Anticancer activities of several anthelminthics attracted considerable interest, especially their capacity to target
signal transduction pathways of CSCs / TICs of several tumor types.
The researchers examined the crystal structure of the complex of SeV C protein and transcription factor STAT1, and found that SeV C protein inhibits
the signal transduction pathway of interferon gamma.
Vorinostat interferes with
the signaling transduction pathway of T - cell receptor and synergizes with phosphoinositide - 3 kinase inhibitors in cutaneous T - cell lymphoma
Not exact matches
Computational biology; use
of control and information theory to study
signal transduction pathways.
A well - known class
of proteins may fill in the dotted lines that connect
signal transduction pathways to the genes they regulate.
The actin cytoskeleton mediates these responses, but the
signal transduction pathway leading to chloroplast movement and the mechanism
of chloroplast motility is not entirely understood.
His graduate and postdoctoral work led to seven first author papers in the Journal
of Biological Chemistry, including four back - to - back papers on fundamental characterization
of arachidonic acid
pathways, and a Cell paper, which was the first to demonstrate cAMP - independent G protein participation in receptor - mediated
signal transduction.
We are focusing on a few key molecular
pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase)
signal transduction pathways in stemness and migration
of these tumor cells, 3) Novel mitogenic
signaling pathways that are specific to GSCs, and 4) Identification
of radio - and chemo - sensitizing
pathway to maximize therapeutic efficacy.
Dr. Levitsky: Other sections under the Oncology Discovery and Translation Area (DTA) focus on anti-angiogenesis, small molecule inhibitors
of the p53
pathway, apoptosis,
signal transduction, and the tumor microenvironment.
Growth
of osteosarcoma cells was inhibited by this drug by targeting
of multiple
signal transduction pathways [41].
Inhibition
of signaling pathways, especially
of the Wnt / β - catenin and hedgehog
transduction cascades are newly described modalities involved in antitumor activity
of the anthelminthics.
Murat completed his PhD at NCSU focusing on systems biology
of growth factor - mediated
signal transduction pathways.
Cbl - b is an E3 ubiquitin ligase that targets multiple components
of the TCR
signal transduction pathway for degradation through the proteasome to facilitate termination
of TCR
signaling (19, 20).
The current project will use high - resolution mass spectrometry - based metabolomics approaches to measure temporal and spatial changes
of metabolic
pathways in the RPE and retina under both physiological and disease conditions, with a focus on mTOR - mediated
signal transduction pathways.
With refinement
of signal transduction components, stronger and more specific
signaling pathways may be possible.
Countering the prevailing theory that cellular hydrogen peroxide
signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive oxygen species (ROS) in fact triggers a distinct
signal transduction cascade under control
of the mitochondrial respiratory chain — the Syk
pathway — that regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.
Helicobacter pylori effector protein CagA activates the
signal transduction and activator
of transcription 3 (STAT3)
signaling pathway: a potential mechanism for gastric cancer development.
Some examples
of such processes are
signal transduction pathways, the cell cycle and checkpoints, and apoptosis.
The p38 MAP kinase
signal transduction pathway is an important regulator
of proinflammatory cytokine production and inflammation.
Increased expression
of transcription factor ATF2 — which is required for the amino acid depletion responses
of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a
signal transduction pathway that appears to involve an amino acid sensing GPR [37].
One mechanism could be to differentially regulate the molecular components involved in cue detection, such as ORs or VRs [20] or in known elements
of their
signal transduction pathways, under the control
of sex - specific hormones.
We describe assembly and function
of a complete synthetic
signal transduction pathway in plants that links input from computationally re-designed PBPs to a visual response.
Background: Olfactory receptors (ORs) recognize odorant molecules and activate a
signal transduction pathway that ultimately leads to the perception
of smell.
Because Syk is expressed in many kinds
of hematopoietic lineage cells and involved in various ITAM - mediated
signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.
Berberine improves insulin
signal transduction by stimulating glucose intake via the activation
of the AMP - activated protein kinase
pathway.
While it is true that amino acids were long considered simply substrates for protein synthesis, they have more recently shown to also act as modulators
of intracellular
signal transduction pathways that are typically associated with growth - promoting hormones such as insulin and IGF - 1.