Sentences with phrase «signaling molecules with»

Suddenly, a neighbor releases signaling molecules with an attention - getting message, like the irresistible chatter of a next - door gossip who has a hot tidbit.

The two drug combination «reveals the possibilities of combining an immune signaling molecule with taking the brakes off at the same time,» said F. Stephen Hodi, MD, first author on the clinical trial report.

Not exact matches

The Serhan lab, which focuses on identifying and elucidating the structures of bioactive molecules, has made critical discoveries over the last two decades that have illuminated the biochemical signaling pathways that resolve and control inflammation and pain associated with disease and injury recovery.

When dosed with the drugs, these neurons, which produce the signaling molecule dopamine, let positively charged ions leave the cell, thereby damping the cells» hyperactive firing.

The speed with which the wave moves suggests that it travels through gap junctions and is made up either of calcium ions or some other small signaling molecule.

«Most of what we are all doing with liquid biopsies is dealing with very small numbers [of molecules], so using a poor sample extraction or nonoptimized kit can really get rid of a lot of the signal,» she says.

Now, the «smart» bandage developed by the team provides direct, noninvasive measurement of tissue oxygenation by combining three simple, compact and inexpensive components: a bright sensor molecule with a long phosphorescence lifetime and appropriate dynamic range; a bandage material compatible with the sensor molecule that conforms to the skin's surface to form an airtight seal; and an imaging device capable of capturing the oxygen - dependent signals from the bandage with high signal - to - noise ratio.

The tamed birds also had higher levels of serotonin, both a signaling molecule in the brain that may be involved with fear responses and a hormone associated with metabolism and feeding in chickens.

But when the immune system becomes activated in response to an illness or injury, glia in regions associated with pain processing seem to take on another role: They release inflammatory molecules that interact with nearby neurons to amplify pain signals.

«That upheld our hypothesis, which was that biochar could interfere with cell signaling, most likely by binding with the fatty - acid molecules that the speakers were using to broadcast their message.»

Loss of LKB1 by regulatory T cells was also associated with increased levels of signaling molecules or cytokines associated with the Th2 immune response, Kai said.

The team concludes that these signals are generated by speeding electrons produced when cosmic rays collide with molecules in the air (Physical Review Letters, DOI: 10.1103 / PhysRevLett.105.151101).

In what Grashorn calls a «serendipitous discovery», his team has worked out that these signals are generated by speeding electrons produced when cosmic rays collide with molecules in the air.

If indole allows pathogenic bacteria to withstand antibiotics, it may be possible to thwart drug resistance by blocking indole signaling with small molecules, Collins says.

Researchers still don't know how this range corresponds to their versatile functions, but being more like a string than like a lump with keyholes means that a protein can make many contacts with other molecules to regulate the network of signals that drives the cell.

But when I discussed my aspirations with established PIs — who had spent their careers learning everything they could about a particular gene or protein — I probably seemed lazy or uninterested, because I couldn't specify a particular signaling pathway or molecule - ligand interaction that I wanted to study.

In mice with pancreatic tumors, Kalbasi and other members of the team found relatively high levels of inflammatory compounds including CCL2, the signaling molecule that activates CCR2 on monocytes and macrophages to make these cells migrate to tumors.

Now, though, it is becoming clear that antibodies, signalling molecules and even immune cells often get through, sometimes with radical effects.

The pluripotent stem cells are then grown while being flooded with a molecule called Pax7 — which signals the cells to start becoming muscle.

One of the four new reported loci is expected to lower the protein expression of UBASH3A, a molecule that regulates T - cell signaling and correlates with lowering the risk of primary sclerosing cholangitis.

For the purpose of FOP drug discovery, scientists have normally focused on molecules associated with BMP signaling.

Then there's the West Palm Beach symposium, held to recruit participants for a study testing what happens when aging people get infusions of plasma (the fluid part of blood packed with signaling proteins and other molecules but no red or white cells) from young people who've taken a drug meant to activate their immune system.

During synthesis, GDF8 or myostatin, is made as a precursor which remains in a dormant state with half of the molecule holding the section of GDF8 responsible for signaling inactive, says Thompson.

By interaction with externally docking ligand molecules, external signals are transmitted into the cell.

