmune disease that results in the body producing antibodies against the NMDA receptor, a protein that plays an important role in signal transduction in the brain.

We describe assembly and function of a complete synthetic signal transduction pathway in plants that links input from computationally re-designed PBPs to a visual response.

Roberto Villasenor (Zerial, MPG)-- «Regulation of signal transduction by endosomal EGFR distribution» (2012)

Diagram of the complete synthetic signal transduction system in transgenic plants, using TNT as the ligand, signaling through the bacterial chimeric histidine kinase, and adapted response regulator, then activating a transcriptional response.

At the cellular level, it signals through a cell surface receptor kinase - mediated signal transduction pathway instead of through the nuclear receptor family of transcription factors.

An important one of these is its role as a natural inhibitor of signal transduction by hedgehog (a hormone involved in morphogenesis).

Citation: Antunes MS, Morey KJ, Smith JJ, Albrecht KD, Bowen TA, Zdunek JK, et al. (2011) Programmable Ligand Detection System in Plants through a Synthetic Signal Transduction Pathway.

We have identified three classes of signal transduction mechanisms that may be mediated or modulated by NG2.

This work revealed new roles for XBP - 1 in regulating signal transduction through the B cell receptor; in regulating the expression of important transcription factors in B cells; in maintaining proper lipid synthesis and protein glycosylation in B cells; and in colonization of stimulated B cells into the bone marrow for sustention of antibody production.

Drugs like Gleevec ®, known as signal transduction inhibitors, work by «turning off» specific proteins in cancer cells that cause cancer cells to grow and multiply.

In 1995, I began graduate studies on signal transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 2000.

Among these was the protein VGLUT1, which is essential for signal transduction in specific nerve cells.

One possibility is that previously - described receptor instability in vitro [5] precludes typical biochemical analysis, whereas in bacteria or plants, the receptor is continuously produced, and hence activates signal transduction.

(A) GUS activity with and without 10 µm of the TNT ligand in paired leaves from transgenic plants serving as negative controls and transgenic plants containing the complete signal transduction system.

My postdoctoral work involved signal transduction pathways that regulate chemotaxis.

While the threshold - like behavior of the de-greening circuit likely contributes to these differences, we can not rule out the need to balance our synthetic HK signal transduction components for optimal transmission, in a manner similar to that in bacteria [31].

Berberine improves insulin signal transduction by stimulating glucose intake via the activation of the AMP - activated protein kinase pathway.

Science Signaling offers original review articles, protocols and teaching resources for the growing field of cellular signal transduction.

In addition to authoritative insights and collections of reviews, features, and News Focus articles in Science, Science's Signal Transduction Knowledge Environment and the Science of Aging Knowledge Environment will offer special content on drug discovery.

Thus, the focus of research in the Giovannoni lab is molecular and genetic analysis of fruit ripening and related signal transduction systems, using tomato as the model system.

Moffat and colleagues were the first to conduct time - resolved crystallography and developed photoactive yellow protein as a paradigm for light - dependent signal transduction in biology.

The p38 MAP kinase signal transduction pathway is an important regulator of proinflammatory cytokine production and inflammation.

Lowering caveolin - 1 expression in human vascular endothelial cells inhibits signal transduction in response to shear stress.

We discovered several Eph receptors and ephrins, and research in our laboratory is dedicated to the characterization of Eph receptor signal transduction mechanisms and biological functions using biochemical, mass spectrometry, molecular biology and cell biology approaches in conjunction with animal models.

Computational biology; use of control and information theory to study signal transduction pathways.

Plant HK components are involved in hormonal and possibly light - mediated signal transduction processes, hence it is difficult to eliminate their input in our system.

I studied the process called signal transduction - transmission of the activating mechanical signal from outside the cell, across the cellular membrane, to FAK inside the cell, leading to the activation of the kinase.

Anticancer activities of several anthelminthics attracted considerable interest, especially their capacity to target signal transduction pathways of CSCs / TICs of several tumor types.

We previously showed that the bacterial response regulator PhoB [14], [15] can be adapted to function in a partial synthetic eukaryotic signal transduction system [12].

While it is true that amino acids were long considered simply substrates for protein synthesis, they have more recently shown to also act as modulators of intracellular signal transduction pathways that are typically associated with growth - promoting hormones such as insulin and IGF - 1.

Heterotrimeric guanine nucleotide — binding protein (G protein)-- coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane.

It is all clinical pharmacology, which is really applied signal transduction.

He uses Arabidopsis to look at light signal transduction.

Interestingly, hNSCs highly expressed receptors involved in STAT signal transduction such as LIFR and IL6ST.

Countering the prevailing theory that cellular hydrogen peroxide signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive oxygen species (ROS) in fact triggers a distinct signal transduction cascade under control of the mitochondrial respiratory chain — the Syk pathway — that regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.

We do a lot of detailed signal transduction pathway mapping, Kinase assays and binding assays.

It is expected that the molecular mechanisms underlying the inhibition of interferon signal transduction by C proteins would then be fully identified.

She searched for other systems in which signal transduction is important and ended up studying opiate response in the brain.

The isoforms beta ARK - 2 and beta - arrestin - 2 are highly enriched in and localized to the dendritic knobs and cilia of the olfactory receptor neurons where the initial events of olfactory signal transduction occur.

His main research experience is systems pharmacology, systems biology, applied tissue engineering, cell biology and signal transduction networks.

Bacterial signal transduction systems are capable of transmitting information from the exterior to a response using as few as two proteins whereas eukaryotic systems typically use multiple components.