Sentences with phrase «signaling pathway from»

INDRA is used to build models of p53 dynamics, resistance to targeted inhibitors of BRAF in melanoma, and the Ras signaling pathway from natural language.

This landmark revelation was the first definition of an entire cellular signaling pathway from the cell surface to the nucleus, providing an important paradigm for understanding intracellular signaling.

To prevent this from happening patients are treated with a second compound that stops this cell signaling pathway from being unintentionally activated.

To better coordinate bacteria, bioengineers Lingchong You and Frances Arnold of the California Institute of Technology and colleagues rewired a natural cell - signaling pathway from Vibrio fisheri, bacteria in the light organ of deep - sea squid.

«What is really amazing about this work is that it demonstrates that a pure signalling pathway from a neuronal system can control a developmental switch — the one that tells a larva to become a pupa,» says Siddharth Jayakumar, Hasan's student and the lead author of the paper that details these findings in the journal eLife.

Not exact matches

A Canadian study published this year around the same time titled «Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways» observed that coconut oil and its medium chain fatty acids (MCFAs) protect against amyloid beta (Aβ) induced neurotoxicity in primary rat cortical neurons.

«We then conducted a series of supplementary experiments to identify a probable signal pathway, from the occurrence of the genetic risk variant to clinical symptoms in the form of psychosis and cognitive impairment,» says Professor Landén.

Aside from helping to better design PD - 1 blockade treatments, Wherry's findings have also helped to identify potential biomarkers in the PD - 1 signaling pathway.

Through numerous studies, Szyf has found that common signaling pathways known to lead to cancerous tumors also activate the DNA - methylation machinery; knocking out one of the enzymes in that pathway prevents the tumors from developing.

«The pathway mainly involves signalling via the brains» immune cells, and thus differs from how today's drugs operate.

The researchers from Halle have now figured out that the already familiar MAP kinase signalling pathway plays a central role.

«We have identified two components of the knee joint that control bone growth, at least following injury, and we've shown that signals from these components influence distinct growth plate signaling pathways and lead to reduced bone growth,» concludes Alexandra Joyner, PhD, senior author and Developmental Biologist at Sloan Kettering.

Researchers from the «Angiogenesis signaling pathways» research group of the Institute of Biomedical Investigation of Bellvitge (IDIBELL), led by Dr. Mariona Graupera, have unveiled the potential therapeutic benefit of a selective inhibitior of the PI3 - kinase (PI3K) protein in pancreatic neuroendocrine tumors (PanNETs).

«We discovered that three particular proteins involved in the Wnt signaling pathway aren't just involved in the development of severe illnesses, but also in the qualitative refinement of highly developed tissue,» says co-first author Claudio Cantù from the molecular biologist research group lead by Prof. Konrad Basler.

What was especially «exciting» about this finding, he says, is that these variations were near a neural highway that previous studies have shown helps regulate life span in worms and flies, and that stopping chemical signals from this brain pathway extends the life span of mice.

Researchers at CNRS, CEA and Université d'Aix - Marseille have demonstrated that an ancient signaling pathway inherited from bacteria impacts plant growth and development.

Scaffold proteins offer a simple, flexible strategy for regulating selectivity in pathways, shaping output behaviors, and achieving new responses from preexisting signaling components.

To unravel the complex signaling pathway map, the scientists used their own findings from the analysis of factors regulated up or down in the interplay between tissue and stem cells, linking them with the signaling pathways described in existing literature.

By using pharmacological small molecule inhibitors as well as neutrophils from genetically modified mouse strains the team could identify essential receptor and signaling pathways involved in the nicotine - mediated activation of neutrophils.

By analyzing skin cells from achromatopsia patients and their unaffected family members, the researchers confirmed that the ATF6 mutations were interfering with the signaling pathway that regulates the unfolded protein response.

The inhibition of this signaling pathway by NT219 protected worms from toxic protein aggregation that in humans is associated with the development of Alzheimer's or Huntington's disease.

The discoveries achieved during this project, which was funded by the Rosetrees Trust of Britain, were published this week in the journal Aging Cell («A novel inhibitor of the insulin / IGF signaling pathway protects from age - onset, neurodegeneration - linked proteotoxicity»).

To help identify genes and signaling pathways that may be influenced by zinc, Knoell and his team performed a genome - wide microarray analysis of lung tissue taken from zinc - deficient mice with sepsis.

When the mitochondrial translation rate increases, the mTOR signaling pathway is activated, which causes the increase in the cytoplasmic protein translation rate to counteract pressure from the increased mitochondrial translation, thus representing a new evolutionary adaptation mechanism.

At the University Children's Hospital Zurich, researchers from the University of Zurich have identified a signaling pathway in liver cells that may contribute to the development of steatosis.

«For example, mouse mammary tumors shared a signaling pathway that is found in human lung cancer and controls how cells reproduce and move from one location to another.»

«We reasoned that perhaps we could disentangle the signaling pathways that produced the desirable consequences from the undesirable consequences,» McNamara said.

We conclude that juvenile hormone deficiency, which results from InR signal pathway mutation, is sufficient to extend life - span, and that in flies, insulin - like ligands nonautonomously mediate aging through retardation of growth or activation of specific endocrine tissue.

«Despite originating from the same physical events, visual and auditory information are processed in largely independent neural pathways, and yet, with no apparent effort, we can instantly tell which signals belong together.

«We found that the well - known Notch protein is responsible for keeping blood vessels from becoming leaky, and does so through a secondary signaling pathway that operates in a completely different manner than its known transcription - based pathway,» says Chris Chen, M.D., Ph.D., Associate Faculty member of the Wyss Institute and Professor of Biomedical Engineering at Boston University, who is the corresponding author of the paper.

In a resignation letter to the research community, Varmus decried the harsh budget climate he has faced and pointed to a list of accomplishments, from creating an NCI center for global health to launching a project to find drugs targeting RAS, an important cell signaling pathway in cancer.

The Wnt / β - catenin signaling pathway and microRNA 335 are instrumental in helping form differentiated progenitor cells from stem cells.

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

«Signaling pathway helps protect healthy tissue from overly active immune responses.»

The team then detailed the signaling in this pathway, from cold - induced norepinephrine release, to upregulation of GADD45γ in brown fat cells, to the activation of ERRβ and another closely related protein, ERRγ, which turned out to be also prevalent in brown fat cells and relevant to thermogenesis.

Drugs that tweak these nutritional signaling pathways could one day keep diabetics from overloading their blood with sugar, Puigserver says.

Dr. Augustinaite studies the visual pathway, where signals from the retina are sent to the visual cortex, where the brain interprets signals from the eye.

Nearly 20 percent of children with NF1 develop brain tumors that involve the optic pathway, affecting the nerves that carry vision - related signals from the eye to the brain.

With the knowledge that fibrosis appears to radiate from blood vessels, Humphreys and colleagues examined the hedgehog signaling pathway, which normally regulates organ development but whose roles in the adult are less clear.

However, chondrogenesis assays in chick micromass cultures showed that enhanced signaling by the mutant R206H ACVR1 can be partially inhibited by the BMP antagonist Noggin, suggesting that in addition to BMP - independent activity by the R206H ACVR1 receptor, this mutant receptor is also responsive to BMP, consistent with previous BMP signaling pathway studies that used cells derived from FOP patients (48 — 50).

In this study scientists used cells from the fruit fly Drosophila to screen for small molecules that suppress the signalling pathway central to the development of MPNs in humans.

We are investigating the genes that are the target of this pathway, how it influences the cells of growing worms, the size differences between the sexes (hermaphrodite worms are larger than males), and the way in which it mediates signals from the environment.

The scientists then looked at gene activation in insulin signaling pathways for iPSCs and fibroblasts with IR mutations, and for corresponding cells derived from people without those mutations.

Interestingly, a previous STEM CELLS study from Janeczek et al. [3] established that activating the WNT signaling «pathway in BM led to the generation of an osteogenically enhanced subset of stem cells.

Opioids work to activate this pathway via the mu receptor, and decrease the signal coming in from the painful site.

A new study describes an improved protocol for the efficient differentiation of endothelial cells from pluripotent stem cell sources and highlights the importance of the MAPK and PI3K signaling pathways

In this representation, signal is coming from signalling pathways (upper part of the figure), where signalling receptors binding a ligand transmit their signal to enzymes and transcription factors.

The gatekeeper (OLM - alpha2; red) counteract signaling coming from the TA pathway (blue), thereby allowing local inputs from the SC pathway (green) on the pyramidal cell (orange) to become stronger.

Apart from mere binding studies, the function of the signaling pathway could be traced in detail with switchSENSE ®.

Studies have shown that exposure of tumor cells to therapeutic doses of radiation activates cell survival signaling pathways such as EGFR - RAS [2 - 5] and its downstream molecules such as ERK1 / 2, PI3K - AKT, JNK, etc. apart from several other signaling molecules [4, 6, 7].