Aβ is believed to penetrate neuronal plasma membranes, where it leads to lipid peroxidation.10 It has also been implicated in deactivating a subunit of the pyruvate dehydrogenase complex, thereby inhibiting
conversion of pyruvate to acetyl CoA and the eventual production of cellular energy as ATP.32 Another way Aβ affects glucose metabolism in the brain is that fragments of Aβ disrupt insulin
signaling by binding to neuronal synapses, which alters their shape and function.15, 38 Insulin receptors are abundant at synapses, so if the integrity of the synapse itself has been compromised, the receptors won't function effectively.
TSH is just the
signal, it doesn't tell us how your thyroid is responding to that
signal, trouble with
conversion of made thyroid hormone (T4) into active thyroid hormone (T3), how much of that is free and available for action, and a host of other issues are not seen
by just looking at TSH.