Bacterial cells communicate with one another by using chemical signal molecules, which they synthesize and secrete into their surroundings.

This lets the experimentalists of CELIA to determine the chirality of the molecules very efficiently, with a signal 1000 times stronger than with the most commonly used method.

This is where small molecule therapeutics could be developed to interfere with the signals and suppress tumor growth.

For the study, the Bohn worked closely with TSRI chemist Thomas Bannister, PhD, to develope new potential drug molecules; they then tweaked their chemical structures to systematically vary the «bias» between the two pathways — G protein signaling and beta - arrestin recruitment.

Eventually he found that if he treated GRP cells with a special signaling molecule, they generated a type of astrocyte called GDA (glial - restricted precursor derived astrocyte).

«It's possible that if there's some problem with this molecule in patients, they will have poor alarm signaling, and they will have very poor outcomes,» he said.

«Recent work by other groups has shown that bile acids act as signalling molecules in the host, almost like a hormonal network, with an ability to influence host metabolism.

Diluting these transistor molecules with insulating carbon chains, Schn found that just one was enough to turn a signal on or off, making a rudimentary circuit element.

I ache to see your action potential in action To be blinded by the searing speed of your electric signal As it sparks from node to node To behold the violent beauty of vesicles fusing with your presynaptic membrane — Pouring their contents into your synaptic cleft How I wish to be your postsynaptic cell So that I may be flooded by your molecules

During the 2008 relapse, the researchers found that immune cells in tissues with active colitis produced large quantities of an inflammatory signaling molecule named interluekin - 17 (IL - 17), but very little IL - 22, the latter of which has been linked to wound healing and mucus production.

FosB is a transcription factor in the brain which, together with other molecules, is involved in so - called signal transduction (transmission of stimuli to the cells), that is to say conveys genetic information between the cells and also determines whether certain genes are activated or not.

They found these molecules not with optical telescopes but by tuning in with exquisitely sensitive antenna dishes that can receive the extremely faint radio signals generated by molecular clouds.

A chemical interaction with target molecules subtly alters the magnetic signal from the xenon; by detecting this change researchers can identify the molecules in a complex mixture.

«If further studies validate that these processes are critical in human breast cancers,» Koshy notes, «the possibility exists that agents that favorably modify the biophysical properties of the extracellular matrix, or that target the receptors and signaling molecules associated with how cells sense this matrix, could be used as a new avenue for the prevention or treatment of breast cancers.»

The sphingomyelin analog molecule was associated with a signaling raft domain from frame 4 to 9 (orange arrows).

When a low - energy neutrino or antineutrino from a supernova collides with a water molecule in the tank, the resulting light signal is recorded by about 100 of 13,000 photomultipliers, ultrasensitive light - detecting devices that turn a tiny flash of light into a larger recordable burst of electricity.

Researchers tag the molecule with an element that gives a characteristic signal and allows them to deduce the fine details of the complex 3 - D structure of the protein.

When they turned up the volume on the signal, using gene therapy techniques to increase the production of the signaling molecule, the mice with CMT regained muscle strength and their ability to walk improved significantly.

«The signal detection for our technique is very similar to what is done with stimulated Raman scattering, except that instead of detecting only the intensity of the light, we detect polarization information that tells us if molecules are highly oriented or totally disorganized.»

If the cell is well supplied with nutrients, this molecule is abundant and signals to the cell that the tank is full.

Researchers from the IceCube project will place a string of Digital Optical Modules into this hole, which can detect the faint signal produced on the rare occasion when a neutrino collides directly with the nucleus of an atom in a molecule of ice.

Loaded with signaling molecules, exosomes spread through the body «like messages in a bottle,» says R. Douglas Fields, a neurobiologist at the National Institutes of Health.

MIXED SIGNALS Minibrains grown in the lab form nerve cells (red) prematurely and show signs of dying cells (green) when treated with a signaling molecule called LIF.

Researchers report that anemonefish rely on a signaling molecule that is almost identical to oxytocin — known as the love hormone in humans and also associated with mothering — to maintain their fatherly fidelity.

The types can be distinguished by the molecules they produce, but scientists haven't had a full picture of how they interact with each other as signals move through the sensory cortex.

They form a pore with a filter that selectively allows the passage of potassium ions, and which is controlled by the signaling molecule cAMP.