Sentences with phrase «signal transduction in»

for article Activation of α2A - adrenergic signal transduction in chondrocytes promotes degenerative remodelling of temporomandibular joint.

Programs with research emphasis on signal transduction in development and oncogenesis, cell adhesion molecules in development and oncogenesis, muscologskeletal atrophy and countermeasures, ovarian follicle development, neural regeneration, implantable therapeutic or diagnostic devices and application of computers in veterinary education.

The study, Fish oil ameliorates trimethylamine N - oxide - exacerbated glucose intolerance in high - fat diet - fed mice, found that in mice, dietary FO ameliorated TMAO - induced impaired glucose tolerance, insulin signal transduction in peripheral tissue, and adipose tissue inflammation in HFD - fed mice.

Plasma adiponectin is positively associated with enhanced insulin signal transduction in skeletal muscle [38].

Fatty acids differentially influence phosphatidylinositol 3 - kinase signal transduction in endothelial cells: impact on adhesion and apoptosis.

Microplate readers can be used to detect GPCR signal transduction in living cells.

CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis.

While our analysis does not provide any details about how the computationally re-designed receptor binds the TNT ligand in planta, we consistently see reproducible signal transduction in our in vivo systems (bacterial and plant).

Signaling pathways were inhibited in osteosarcoma and, especially, Wnt / β - catenin signal transduction in ovarian cancer cells and via GSK3 and STAT3 in CSCs and colon cancer [41, 47, 50, 52, 53].

On the one hand, we developed light - switchable compounds as tools for interrogating the dynamics of signal transduction in cells.

Moffat and colleagues were the first to conduct time - resolved crystallography and developed photoactive yellow protein as a paradigm for light - dependent signal transduction in biology.

It is a rare autoimmune disease that results in the body producing antibodies against the NMDA receptor, a protein that plays an important role in signal transduction in the brain.

Mutations of the gene Lps selectively impede lipopolysaccharide (LPS) signal transduction in C3H / HeJ and C57BL / 10ScCr mice, rendering them resistant to endotoxin yet highly susceptible to Gram - negative infection.

«The Cancer Genome Atlas is a really rich and growing database of publicly available data created to help us understand cancer,» said Horvath, who is a program co-leader of the Signal Transduction in Cancer program at the Lurie Cancer Center.

The H Foundation and a Signal Transduction in Cancer Training Program of the National Cancer Institute supported the research.

Among these was the protein VGLUT1, which is essential for signal transduction in specific nerve cells.

Not exact matches

Q: What were the challenges you encountered in going from materials science to trauma surgery and signal transduction?

In addition, he said, «The broader questions in gene regulation and signal transduction are also fundamental to immunity.&raquIn addition, he said, «The broader questions in gene regulation and signal transduction are also fundamental to immunity.&raquin gene regulation and signal transduction are also fundamental to immunity.»

In addition to authoritative insights and collections of reviews, features, and News Focus articles in Science, Science's Signal Transduction Knowledge Environment and the Science of Aging Knowledge Environment will offer special content on drug discoverIn addition to authoritative insights and collections of reviews, features, and News Focus articles in Science, Science's Signal Transduction Knowledge Environment and the Science of Aging Knowledge Environment will offer special content on drug discoverin Science, Science's Signal Transduction Knowledge Environment and the Science of Aging Knowledge Environment will offer special content on drug discovery.

Noticing that both grants and jobs in that field were few, she identified her most readily transferrable skill: her insight into cellular signal transduction.

SU101 targets the signal transduction activated by a messenger called platelet - derived growth factor, which controls the genes involved in tissue formation and wound healing.

Peter Parker of the Imperial Cancer Research Fund in London says he is delighted that a drug targeting signal transduction is now in trials.

The scientists would like to investigate how signal transduction is achieved in grasses whose vascular bundles are structured differently in comparison to Arabidopsis which belongs to the Brassicaceae family.

