Sentences with phrase «signal transduction pathways in»
We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.
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We describe assembly and function of a complete synthetic signal transduction pathway in plants that links input from computationally re-designed PBPs to a visual response.
Not exact matches
A well - known class of proteins may fill in the dotted lines that connect signal transduction pathways to the genes they regulate.
His graduate and postdoctoral work led to seven first author papers in the Journal of Biological Chemistry, including four back - to - back papers on fundamental characterization of arachidonic acid pathways, and a Cell paper, which was the first to demonstrate cAMP - independent G protein participation in receptor - mediated signal transduction.
Inhibition of signaling pathways, especially of the Wnt / β - catenin and hedgehog transduction cascades are newly described modalities involved in antitumor activity of the anthelminthics.
Signaling pathways were inhibited in osteosarcoma and, especially, Wnt / β - catenin signal transduction in ovarian cancer cells and via GSK3 and STAT3 in CSCs and colon cancer [41, 47, 50, 52, 53].
The current project will use high - resolution mass spectrometry - based metabolomics approaches to measure temporal and spatial changes of metabolic pathways in the RPE and retina under both physiological and disease conditions, with a focus on mTOR - mediated signal transduction pathways.
Furthermore, the hedgehog pathway, a reactivated embryonic pathway in cancer cells, was reported as pyrvinium - sensitive signal transduction mechanism [65].
Phosphotransfer - mediated signaling pathways, involved in signal transduction, have been identified in Pseudomonas as the two - component GacS / GacA global regulatory system (39).
Citation: Antunes MS, Morey KJ, Smith JJ, Albrecht KD, Bowen TA, Zdunek JK, et al. (2011) Programmable Ligand Detection System in Plants through a Synthetic Signal Transduction Pathway.
Countering the prevailing theory that cellular hydrogen peroxide signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive oxygen species (ROS) in fact triggers a distinct signal transduction cascade under control of the mitochondrial respiratory chain — the Syk pathway — that regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.
Vorinostat interferes with the signaling transduction pathway of T - cell receptor and synergizes with phosphoinositide - 3 kinase inhibitors in cutaneous T - cell lymphoma
One mechanism could be to differentially regulate the molecular components involved in cue detection, such as ORs or VRs [20] or in known elements of their signal transduction pathways, under the control of sex - specific hormones.
His laboratory is currently focused on characterizing signal transduction pathway abnormalities in prostate cancer, with an eye toward translational implications.
Because Syk is expressed in many kinds of hematopoietic lineage cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.
Our finding that Gasp constitutively associated with Grb2 is quite intriguing and provides some possible links to hypothesize its function in positive selection, because Grb2 is an important adaptor for Sos in the TCR - mediated signal transduction pathway.
The gene expression viewer has proven to be an ideal tool for comparing gene family members, genes whose products participate in ligand — receptor interactions, and genes involved in signal transduction pathways.
Recent studies have shown that ALA has a positive impact on insulin action (via the insulin signal transduction pathway) and muscle glucose transport, especially in people whose insulin function is suboptimal, i.e. have developed insulin resistance.