Sentences with phrase «signaling components ox40»

Both DAG and calcium are essential second messengers which activate downstream signaling components such as protein kinase C and calmodulin dependent kinase.

I am currently working with Zika virus and how it affects the T cell response and T cell signaling through tumor necrosis receptor (TNFR) signaling components OX40, 4 - 1BB, and CD27 in specific mouse model systems.

While it is not straightforward to directly compare the immune repertoire reported here with previous reports that have used different underlying gene models [15], [34], we do note that our inference about the number and identity of signaling components is consistent with previous annotations [15], [34], while our inference about recognition and effectors tends to reflect greater, albeit still relatively minor, differences.

While homology - based approaches are likely to be reliable for well - conserved pathways such as the core signaling components of the innate immune network, it is difficult to confidently assign function to the numerous proteases, protease inhibitors, and similarly diverse gene families in the absence of direct functional information.

Reverse transcriptase - polymerase chain reaction (RT - PCT) analysis of synthetic sensing and signaling components confirms expression of components of the sensing gene circuit.

The presence of these molecules in choanoflagellates suggests that signaling components needed to communicate between cells is evolutionarily ancient.

Scaffold proteins offer a simple, flexible strategy for regulating selectivity in pathways, shaping output behaviors, and achieving new responses from preexisting signaling components.

Characterization of one of the targets of this translation regulatory machinery, the ethylene signaling component EBF2, indicates that the signaling molecule EIN2 and the nonsensemediated decay proteins UPFs play a central role in this ethylene - induced translational response.

Within this broad topic we are particularly interested in characterising (i) the molecular mechanism by which these photoreceptors mediate light - dependent entrainment of the circadian clock, (ii) the components mediating, in a light - quality - dependent fashion, nucleocytoplasmic partitioning of phytochromes and UVR8, (iii) how phosphorylation and sumoylation of these photorecepors and other signalling components modulate red / far - red and UVB - induced signalling, and (iv) to what extent intercellular and cell - autonomous events contribute to phytochrome and UVR8 regulated photomorphogenesis.

Table 1: Trends in °C / decade of the signal components due to MEI, AOD and TSI in the regression of global temperature, for each of the five temperature records from 1979 to 2010.

We use observed estimates of the signal component of TLT changes and model estimates of climate noise to calculate timescale - dependent signal - to - noise ratios (S / N).

Not exact matches

Timing fitness classes during the workday signals to staff that management wants people to take time out from non-stop sitting, and «buy - in» from the top is the single most critical component of any wellness program, according to experts.

It said that Apple had told its iPhone X suppliers that it only wanted about 40 % of the components it had originally ordered, signaling weak initial demand for the device.

First, as there are many different wage series, a good way to evaluate evolving wage pressures is to mash them together using principal components analysis (a statistical technique that gives heavier weight to the series with the strongest signal).

The fall in the building component was quite pronounced, as had been signalled by the shift down in the volume of work approved in late 2003 and early 2004.

Generally speaking, joint market action in Treasury yields, credit spreads, commodities, and market internals provide the earliest signal of potential economic strains, followed by the new orders and production components of regional purchasing managers indices and Fed surveys, followed by real sales, followed by real production, followed by real income, followed by new claims for unemployment, and confirmed much later by payroll employment.

Although much less research exists on monk fruit and its components, preliminary studies show promise for improving insulin signaling by protecting the pancreatic insulin - releasing cells from oxidative stress (3, 4).

For the teams out West, it signals that the Warriors just added another component player to the rotation that may yield big dividends in the postseason.

HDMI cables are the only connector capable to transmitting 3D video signals from some components like a Blu - Ray 3D player to your 3D TV.

As the breast fills, compounds in the retained milk (FIL, peptides, fatty acids, and other components) signal the secretory cells to slow down milk synthesis.

ARA is a component of all cells and important for cell signaling.

It signals that states like Britain no longer enjoy what Hedley Bull identified as a central component of status as a great power: «great powers are powers recognized by others to have... special rights and duties».

@Philipp - it has non-economic political components on top of direct economic ones (inasmuch as «free college» has social and political long term implications - and so does «it's OK to default on debt» signal in terms of moral hazard).