In addition to the increased collaboration, the intellectual critical mass existing within the IMCB also helped the learning process through stimulating discussions with seasoned experts in exciting topics such as signal transduction and cell cycle processeIn addition to the increased collaboration, the intellectual critical mass existing within the IMCB also helped the learning process through stimulating discussions with seasoned experts in exciting topics such as signal transduction and cell cycle processein exciting topics such as signal transduction and cell cycle processes.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

Surprisingly, the application of larval oral secretions inhibited the transduction of calcium signals to neighboring leaves in the experiment.

FosB is a transcription factor in the brain which, together with other molecules, is involved in so - called signal transduction (transmission of stimuli to the cells), that is to say conveys genetic information between the cells and also determines whether certain genes are activated or not.

Epidermal growth factor receptor (EGFR) signal transduction plays a major role in growth, proliferation and differentiation of mammalian cells.

The isoforms beta ARK - 2 and beta - arrestin - 2 are highly enriched in and localized to the dendritic knobs and cilia of the olfactory receptor neurons where the initial events of olfactory signal transduction occur.

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

In 1995, I began graduate studies on signal transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 200In 1995, I began graduate studies on signal transduction by growth factors and receptor tyrosine kinases in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 200in the laboratory of Graeme Guy at the Institute of Molecular and Cell Biology (IMCB) in Singapore, obtaining my PhD in 200in Singapore, obtaining my PhD in 200in 2000.

The cells in your body are sensing their environment through signal transduction.

Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis, signal transduction molecules, and transcription factors.

Intra - and intermolecular signal transduction mechanisms in membrane - embedded (photo --RRB- receptor / transducer complexes are studied using the photoreceptor / transducer complex NpSRII / NpHtrII, which is responsible for the photoactive behavior of the halophilic archaeon Natronomonas pharaonis.

A well - known class of proteins may fill in the dotted lines that connect signal transduction pathways to the genes they regulate.

Clara Franzini — Armstrong writes about Annemarie Weber, «a major contributor to the renaissance of muscle biology research in the 1950s to 1970s, when the components of the contractile machinery were identified; novel views of muscle contraction and regulation were elucidated; and principles of energy transduction, motility and intracellular signaling common to all cells were revealed.»

His graduate and postdoctoral work led to seven first author papers in the Journal of Biological Chemistry, including four back - to - back papers on fundamental characterization of arachidonic acid pathways, and a Cell paper, which was the first to demonstrate cAMP - independent G protein participation in receptor - mediated signal transduction.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

The involvement of NF - κB in β - interferon gene regulation reveals its role as widely inducible mediator of signal transduction.

Inhibition of signaling pathways, especially of the Wnt / β - catenin and hedgehog transduction cascades are newly described modalities involved in antitumor activity of the anthelminthics.

Aside of the inhibition of signal transduction, on - target repositioning assumes that the targets recognized in nematods, such as mitochondrial respiration and microtubules, are hit in cancer cells [70, 89, 90].

Sophie Jarriault did her PhD on the transduction of the Notch signal in mammals in Alain Israël laboratory at the Pasteur Institute, Paris.

Given the predominant role for DAG on regulating Ras / Erk and PKC - θ signaling and Cbl - b for regulating PI (3) K signaling, we hypothesized that T cells deficient in DGKζ or Cbl - b would alter TCR signal transduction through distinct mechanisms, such that DGKζ - deficient T cells would demonstrate strongly enhanced Ras / ERK activation, but only modestly enhanced NF - κB activation, and Cbl - b — deficient T cells would demonstrate modestly enhanced Ras / ERK activation and strongly enhanced NF - κB activation.

Deletion of DGKζ from T cells results in prolonged TCR signal transduction downstream of DAG, resulting in enhanced activation of Ras, increased effector T cell proliferation, and amplified cytokine production, which leads to increased antitumor activity against s.c. implanted EL4 tumors or murine mesothelioma (12, 16, 17).

This revealed design principles of the endosomal system and the role of the endosomal network in signal transduction.

Furthermore, niclosamide inhibited not only signal transduction, but also targeted mitochondria in cancer cells resulting in cell cycle arrest, growth inhibition and apoptosis [49 - 51].

The Role of Rac1 in Platelet Signal Transduction and Function.

Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c - Kit in small cell lung cancer cells.

Nuclear accumulation of the AT < sub > 1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation.