Sentences with phrase «signaling pathway activated»

Further research showed that the signaling pathways activated during the worms» response are similar to the pathways activated when more complex animals experience fear.

Various cancer drugs therefore target the signaling pathways activated in the process, some of which have recorded astonishingly positive results in the clinic and are able to prolong the lives of seriously sick patients.

Under further scrutiny, the researchers discovered that the signaling pathways activated during the worm's time of distress are comparable to those pathways activated when other animals exhibit fear.

Quantitative Single - Cell Analysis of Signaling Pathways Activated Immediately Downstream of Histamine Receptor Subtypes.

The first aim of this study is to dissect the signaling pathways activated downstream of TLR2 by CEP in the various cells local to the retina.

Further research showed that the signaling pathways activated during the worms» response are similar to the pathways activated when animals that are more complex experience fear.

Dr. Doyle's laboratory focuses on understanding the initial signaling pathways activated during an inflammatory response.

Not exact matches

Through numerous studies, Szyf has found that common signaling pathways known to lead to cancerous tumors also activate the DNA - methylation machinery; knocking out one of the enzymes in that pathway prevents the tumors from developing.

Previous studies have shown that such vulnerability can lead to more frequent anxiety, and anxiety is known to activate a metabolic pathway responsible for the production of pro-inflammatory cytokines, signaling proteins that include interleukin - 6 (IL - 6).

Biotech company Trevana's drug, oliceridine, acts as a μ - opioid receptor to activate a pain - relieving signaling pathway with less triggering of a separate path that leads to depressed breathing.

The new research, reported Nov. 25 in the Journal of Biological Chemistry, investigated the role of two proteins, GRB10 and p70S6K, in the control of the signaling pathway that activates M2 cells.

«Now that we know the cell of origin for Barrett's esophagus, the next step is to develop therapies that target these cells or the signaling pathways that are activated by acid reflux,» said Dr. Que.

AKR1B1, in turn, elevated Twist2 levels by producing a lipid called prostaglandin F2 that activates the NF - B signaling pathway.

We found that when androgens activated this signaling pathway, it hijacked normal conditions, allowing the tumor to use diverse nutrients to the detriment of the patient,» says Frigo.

Consistent with previous findings, Apc suppression in the animals activated the Wnt signaling pathway, which is known to control cell proliferation, migration, and survival.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

The data included protein expression, protein phosphorylation, which indicates which signaling pathways are activated, and messenger RNA and microRNA expression.

Several years ago, researchers found that 80 percent of patients with uveal melanoma had mutations to GNAQ or GNA11, genes that activate signals in the mitogen - activated protein kinase (MAPK) pathway.

The IU researchers looked at toll receptor 4 (TLR4), which activates two signaling pathways that stimulate the production of more neutrophils during common infections, but suppress it during severe infections.

A cell signal pathway with constitutive activity requires no binding partner (ligand) to activate; instead, the signaling circuit continually activates itself.

Researchers at Boston University School of Medicine (BUSM), under the direction of Sam Thiagalingam, PhD, found that a protein secreted by BLBC cells, called periostin (POSTN), acted to nurture and support cancer stem cells by activating a distinct signaling pathway in these cells.

«When the imprinting block is lifted, the Igf2 - Igf1r signaling pathway is activated,» said Venkatraman.

This supported the notion that ItpkB maintains HSCs quiescence by dampening the major activating signaling pathway mentioned above.

They focused on ItpkB because it is produced in HSCs, and the Sauer lab and others had previously shown that ItpkB controls a major signaling pathway in other cells that had been implicated in activating HSC.

However, c - RAF has also been shown to activate signaling through the mitogen - activated protein kinase (MAPK) pathway.

Protein interactions between niche glial cells and the stem cells activate the Hippo signaling pathway in the stem cells to repress growth and cell division.

Meanwhile, fertilisation of the egg cell activates its «ethylene signalling» pathway, which degrades the nucleus of the persistent synergid cell.

