Sentences with phrase «signaling cascades in»

«FKBP51 influences a signaling cascade in muscle tissue, which with excessive calorie intake leads to the development of glucose intolerance, i.e., the key indicator of diabetes type 2,» says Mathias Schmidt, lead researcher on the project.

LeDoux, J.E., Liston, C., and Klann, E. (2017) Activation of a novel p70 S6 kinase 1 - dependent signaling cascade in the basal nucleus of the amygdala is required for the acquisition of extinction memory.

Not exact matches

Introducing human prostate cancer cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for tumor cells to invade and grow in bone.

When mutated, BRAF, an enzyme that acts in a signaling cascade known as the MAPK / ERK pathway, becomes overactive and leads to increased cellular growth, a hallmark of cancer.

When they react to external stimuli, by binding molecules, for example, a structural transformation takes place on the inside that triggers a signalling cascade (see 2012 Nobel Prize in Chemistry).

«It's important that it all be viable — if not, not only might cells die in the center of the graft, but they can release bad signals to remaining healthy cells in an «apoptotic cascade,» essentially saying, «Conditions are horrible, let's commit suicide.»»

In subsequent experiments, the Einstein team deciphered other parts of the Rac1 signaling cascade during invasion and showed that this signaling mechanism is regulated differently in normal breast epithelial cellIn subsequent experiments, the Einstein team deciphered other parts of the Rac1 signaling cascade during invasion and showed that this signaling mechanism is regulated differently in normal breast epithelial cellin normal breast epithelial cells.

«In the case of glycoprotein hormone receptors, the family of proteins that includes the thyroid receptor, upon binding of the extracellular hormone, the intramolecular activator (p10) induces structural changes of the receptor protein, triggering activation of the intracellular signaling cascade.»

Recent research has shown that the cascade of signals in the proinflammatory immune response tend to cause the amino acid tryptophan to break down into kynurenic acid rather than serotonin, a brain chemical that influences mood.

CANTOS grew out of years of ups and downs in the heart disease field, as scientists tried to trace the role of inflammation, a complex cascade of immune signals and various white blood cells that occurs in response to wounds, infections, and more.

Multiple sclerosis (MS) is caused by immune cells that activate a cascade of chemicals in the brain, attacking and degrading the insulation that keeps neuronal signals moving.

They call this form of activation «non-ligand-dependent,» and in a complex series of biochemical and animal experiments, traced the pathway through which FER's binding to MET inside the cell sets off a cascade of cell - signaling events, all directly connected in prior research with cancer initiation, including RAC1 / PAK1 and SHP2 - ERK.

In addition to the COX enzyme pathway, Dr. Roberts says other studies have shown that aspirin blocks additional cell - signaling cascades that promote cancer development.

Frigo and his team demonstrated in this study that androgens take control of the AMPK signaling cascade, a master regulator of metabolism, to increase prostate cancer cell growth.

Activation of MC1R triggers a further cascade of specific signals within melanocytes, which ultimately leads to a boost in melanin production.

Changes in blood flow pattern, such as from plaque build - up in the arteries, initiate a cascade of conflicting signals.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

The result did not come as a total surprise because other worm genes that play a role in agingsuch as daf - 2are part of the same signaling cascade.

Pheromones are detected by the so - called vomeronasal organ, which sits in the nasal cavity and sets off a cascade of nerve signals that ends in the accessory olfactory bulb, the organ that processes pheromones.

Like a cascade, after the first molecule in a pathway receives a signal, it activates another molecule and so forth until the cell function is carried out.

These signals prompt a cascade of defenses designed to kill the pathogen; however, in a person with autoimmune disease, these inflammatory responses inexplicably turn against normal tissue.

The scientists» model looks at the EGFR signaling cascade to investigate crosstalk between EFGR signaling and EMT in cell culture models of human breast epithelium.

The anti-apoptotic effect of BES was dependent on the activation of the PI3K / Akt signaling cascade and an increase in brain - derived neurotrophic factor (BDNF) production.

Removal of the phosphates by PTP - 1B should therefore turn off the signal cascade, and that's what researchers had found in the test tube studies.

When a rod cell in the retina absorbs light, a cascade of reactions results in a nerve signal.

