Sentences with phrase «signal transduction pathway»

Recent studies have shown that ALA has a positive impact on insulin action (via the insulin signal transduction pathway) and muscle glucose transport, especially in people whose insulin function is suboptimal, i.e. have developed insulin resistance.

Our finding that Gasp constitutively associated with Grb2 is quite intriguing and provides some possible links to hypothesize its function in positive selection, because Grb2 is an important adaptor for Sos in the TCR - mediated signal transduction pathway.

Background: Olfactory receptors (ORs) recognize odorant molecules and activate a signal transduction pathway that ultimately leads to the perception of smell.

We describe assembly and function of a complete synthetic signal transduction pathway in plants that links input from computationally re-designed PBPs to a visual response.

His laboratory is currently focused on characterizing signal transduction pathway abnormalities in prostate cancer, with an eye toward translational implications.

Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a signal transduction pathway that appears to involve an amino acid sensing GPR [37].

The p38 MAP kinase signal transduction pathway is an important regulator of proinflammatory cytokine production and inflammation.

Our synthetic signal transduction pathway is able to functionally link input from the computationally re-designed receptors to a plant response system, producing a prototype detector plant.

Citation: Antunes MS, Morey KJ, Smith JJ, Albrecht KD, Bowen TA, Zdunek JK, et al. (2011) Programmable Ligand Detection System in Plants through a Synthetic Signal Transduction Pathway.

Cbl - b is an E3 ubiquitin ligase that targets multiple components of the TCR signal transduction pathway for degradation through the proteasome to facilitate termination of TCR signaling (19, 20).

The actin cytoskeleton mediates these responses, but the signal transduction pathway leading to chloroplast movement and the mechanism of chloroplast motility is not entirely understood.

The researchers examined the crystal structure of the complex of SeV C protein and transcription factor STAT1, and found that SeV C protein inhibits the signal transduction pathway of interferon gamma.

My postdoctoral work involved signal transduction pathways that regulate chemotaxis.

Computational biology; use of control and information theory to study signal transduction pathways.

A well - known class of proteins may fill in the dotted lines that connect signal transduction pathways to the genes they regulate.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

Anticancer activities of several anthelminthics attracted considerable interest, especially their capacity to target signal transduction pathways of CSCs / TICs of several tumor types.

Growth of osteosarcoma cells was inhibited by this drug by targeting of multiple signal transduction pathways [41].

Murat completed his PhD at NCSU focusing on systems biology of growth factor - mediated signal transduction pathways.

The current project will use high - resolution mass spectrometry - based metabolomics approaches to measure temporal and spatial changes of metabolic pathways in the RPE and retina under both physiological and disease conditions, with a focus on mTOR - mediated signal transduction pathways.

We study the signal transduction pathways regulating cell growth and proliferation, with an emphasis on kinase enzymes.

Vorinostat interferes with the signaling transduction pathway of T - cell receptor and synergizes with phosphoinositide - 3 kinase inhibitors in cutaneous T - cell lymphoma

Some examples of such processes are signal transduction pathways, the cell cycle and checkpoints, and apoptosis.

One mechanism could be to differentially regulate the molecular components involved in cue detection, such as ORs or VRs [20] or in known elements of their signal transduction pathways, under the control of sex - specific hormones.

Because Syk is expressed in many kinds of hematopoietic lineage cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.

The gene expression viewer has proven to be an ideal tool for comparing gene family members, genes whose products participate in ligand — receptor interactions, and genes involved in signal transduction pathways.

While it is true that amino acids were long considered simply substrates for protein synthesis, they have more recently shown to also act as modulators of intracellular signal transduction pathways that are typically associated with growth - promoting hormones such as insulin and IGF - 1.

Not exact matches

Bowen's lab studied several sigma receptor areas, including signal - transduction pathways, novel binding elements (both agonists and antagonists), and clinical applications.

His graduate and postdoctoral work led to seven first author papers in the Journal of Biological Chemistry, including four back - to - back papers on fundamental characterization of arachidonic acid pathways, and a Cell paper, which was the first to demonstrate cAMP - independent G protein participation in receptor - mediated signal transduction.

Dr. Levitsky: Other sections under the Oncology Discovery and Translation Area (DTA) focus on anti-angiogenesis, small molecule inhibitors of the p53 pathway, apoptosis, signal transduction, and the tumor microenvironment.

Inhibition of signaling pathways, especially of the Wnt / β - catenin and hedgehog transduction cascades are newly described modalities involved in antitumor activity of the anthelminthics.

Signaling pathways were inhibited in osteosarcoma and, especially, Wnt / β - catenin signal transduction in ovarian cancer cells and via GSK3 and STAT3 in CSCs and colon cancer [41, 47, 50, 52, 53].

Furthermore, the hedgehog pathway, a reactivated embryonic pathway in cancer cells, was reported as pyrvinium - sensitive signal transduction mechanism [65].

Phosphotransfer - mediated signaling pathways, involved in signal transduction, have been identified in Pseudomonas as the two - component GacS / GacA global regulatory system (39).

With refinement of signal transduction components, stronger and more specific signaling pathways may be possible.

Countering the prevailing theory that cellular hydrogen peroxide signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive oxygen species (ROS) in fact triggers a distinct signal transduction cascade under control of the mitochondrial respiratory chain — the Syk pathway — that regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.

Helicobacter pylori effector protein CagA activates the signal transduction and activator of transcription 3 (STAT3) signaling pathway: a potential mechanism for gastric cancer development.

Berberine improves insulin signal transduction by stimulating glucose intake via the activation of the AMP - activated protein kinase pathway.