Sentences with phrase «signal transduction proteins»
Heterotrimeric guanine nucleotide — binding protein (G protein)-- coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane.
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Among these was the protein VGLUT1, which is essential for signal transduction in specific nerve cells.
The researchers examined the crystal structure of the complex of SeV C protein and transcription factor STAT1, and found that SeV C protein inhibits the signal transduction pathway of interferon gamma.
It is expected that the molecular mechanisms underlying the inhibition of interferon signal transduction by C proteins would then be fully identified.
Outer membrane proteins have crucial physiological and structural functions, among them nutrient acquisition, secretion, signal transduction, outer membrane biogenesis, and motility.
Recent studies such as ours, however, establish protein phosphatases as positive and essential regulators of signal transduction, with remarkable substrate specificity and coordinated activities.
It is a rare autoimmune disease that results in the body producing antibodies against the NMDA receptor, a protein that plays an important role in signal transduction in the brain.
During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.
Signal transduction through the T - lymphocyte CD4 receptor involves the activation of the internal membrane tyrosine - protein kinase p56lck.
Nicholas Tonks Posttranslational modification; phosphorylation; phosphatases; signal transduction; protein structure and function
A well - known class of proteins may fill in the dotted lines that connect signal transduction pathways to the genes they regulate.
His graduate and postdoctoral work led to seven first author papers in the Journal of Biological Chemistry, including four back - to - back papers on fundamental characterization of arachidonic acid pathways, and a Cell paper, which was the first to demonstrate cAMP - independent G protein participation in receptor - mediated signal transduction.
Linda Van Aelst Signal transduction; Ras and Rho proteins; tumorigenesis; neural development and disorders
Immunophilins are now known to function at the crossroads of protein folding and trafficking, and signal transduction.
His academic research focused on gene regulation and signal transduction mediated by ion channels and G proteins.
Moffat and colleagues were the first to conduct time - resolved crystallography and developed photoactive yellow protein as a paradigm for light - dependent signal transduction in biology.
Recently, interest has developed regarding the possibility of targeting intracellular inhibitory proteins to improve T cell activity against cancer, including diacylglycerol kinase ζ (DGKζ)(9, 10) and Casitas b - lineage proto - oncogene b (Cbl - b)(11), which attenuate signal transduction events downstream of the TCR and CD28.
My research investigates the role of a particular protein we initially thought was just a «dead» enzyme as a regulator in signal transduction cascades (cellular communication).
Our synthetic signal transduction system was built using a modular assembly of bacterial and plant protein domains.
Homer 1, an actin binding protein that is induced by BDNF [72], belongs to a family of scaffolding proteins that localize at the postsynaptic density (PSD)[73, 74] and is believed to play a critical role in signal transduction, synaptogenesis and receptor trafficking at synapses [75].
Drugs like Gleevec ®, known as signal transduction inhibitors, work by «turning off» specific proteins in cancer cells that cause cancer cells to grow and multiply.
CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis.
Helicobacter pylori effector protein CagA activates the signal transduction and activator of transcription 3 (STAT3) signaling pathway: a potential mechanism for gastric cancer development.
In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10
Death - associated protein kinase (DAPK) and signal transduction: fine - tuning of autophagy in Caenorhabditis elegans homeostasis.
This work revealed new roles for XBP - 1 in regulating signal transduction through the B cell receptor; in regulating the expression of important transcription factors in B cells; in maintaining proper lipid synthesis and protein glycosylation in B cells; and in colonization of stimulated B cells into the bone marrow for sustention of antibody production.
His laboratory focuses on the roles of reversible protein modifications that are involved in modulating signal transduction, chromatin dynamics and gene activation.
It remains to be elucidated whether differences in translation and / or protein modification of receptors or signal transduction machinery underlie sexually dimorphic detection of pheromones.
Several projects in the area of signal transduction, fluorescent proteins engineering, optogenetics and advanced microscopy are available.
Berberine improves insulin signal transduction by stimulating glucose intake via the activation of the AMP - activated protein kinase pathway.
While it is true that amino acids were long considered simply substrates for protein synthesis, they have more recently shown to also act as modulators of intracellular signal transduction pathways that are typically associated with growth - promoting hormones such as insulin and IGF - 1.
Additional upregulated signal transduction related genes encoded proteins polycystin - 1L1, MLP and LIM regulatory proteins, fibrillins or related proteins containing Ca2 + - binding EGF - like domains, Ca2 + / Mg2 + - permeable cation channel, and other differentially expressed putative transcripts that may play a role in cellular signaling, including known extracellular proteins c - type lectin and collagen (see electronic supplementary material, table S5).