Sentences with phrase «signaling axis»

These findings support a role for the ABL kinase — STAT5 signaling axis in breast cancer metastasis.
The binding of a BRAF mutation to the ER stress gatekeeper GRP78 is a new and unexpected molecular interaction driving resistance, and establishes a new signaling axis that has multiple drug targets, Dr. Amaravadi said.
«Our work shows that the PKCepsilon / Nanog / Bmi1 signaling axis is essential to promote head and neck cancer,» Pan says.
«We think it's likely that this sort of signaling axis can coordinate aging not only in C. elegans, but in many other organisms as well.»
Inhibition of cell migration and invasion of enzalutamide - resistant prostate cancer cells was effected by niclosamide through its effects on the androgen receptor (AR)- STAT3 signaling axis [40].
Dysfunction of the SDF - 1 / CXCR4 signaling axis is a major cause of WHIM syndrome because it hinders the development of B - lymphocytes and myeloid cells [45].
MicroRNA -17-92 regulates myoblast proliferation and differentiation by targeting the ENH1 / Id1 signaling axis.
New research suggests that potentiating the AKT - mTOR signaling axis can boost tenogenesis of mesenchymal stem cells and improve current tendon repair strategies
Furthermore, stimulation of ERK5 via the MEK5 — ERK5 signaling axis was shown to suppress expulsion.
Ongoing projects aim to define the involvement of these two signalling axes in cancer and to investigate whether the endocytic function of Numb is relevant to its tumour suppressor function.
«This study defines a signaling axis that is essential for head and neck cancer progression, and our findings show that this axis may be disrupted at three key steps,» says principal investigator Quintin Pan, PhD, associate professor of otolaryngology at the OSUCCC — James.
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