Sentences with phrase «signal transduction by»

Berberine improves insulin signal transduction by stimulating glucose intake via the activation of the AMP - activated protein kinase pathway.

Simplet / Fam53b is required for Wnt signal transduction by regulating β - catenin nuclear localization.

Nearly all his independent research relates to understanding light perception and signal transduction by the phytochrome superfamily of light absorbing molecules in plants and, more recently, in microbes.

Roberto Villasenor (Zerial, MPG)-- «Regulation of signal transduction by endosomal EGFR distribution» (2012)

Modulation of MHC Class II Signal Transduction by CD19.

ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2).

In 1995, I began graduate studies on signal transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 2000.

It is expected that the molecular mechanisms underlying the inhibition of interferon signal transduction by C proteins would then be fully identified.

Not exact matches

SU101 targets the signal transduction activated by a messenger called platelet - derived growth factor, which controls the genes involved in tissue formation and wound healing.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

Growth of osteosarcoma cells was inhibited by this drug by targeting of multiple signal transduction pathways [41].

His academic research focused on gene regulation and signal transduction mediated by ion channels and G proteins.

We then show that an adapted HK functions in plants by linking it to a transcriptional response through signal - dependent nuclear translocation of a bacterial response regulator [12], to produce a synthetic signal transduction system.

In addition, because we developed PhoB - VP64 for plants by activating endogenous HKs with exogenous cytokinins [12], it is likely that our synthetic signal transduction system (receptor → HK → PhoB: VP64 → signal receptive promoter) has false input or cross-talk from plant HK components.

Approaches successful in other systems, such as modeling signal transduction and synthetic biology methodologies [32] could improve future generations of detector plants by enhancing signal transmission and providing means to deal with biological «noise».

Homer 1, an actin binding protein that is induced by BDNF [72], belongs to a family of scaffolding proteins that localize at the postsynaptic density (PSD)[73, 74] and is believed to play a critical role in signal transduction, synaptogenesis and receptor trafficking at synapses [75].

Drugs like Gleevec ®, known as signal transduction inhibitors, work by «turning off» specific proteins in cancer cells that cause cancer cells to grow and multiply.

We have identified three classes of signal transduction mechanisms that may be mediated or modulated by NG2.

Symposia III: Mechanisms of Baro and Chemoreceptor Sensory Transduction: A Link to Sympatho - excitation in Disease Researchers will discuss how sensory neuronal signals are powerful regulators of the hypertensive state and the role of gaseous messengers in oxygen Sensing by the carotid body.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a signal transduction pathway that appears to involve an amino acid sensing GPR [37].

Finally, it must be acknowledged that our data are potentially limited by providing only a single «snapshot» during recovery and the possibility exists that our muscle biopsy time - points failed to coincide with peak phosphorylation responses of signal transduction.