Not exact matches
In addition to the increased collaboration, the intellectual critical mass existing within the IMCB also helped the learning process through stimulating discussions with seasoned experts in exciting topics
such as
signal transduction and cell cycle processes.
Recent studies
such as ours, however, establish protein phosphatases as positive and essential regulators of
signal transduction, with remarkable substrate specificity and coordinated activities.
Similarly, Bernaudin et al. [43] found increased expression of 18 genes in the neonatal rat brain following hypoxia (8 % O2 for 3 h) including several known hypoxia inducible genes
such as MAP kinase phosphatase - 1 (MKP - 1), several HIF - 1 target genes including VEGF and GLUT - 1, genes implicated in apoptosis,
signal transduction molecules, and transcription factors.
TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced
signalling cascades, including human cell lines transfected with PAMPs
such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated
signal transduction, and cell lines that provide insight into the intracellular
signalling cascades of innate immune receptors.
Aside of the inhibition of
signal transduction, on - target repositioning assumes that the targets recognized in nematods,
such as mitochondrial respiration and microtubules, are hit in cancer cells [70, 89, 90].
Given the predominant role for DAG on regulating Ras / Erk and PKC - θ
signaling and Cbl - b for regulating PI (3) K
signaling, we hypothesized that T cells deficient in DGKζ or Cbl - b would alter TCR
signal transduction through distinct mechanisms,
such that DGKζ - deficient T cells would demonstrate strongly enhanced Ras / ERK activation, but only modestly enhanced NF - κB activation, and Cbl - b — deficient T cells would demonstrate modestly enhanced Ras / ERK activation and strongly enhanced NF - κB activation.
Approaches successful in other systems,
such as modeling
signal transduction and synthetic biology methodologies [32] could improve future generations of detector plants by enhancing
signal transmission and providing means to deal with biological «noise».
Some examples of
such processes are
signal transduction pathways, the cell cycle and checkpoints, and apoptosis.
Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes
such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a
signal transduction pathway that appears to involve an amino acid sensing GPR [37].
One mechanism could be to differentially regulate the molecular components involved in cue detection,
such as ORs or VRs [20] or in known elements of their
signal transduction pathways, under the control of sex - specific hormones.
BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced
signalling cascades, including human cell lines transfected with PAMPs
such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated
signal transduction, and cell lines that provide insight into the intracellular
signalling cascades of innate immune receptors.
While it is true that amino acids were long considered simply substrates for protein synthesis, they have more recently shown to also act as modulators of intracellular
signal transduction pathways that are typically associated with growth - promoting hormones
such as insulin and IGF - 1.