Normally, when the body detects an outside invader such as a virus, a signalling system known as the PKA pathway responds by turning on 99 genes that then activate T - cells to destroy the invader.

When the mitochondrial translation rate increases, the mTOR signaling pathway is activated, which causes the increase in the cytoplasmic protein translation rate to counteract pressure from the increased mitochondrial translation, thus representing a new evolutionary adaptation mechanism.

Like a cascade, after the first molecule in a pathway receives a signal, it activates another molecule and so forth until the cell function is carried out.

«We found a signaling pathway, where SSP phosphorylates the WRKY2 protein in the zygote, thus activating WRKY2,» explains Ueda.

In order to keep step with the «quickened» mitochondrial translation, somatic cells activated the mTOR signaling pathway in order to accelerate cytoplasmic translation and balance mitochondrial translation.

They found that silencing the TOR signalling pathway — activated in many different types of cancer — increased ER stress in the cells.

Janus kinases carry out important intracellular functions in many organs — for instance, activating key signal pathways in the systems which form new blood cells.

This study also found that GATA - 3 regulates the signaling pathway that activates the oncogene c - MYC.

Previously, longevity researchers believed dietary restriction was regulated via an insulin - signaling pathway, where the levels of the nutrient - sensing hormone would fall in response to lowered food intake, activating a DNA - binding protein called daf - 16 that would then confer longevity through the regulation of genes under its control.

«This detection activates cell - signaling pathways that produce antimicrobial peptides, suppress the growth of harmful bacteria, and maintain the integrity of the intestine's epithelial barrier.

Bohn's laboratory has pioneered the concept that KOR signaling can be fine - tuned to preferentially activate certain pathways over others so that the receptor signals through G proteins rather than through a protein called β - arrestin2.

«We have already observed that gene egr - 4 is regulated by the epidermal growth factor receptor (EGFR) signaling pathway, so it will enable to identify also the factors that activate this pathway during anterior regeneration.

When there is nutritional excess, the protein load exceeds the ER folding capacity and a collection of conserved signaling pathways, termed the unfolded protein response (UPR), are activated to preserve ER function.

STAR2 works by specifically binding to a cell surface protein called TNFR2, activating a signaling pathway that increases the number of T reg cells.

Second — and totally unexpected — signalling pathways are activated for this which have always been described as pro-inflammatory,» Vettorazzi summarizes the research results which were recently published in Nature Communication.

Dr. Veenstra joined NCI - Frederick in the fall of 2001 to implement a state - of - the - art mass spectrometry center that focuses on the discovery of signaling pathways and networks that are activated within cells as a response to external perturbations.

It locks onto and deactivates a protein, Smoothened, that activates the Hedgehog signaling pathway, which orchestrates how embryonic stem cells develop.

A metabolic pathway that is up - regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology.

Evan Paull, a graduate student in Stuart's lab at UC Santa Cruz (now at Columbia University), led the computational analyses, which involved integrating the phosphoproteomic data with genomic and gene expression datasets to provide a unified view of the activated signaling pathways in late stage prostate cancer.

The FOP mutant ACVR1 receptor (c. 617A; R206H) activates BMP - independent signaling of the BMP pathway.

Independently of Smads, BMP signaling also activates the p38 MAPK pathway (32 — 34); however, additional assays in COS - 7 cells showed no increase in p38 MAPK phosphorylation in response to ACVR1 (R206H)(data not shown).

These data indicate that although the ACVR1 R206H mutant remains responsive to BMP ligand, this mutation does not require BMP ligand in order to activate BMP pathway signaling and ID1 gene transcription.

It has been known for a number of years that PREX2 is a GTP / GDP exchange factor that inhibits a tumor suppressor protein called PTEN, and that this process can promote tumorigenesis by activating the PI3K signaling pathway (Fine et al., 2009; Hodakoski et al., 2014; Figure 1A).