Countering the prevailing theory that cellular hydrogen peroxide signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive oxygen species (ROS) in fact triggers a distinct
signal transduction cascade under control of the mitochondrial respiratory chain — the Syk pathway — that regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.
My research investigates the role of a particular protein we initially thought was just a «dead» enzyme as a regulator in
signal transduction cascades (cellular communication).
Not exact matches
By functionally linking the
signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic
signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.
TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced
signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated
signal transduction, and cell lines that provide insight into the intracellular
signalling cascades of innate immune receptors.
Inhibition of
signaling pathways, especially of the Wnt / β - catenin and hedgehog
transduction cascades are newly described modalities involved in antitumor activity of the anthelminthics.
BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced
signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated
signal transduction, and cell lines that provide insight into the intracellular
signalling cascades of innate immune receptors.