Sentences with phrase «signaling complex»

The award recognizes his work on the molecular regulation of lipid signaling complexes.

In this context, we have identified microcompartmentation of signaling complexes in the plasma membrane and in endosomes as important determinants for receptor dynamics and signaling activity.

Control of T cell signaling occurs through both positive and negative regulation, as well as through the actions of molecular scaffolds that contribute to the formation of signaling complexes.

Binding to the family of NOD - like receptors triggers the assembly of large protein signaling complexes called inflammasomes, leading infected cells to die and produce inflammatory mediators.

Molecular view of the membrane receptor signaling complex controlling plant organ shedding.

To study an even larger signaling complex surrounding the switch, the team is expanding these simulations on the 27 - petaflop, CPU — GPU machine Titan — the nation's most powerful supercomputer, managed by the Oak Ridge Leadership Computing Facility at ORNL.

In this study, scientists have found that a component of the system, HOIL - 1L, is necessary for formation of the NLRP3 - ASC inflammasome signaling complex.

The remarkable tale of actress and inventor Hedy Lamarr helps signal the complex nature of innovation

Her previous work identified the scaffold protein p62 as a critical component of the mTORC1 nutrient - sensing signaling complex.

We therefore study functions of kinetochore proteins and spatio - temporal control of kinase / phosphatase signaling complexes, in particular those involved in attachment error - correction and the spindle assembly checkpoint.

Title: De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia Author: G. Kirov et al..

To achieve this goal, we developed an integrated system that enables simultaneous real - time visualization of structural reorganization in spatially - restricted signaling complexes and functional modifications of single synapses in brain circuits.

One began when University of Michigan biochemist Roger Sunahara and Stanford researcher Brian Kobilka asked Skiniotis to help characterize the structure of an activated G protein coupled receptor (GPCR) bound to a G protein trimer, a central signaling complex involved in all aspects of human physiology.

For example, when biting into an apple, the body will immediately signal a complex sequence of messages and processes to break down the apple into energy and essential structural nutrients for cellular repair and replacement.

The proteins newly revealed to be druggable belong to a variety of functional classes, including enzymes that catalyze biochemical reactions, scaffold proteins that act as hubs for other protein signaling complexes, and transcription factors that regulate gene activity.

The spatiotemporal organization of cytokine receptor signaling complexes is currently controversially debated.

«This is the first time that this specific protein - protein signaling complex has been identified in GBM, and it gives us a new potential target for drug development,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, professor and chair of the Department of Human and Molecular Genetics at the VCU School of Medicine, and director of the VIMM.

Dimers are grouped in threes to form larger units of the signaling complex, called trimers of dimers.

Unravel the mechanistic role of the associated Janus kinases in the assembly of the signaling complex.

Danish artist Julie Sass presents a cohesive body of new work as part of Copenhagen Arts Week that signals complex, painterly explorations in abstract minimalism