«This is a big step in determining the identity of key components of the molecular machinery that converts sound waves into electrical signals in the inner ear,» said the study's co-senior author, Gregory Frolenkov, of the Department of Physiology at the University of Kentucky.

Eukaryotic - specific signal recognition particle and receptor components stabilize the ribosomal endoplasmic reticulum — targeting complex.

The semiconductor gallium arsenide (GaAs) is widely used, for instance in infrared remote controls, the high - frequency components of mobile phones and for converting electrical signals into light for fibre optical transmission, as well as in solar panels for deployment in spacecraft.

Now, the «smart» bandage developed by the team provides direct, noninvasive measurement of tissue oxygenation by combining three simple, compact and inexpensive components: a bright sensor molecule with a long phosphorescence lifetime and appropriate dynamic range; a bandage material compatible with the sensor molecule that conforms to the skin's surface to form an airtight seal; and an imaging device capable of capturing the oxygen - dependent signals from the bandage with high signal - to - noise ratio.

«The results are novel, as this sensitive and comprehensive testing has revealed how prenatal and early postnatal immune activation may regulate core behavioral signs associated with ASD and certain other developmental disorders through changes in signal flow between different structural components of behavior - driving neural circuits,» said Bolshakov.

For example, to tease out what various sound signals might mean, the researchers had to figure out how kelp tissues respond to sound (turns out that it's highly dependent on alginate content, a gummy cell wall component of kelp).

Steve: So when you see alcoholism in a cluster in a family group, that's a signal to you that even though there might be an environmental component, perhaps it's at least worth looking for a genetic component?

The authors hypothesize that these activities are components of cellular reconfigurations that are involved in processing communication signals essential for social organization.

«Along with the eggs, the parasitoid injects a symbiotic virus that knocks out the immune system of the caterpillar and kill the component in the caterpillar saliva that signals the plant that it is being attacked.»

Components of indoor dust may signal human fat cells to grow and may alter metabolism, potentially contributing to weight problems, researchers report July 14 in Environmental Science & Technology.

«We have identified two components of the knee joint that control bone growth, at least following injury, and we've shown that signals from these components influence distinct growth plate signaling pathways and lead to reduced bone growth,» concludes Alexandra Joyner, PhD, senior author and Developmental Biologist at Sloan Kettering.

The advance improves on a staple of modern computation known as the fast Fourier transform, or FFT, which breaks down a complex signal into its component parts — almost like describing a piano chord by identifying the individual notes that need to be played.

Extend that logic to a cell, though, and things can get ugly: Because IDPs regulate how different components of the cell communicate with one another, having extra copies floating around could leave them sending signals that shouldn't get sent.

Signals that have the fewest component frequencies, like those used for medical imaging, will see the biggest speed gains, but more complex tasks, such as video file compression, should get a substantial boost as well.

«But our findings suggest that at its evolutionary origins, handshaking might have also served to convey odor signals, and such signaling may still be a meaningful, albeit subliminal, component of this custom.»

A special feature of the new component is that not only it converts one signal into another, but it can also be used to convert multiple input signals into multiple output signals in a straightforward manner.

Already now, the optoelectronic components developed by the researchers can be used to produce light signals in the gigahertz frequency range from electric signals.

This allows current to pass in only one direction, preventing back - scattered current from interfering with other components and the forward signal.

Sometimes, they also send an output signal if no input signal is present, and the problem becomes worse when several such components are connected consecutively in a circuit.

Chloroplast, the compartment responsible for plant photosynthesis, is a key component of this signaling pathway.

The enzymes, together with a «coenzyme», conduct electrons from the enzymic reactions into components of the sensor that provide a visible signal to the user.

In order to combine biologic components in any desired sequence signal converters must be connected between them.

The target for ibrutinib, an enzyme called Bruton's tyrosine kinase (BTK), is a key component of B - cell receptor signaling.

This component of the signal has a more all - or - none character, reflecting the all - or - none character of conscious experience.

The compact electricity / light signal converter presented now meets the requirements of the next generation of computers that combine electronic components with nanophotonic waveguides.

The result is the Fourier transform, an equation that treats a time - varying signal as the sum of a series of component sine curves and calculates their amplitudes and frequencies.

Telemetry requires two components: a tag fixed to the shark and a listening station to receive the signal.