The cascade produces a cell signal from a protein called interleukin - 1beta (IL - 1b), which increases the activity of pain - responsive nerve cells in the spinal cord and brain.

Rutin functions as a cold mimetic through activating a SIRT1 - PGC1α - Tfam signaling cascade and increasing mitochondrial number and UCP1 activity in BAT.

As soon as the calcium level exceeds a particular threshold value over a longer period of time, a signal cascade is triggered that initiates production of the body's tanning pigment melanin in the genetically modified cells.

Byron B. Goldstein was recognized for his contributions in the field of mathematical immunology and cell biology, specifically in modeling cell signaling cascades, pursuing cutting - edge research in cell activation, cell - signaling, cell surface receptor - ligand interactions, and the generation of allergic responses.

Detailed biochemical and sophisticated imaging experiments are employed to delineate the molecular signaling cascades that couple receptors to the translational apparatus during long - lasting synaptic plasticity in the hippocampus, amygdala, cortex, and striatum, and whether these types of translational control are required for memory formation, social behaviors, and behavioral flexibility.

TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

Moreover; in addition to the various mutations that have been highlighted and interact in key component of signaling cascades, different types of RNAs have been shown to be involved in melanoma pathogenesis such as: miRNAs and lncRNAs [48, 49].

Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen - activated protein kinase signaling cascades.

Inhibition of signaling pathways, especially of the Wnt / β - catenin and hedgehog transduction cascades are newly described modalities involved in antitumor activity of the anthelminthics.

When TLR2 binds Mycoplasma, it kicks off a signaling cascade that results in NF - kappaB activation.

Elucidated a cascade of transcriptional and signaling events that control the early steps of cardiomyocyte differentiation in a chamber - specific manner.

In the past decade we have identified diverse signaling cascades that converge on gephyrin scaffold to regulate its scaffolding property, and in turn GABAergic neurotransmissioIn the past decade we have identified diverse signaling cascades that converge on gephyrin scaffold to regulate its scaffolding property, and in turn GABAergic neurotransmissioin turn GABAergic neurotransmission.

Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase - 3β and a caspase -9-dependent apoptosis in cerebellar granule neurons.

Previously in a mutated BRAF mouse model, ablation of PTEN led to melanoma development [45], suggesting the PI3K / AKT signaling cascade is one of the critical players in melanoma turmorigenesis.

In particular, the cAMP signaling cascade directs adaptive cellular responses to a variety of stress stimuli via a combination of acute affects arising from GS - protein coupled receptor (GPCR)- mediated activation of PKA and long - term affects resulting from transcriptional reprogramming directed by CREB and the CREB Regulated Transcription Coactivators (CTRCs).

My research investigates the role of a particular protein we initially thought was just a «dead» enzyme as a regulator in signal transduction cascades (cellular communication).

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

ADAMTS1 and MMP1 proteolytically engage EGF - like ligands in an osteolytic signaling cascade for bone metastasis

Our laboratory has spent many years delineating the regulation of translation initiation by the mTORC1 and ERK signaling cascades during LTP, LTD, and memory formation in the hippocampus.

Melanocytes have the capacity to respond to a diverse number of extracellular signals, including UVR, endocrine signaling cascades that occur during pregnancy, micro-environments of the stem cell hair bulge vs. differentiated hair follicle niches, and hypoxic conditions found in metastatic melanoma tumors.

Mechanical deformations associated with embryonic morphogenetic movements have been suggested to actively participate in the signaling cascades regulating developmental gene expression.

Based on these sources, we identify 497 genes with possible immune function in Nasonia (Table S1), including 75 encoding effectors (AMPs, proteins in the prophenoloxidase cascade, transferrins, and peroxidases), 96 encoding recognition proteins (including PGRPs, TEPs, Nimrod - like proteins, and numerous lectins), 101 encoding signaling proteins, and 225 encoding proteases or protease inhibitors.

In biology, a signaling cascade is a series of chain reactions that help cells amplify a particular signal — like a domino effect.

Wnt signaling intimately interacts with the BMP and Notch cascades to drive proliferation and inhibit differentiation in intestinal crypts and adenomas (17, 20).

Countering the prevailing theory that cellular hydrogen peroxide signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive oxygen species (ROS) in fact triggers a distinct signal transduction cascade under control of the mitochondrial respiratory chain — the Syk pathway — that regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.