Sentences with phrase «signaling pathway by»

Insulin and leptin receptor resistance from too many net carbs and activation of the mTOR metabolic signaling pathway by too much protein.

«Systemically and chronically blocking IKK2 activity is too toxic to be used in chemotherapy, but we might be able to target another molecule in the signaling pathway by which IKK2 regulates tumor growth.»

Up - Regulation of PKR Signaling Pathway by Ethanol Displays an Age of Onset - Dependent Relationship.

The inhibition of this signaling pathway by NT219 protected worms from toxic protein aggregation that in humans is associated with the development of Alzheimer's or Huntington's disease.

His research has also discovered a novel mechanism to regulate neurotrophic growth factor - associated signaling pathways by miRNAs in context of PD and Alzheimer's disease (AD), and a role of dysfunctional bioenergetics in the pathogenesis of late - onset AD.

Modulation of apoptosis and immune signaling pathways by the Hantaan virus nucleocapsid protein.

The mature ISGF3 complex serves as a transcriptional regulator in type I IFN signaling pathways by translocating into the nucleus and then binding to ISRE of certain ISGs.

Not exact matches

A Canadian study published this year around the same time titled «Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways» observed that coconut oil and its medium chain fatty acids (MCFAs) protect against amyloid beta (Aβ) induced neurotoxicity in primary rat cortical neurons.

The critical immune pathway in question is the NOD2 pathway, which detects and responds to bacterial invaders by releasing inflammatory signals to fight the infection.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researchers.

By using a combination of advanced genetics, molecular approaches, and microscopy techniques, they found that this signaling pathway is used in the adult brain in a completely novel way.

Targeting stromal cells as well as the cancer cells blocks multiple cell signalling pathways that are used by cancer cells to become aggressive.

The transcription of non-coding regions in the genome is precisely regulated by cellular signaling pathways — and on a grand scale: up to 80 per cent of the RNA copies were non-coding.

«Now that we know the cell of origin for Barrett's esophagus, the next step is to develop therapies that target these cells or the signaling pathways that are activated by acid reflux,» said Dr. Que.

Specifically, I am investigating how the cAMP / PKA signaling pathway affects collagen structure and deposition, using a hydrogel - based, three - dimensional culture system to create a model that is more physiologically relevant than one produced by standard two - dimensional tissue culture methods.

Researchers from the «Angiogenesis signaling pathways» research group of the Institute of Biomedical Investigation of Bellvitge (IDIBELL), led by Dr. Mariona Graupera, have unveiled the potential therapeutic benefit of a selective inhibitior of the PI3 - kinase (PI3K) protein in pancreatic neuroendocrine tumors (PanNETs).

AKR1B1, in turn, elevated Twist2 levels by producing a lipid called prostaglandin F2 that activates the NF - B signaling pathway.

In the vernacular of the science, calorie restriction appears to increase life span and health span at least in part by «reducing signaling in the insulin / IGF pathway.»

Some cancer drugs stop tumours by blocking the signalling pathway that allows the tumour to grow, effectively placing a lock on a protein «door».

«We discovered that three particular proteins involved in the Wnt signaling pathway aren't just involved in the development of severe illnesses, but also in the qualitative refinement of highly developed tissue,» says co-first author Claudio Cantù from the molecular biologist research group lead by Prof. Konrad Basler.

Research led by Margery Smelkinson found that NS1 modulates the activitiy of a signaling cascade known as the Hedgehog pathway (so named because fruit fly larvae lacking the Hedgehog gene emerge hairless and resemble tiny hedgehogs).

Previous research by Lee's lab had shown that p75 is involved in a signaling pathway that regulates the development of sensory neurons — cells which transmit our sensation of pain, touch and muscle tension — in the dorsal root ganglia.

However, little is known about the specific growth - signaling pathways affected by DNA methyltransferase enzymes like DNMT3B.

If plastic harms, it does so by stealth: by mimicking our own hormones, by scrambling signals during development, by stimulating our own pathways excessively.

Work spearheaded by professor Vicent Arbona is progressing in the understanding of the signaling pathway of a plant hormone that will make plants more resistant to stress by flooding.

