Sentences with phrase «signaling cascade»

An extensive toolbox of products for your flow cytometry experiments is available, including Super Bright polymer dyes for violet laser — based multicolorflow cytometry; eFluor organic dyes for multicolor applications; cocktails of conjugated antibodies for multispectral flow analysis; Phospho Flow antibodies for measuring signaling cascades in individual cells; Fox P3 reagents for intracellular flow cytometry analysis; antibodies reported to work in CyTOF; and various support reagents.

ADAMTS1 and MMP1 proteolytically engage EGF - like ligands in an osteolytic signaling cascade for bone metastasis

The behavior of FLS is governed by intracellular signaling cascades, which rely on the presence (or absence) of small phosphate groups to transmit signals through the cell.

This is a very important - again, another transcription factor that regulates not glucose metabolism so much, but lipid metabolism and lipogenesis; and this is also under the regulation of insulin signaling cascade.

Our primary focus is on signaling cascades via Galphaq, which is explained in more detail below.

Multiple compounds with the Super DMZ 5.0 formula have been clinically demonstrated to activate / inhibit key signaling cascades involved in the regulation of blood glucose, glycogen synthesis, fatty acid synthesis, transcriptional regulation, and cytokine - mediated inflammation.

STAT3 is a major adaptor, or actually it's a transcription factor that's activated by JAK2 kinase, and this leads to a so - called leptin signal, and the leptin signaling cascade.

The team discovered that the pain signals from a peripheral injury combined with subsequent morphine treatment worked together to cause a glial cell signaling cascade.

Our laboratory has spent many years delineating the regulation of translation initiation by the mTORC1 and ERK signaling cascades during LTP, LTD, and memory formation in the hippocampus.

Researchers found that estrogen upregulates, and progesterone downregulates most of the same signaling cascade stimulated by MSH.

The anti-apoptotic effect of BES was dependent on the activation of the PI3K / Akt signaling cascade and an increase in brain - derived neurotrophic factor (BDNF) production.

So this is a very important regulator of multiple signaling cascades.

The megakaryocyte / platelet - specific enhancer of the a2b1 integrin gene: Two tandem AP1 sites and the mitogen activated protein kinase signaling cascade.

It has been observed that this pathway when is activated by upstream signaling cascades [such as growth factor receptors and G - protein coupled receptors (GPCRs)-RSB-, leads to cell proliferation, differentiation and migration.

ERK is the last step in the RAS - RAF - MEK - ERK signaling cascade.

Also mentioned here is that there is a key signaling cascade, which I've already mentioned the JAK / STAT pathway that regulates signaling.

Today, I will be focusing on metabolic signaling cascades, particularly insulin and leptin signaling pathways.

In subsequent experiments, the Einstein team deciphered other parts of the Rac1 signaling cascade during invasion and showed that this signaling mechanism is regulated differently in normal breast epithelial cells.

Scientists at the University of Bonn and the Hebrew University of Jerusalem (Israel) have decoded a central signal cascade associated with epileptic seizures.

Bohn noted isoquinolinone 2.1 is one example of a new class of «biased» kappa agonists that avoid many central nervous system side effects by preferentially activating a G protein - mediated signaling cascade without involving another system based on β - arrestin protein interactions.

Frigo and his team demonstrated in this study that androgens take control of the AMPK signaling cascade, a master regulator of metabolism, to increase prostate cancer cell growth.

«The androgen signaling cascade is important for understanding early and late - stage prostate cancer progression.

The researchers also tested whether learning and memory deficits could be corrected using drugs that calm the overactive signaling cascades.

Dr. Hadas Reuveni, the CEO of TyrNovo, a startup company formed for the clinical development of NT219, and Prof. Alexander Levitzki from the Department of Biological Chemistry at the Hebrew University, with their research teams, discovered a new set of compounds that inhibit the activity of the IGF1 signaling cascade in a unique and efficient mechanism, primarily for cancer treatment, and defined NT219 as the leading compound for further development.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

The scientists» model looks at the EGFR signaling cascade to investigate crosstalk between EFGR signaling and EMT in cell culture models of human breast epithelium.

For a long time, scientists were convinced that GPCRs influence the activity of the cell via activation of various intracellular signalling cascades while sitting at the cell surface.

Rutin functions as a cold mimetic through activating a SIRT1 - PGC1α - Tfam signaling cascade and increasing mitochondrial number and UCP1 activity in BAT.

T. gondii has the capacity to modulate host signaling cascades and remodel its host cells» transcriptomes and proteomes profoundly.

Detailed biochemical and sophisticated imaging experiments are employed to delineate the molecular signaling cascades that couple receptors to the translational apparatus during long - lasting synaptic plasticity in the hippocampus, amygdala, cortex, and striatum, and whether these types of translational control are required for memory formation, social behaviors, and behavioral flexibility.

During infection T. gondii parasites not only alter the transcriptional profile of the host cells but also modulate host - signaling cascades at the protein level by secreting a battery of kinase and pseudokinase proteins into the host cell potentially modifying the phosphorylation status and function of many host proteins.

The NAADP antagonist partially inhibited oxytocin induced contraction, proving that well established Gq - protein - coupled oxytocin receptor does not solely activate IP3 signalling cascade but also through NAADP signalling.

For instance, oncogenic activation of the WNT / beta - catenin signaling cascade, which often comprises cooperating genetic and / or epigenetic events, is the most common tumour - initiating hallmark in neoplastic intestinal stem cells for sporadic colorectal cancer.

BRAF is a serine / threonine kinase that is part of the MAPK signaling cascade found downstream of RAS; it is known activate MEK by phosphorylation, which in turn activates ERK also by phosphorylation.

Because interference with the gp130 / Stat3 signaling cascades limits the expansion of such intestinal (cancer) stem cells, the Stat3 - mediated non-oncogene addiction dependency can be therapeutically targeted in WNT - dependent tumourigenesis or in regenerative medicine.

In the past decade we have identified diverse signaling cascades that converge on gephyrin scaffold to regulate its scaffolding property, and in turn GABAergic neurotransmission.

Bernard - Trifilo JA, Kramar EA, Torp R, Lin CY, Pineda EA, Lynch G, Gall CM (2005) Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology.

Melanocytes have the capacity to respond to a diverse number of extracellular signals, including UVR, endocrine signaling cascades that occur during pregnancy, micro-environments of the stem cell hair bulge vs. differentiated hair follicle niches, and hypoxic conditions found in metastatic melanoma tumors.

This research is important not only because it uncovers the molecular link between Vegf and Dll4, but also because it shows how signaling cascades like this one can direct genes — which are normally active throughout the embryo — to perform tasks only in specific cell types.

We further extended our analysis of pluripotency gene expression to a much larger scale to potentially identify similar signaling cascades that might be conserved between hNSCs and hESCs.

LeDoux, J.E., Liston, C., and Klann, E. (2017) Activation of a novel p70 S6 kinase 1 - dependent signaling cascade in the basal nucleus of the amygdala is required for the acquisition of extinction memory.

«Instead, the Vegf signaling cascade alerts only those MAPKs and ETS factors within the realm of Dll4 — assuring only the correct cells grow and differentiate over time to form arteries.»

The epidermal growth factor receptor (EGFR) pathway is a complex signaling cascade that is involved in the development and progression of cancer.