A fourth study finds that a generalized seizure leads to diminished short and long - term memory by interfering with key signaling pathways in the brain.

By understanding the genes and pathways involved in the immune response, we may be able to interpret the signals that determine whether an organism decides it is beyond repair or tries to regenerate.

Researchers at Boston University School of Medicine (BUSM), under the direction of Sam Thiagalingam, PhD, found that a protein secreted by BLBC cells, called periostin (POSTN), acted to nurture and support cancer stem cells by activating a distinct signaling pathway in these cells.

Gamma secretase inhibitors tend to produce adverse effects by interacting with Notch, an important pathway for cellular signaling.

Taken together, the findings demonstrate that the GRN mutation causes the defect in cortical neuron formation by altering the Wnt signaling pathway.

By using pharmacological small molecule inhibitors as well as neutrophils from genetically modified mouse strains the team could identify essential receptor and signaling pathways involved in the nicotine - mediated activation of neutrophils.

This supported the notion that ItpkB maintains HSCs quiescence by dampening the major activating signaling pathway mentioned above.

Tatar's research, along with simultaneous independent work by Linda Partridge of University College London, U.K., and her colleagues, demonstrated that an insulin - like signaling pathway controls diapause and aging in flies — similar to what had already been found in the roundworm Caenorhabiditis elegans (see «Growing Old Together»).

By analyzing skin cells from achromatopsia patients and their unaffected family members, the researchers confirmed that the ATF6 mutations were interfering with the signaling pathway that regulates the unfolded protein response.

While the VEGF treatment escape pathway is known to be induced and sensitized by PDT, the research team found that PDT also induces signaling via the MET pathway.

Plants perform these regulations mainly by regulating nuclear gene expression and multiple intracellular signaling pathways have been shown to play a role in the genomic response of plants to stress, but the processes are not well understood.

The discoveries achieved during this project, which was funded by the Rosetrees Trust of Britain, were published this week in the journal Aging Cell («A novel inhibitor of the insulin / IGF signaling pathway protects from age - onset, neurodegeneration - linked proteotoxicity»).

To help identify genes and signaling pathways that may be influenced by zinc, Knoell and his team performed a genome - wide microarray analysis of lung tissue taken from zinc - deficient mice with sepsis.

Knockdown of LL34 expression leads to decreased retinoic acid signaling, suggesting that this lncRNA may play an early role in the development of the lung, as well as other tissues controlled by this pathway.

Biologists at Johannes Gutenberg University Mainz (JGU) have now discovered that the phases of quiescence in the Drosophila fruit fly central nervous system are controlled by the Hippo signaling pathway.

(Quadrupling Muscle Mass in Mice by Targeting TGF - Signaling Pathways PLoS One)

«We have discovered the key role played by the TOR signalling pathway in driving the expansion of the endoplasmic reticulum, and sending a cell's factories into overdrive.

Normally, when the body detects an outside invader such as a virus, a signalling system known as the PKA pathway responds by turning on 99 genes that then activate T - cells to destroy the invader.

Drugs tested by the U-M appear to correct the signaling pathway that is disrupted in muscular dystrophy at an earlier step than the phosphodiesterase inhibitors.

By finding out which signals and genes are the targets, we now have new targets that will allow us to attack this pathway.»

Al Alam, who is also assistant professor at Keck School of Medicine of the University of Southern California, added that the exact mechanism by which the protein and signaling pathway interact still require further investigation.

«Almost nothing is known» about the molecular and cellular mechanism by which water is detected in the mouth and throat, and the neural pathway by which that signal is transmitted to the brain, says Zachary Knight, a neuroscientist at the University of California, San Francisco.

In their most recent study, the researchers confirmed receptor BAI3's essential role by blocking its interaction with the DOCK signalling pathway.

The PKCƐ signal pathway, which is used by cancer cells but rarely by normal cells, could be important in targeting some cancer cells as they rely on this pathway to survive.

Developed by researchers in the UK and Germany and published in Nature Methods, OmniPath offers a comprehensive, unified collection of literature - curated signalling pathways based on an analysis of 41,000 scientific papers.