Sentences with phrase «signaling pathways control»

Her research focuses on understanding how signaling pathways control gene expression, using T cells and other cells of the immune system as models.

Abstract Our team is interested on how signaling pathways control of adult skeletal muscle plasticity.

Tatar's research, along with simultaneous independent work by Linda Partridge of University College London, U.K., and her colleagues, demonstrated that an insulin - like signaling pathway controls diapause and aging in flies — similar to what had already been found in the roundworm Caenorhabiditis elegans (see «Growing Old Together»).

We are particularly interested in how several molecular signalling pathways control the size to which the worm grows (about 1 mm long).

The FLT3 - signaling pathway controls cell proliferation and survival, particularly of hematopoietic progenitor cells.

Aulicino F, Theka I, Ombrato L, * Lluis F, * Cosma MP (2014) Temporal perturbation of the Wnt signalling pathway controls cell reprogramming via Tcf1 activity.

Not exact matches

The Serhan lab, which focuses on identifying and elucidating the structures of bioactive molecules, has made critical discoveries over the last two decades that have illuminated the biochemical signaling pathways that resolve and control inflammation and pain associated with disease and injury recovery.

The AXIN2 protein interacts with proteins in the Wnt signalling pathway, which is involved in controlling many cellular processes, including development.

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a signaling pathway in cancer cells that controls their ability to invade nearby tissues in a finely orchestrated manner.

«What is really amazing about this work is that it demonstrates that a pure signalling pathway from a neuronal system can control a developmental switch — the one that tells a larva to become a pupa,» says Siddharth Jayakumar, Hasan's student and the lead author of the paper that details these findings in the journal eLife.

The new research, reported Nov. 25 in the Journal of Biological Chemistry, investigated the role of two proteins, GRB10 and p70S6K, in the control of the signaling pathway that activates M2 cells.

«We have identified two components of the knee joint that control bone growth, at least following injury, and we've shown that signals from these components influence distinct growth plate signaling pathways and lead to reduced bone growth,» concludes Alexandra Joyner, PhD, senior author and Developmental Biologist at Sloan Kettering.

Geneticists at Martin Luther University Halle - Wittenberg (MLU) have deciphered a central signalling pathway that encodes and controls these processes.

Consistent with previous findings, Apc suppression in the animals activated the Wnt signaling pathway, which is known to control cell proliferation, migration, and survival.

They were interested in one of the cell's key signaling pathways, the MAPK pathway, which helps control cell growth, embryonic development, and the maturation of oocytes into eggs.

The team's next step is to zoom in on the molecular mechanisms that control how the Wnt signaling pathway interacts with the nail stem cells to influence bone and nail growth.

Still unclear is how the methuselah gene mutation makes flies more stress - resistant, but the amino acid sequence of the protein it makes may be part of a signaling pathway that controls how well cells resist or repair these stresses.

«It turns out that the same signal — the so - called epidermal growth factor (EGF) pathway — control both the formation of pipes and beta cells through polarity changes.

Scientists study the germline of the roundworm Caenorhabditis elegans to identify the mechanisms that control stem cell proliferation and homeostasis, as well as to advance our molecular understanding of homologous signaling pathways humans.

They focused on ItpkB because it is produced in HSCs, and the Sauer lab and others had previously shown that ItpkB controls a major signaling pathway in other cells that had been implicated in activating HSC.

A related study, also published in PLOS Genetics, shows that RPM - 1 functions as a part of a novel pathway to control β - catenin activity — this is the first evidence that RPM - 1 works in connection with extracellular signals, such as a family of protein growth factors known as Wnts, and is part of larger signaling networks that regulate development.

More importantly, Choudhury and colleagues found that DAZAP1 directly links the regulation of gene splicing with the MAP kinase pathway — a key signaling pathway that controls cell proliferation.

Knockdown of LL34 expression leads to decreased retinoic acid signaling, suggesting that this lncRNA may play an early role in the development of the lung, as well as other tissues controlled by this pathway.

This study reveals how lipids control SH2 domain - mediated cellular protein interaction networks and suggests a new strategy for the therapeutic modulation of pY - signaling pathways.

Biologists at Johannes Gutenberg University Mainz (JGU) have now discovered that the phases of quiescence in the Drosophila fruit fly central nervous system are controlled by the Hippo signaling pathway.

A protein in the TOR signalling pathway, called SREBP, controls the flow of messages to the endoplasmic reticulum telling it to expand — and could allow cancer cells to produce enough proteins and lipids to fuel their non-stop growth.

A signaling pathway is a group of molecules in a cell that work together to control one or more cell functions.

«This might mean that strategies to control exosome release could be used to interrupt the ephrin - Eph signaling pathway and thereby disrupt tumour growth,» he surmises.

Named after the BMP signal protein, this pathway controls the evolution of various cell types depending on the protein concentration, similar to the Wnt pathway, but in a different direction.

Previously, longevity researchers believed dietary restriction was regulated via an insulin - signaling pathway, where the levels of the nutrient - sensing hormone would fall in response to lowered food intake, activating a DNA - binding protein called daf - 16 that would then confer longevity through the regulation of genes under its control.

«For example, mouse mammary tumors shared a signaling pathway that is found in human lung cancer and controls how cells reproduce and move from one location to another.»

The research team also found that expression of genes that control glucose metabolism and insulin signaling pathways were higher in rats that consumed sufficient amounts of vitamin A.

A critical part of that balance involves the control of a signaling pathway that relies on NF - kappaB, a protein necessary for the survival and function of neurons.

Jasper says TOR can be regulated by a number of stimuli, and researchers are now attempting to better understand how the activity of this signaling pathway is controlled in stem cells.

This tells researchers which genes or signaling pathways are controlled by TAZ / YAP.

We therefore believe that a targeted inhibition of this specific signalling pathway, which controls how the cells in the vessel walls are connected, might work better as a cancer therapy than the more general VEGFA inhibition that is used today,» says Lena Claesson - Welsh.

Major studies how cancer cells hijack specific signaling pathways to spread throughout the body, using drugs and genetic manipulation to probe the inner workings of these out - of - control cells.

Computational biology; use of control and information theory to study signal transduction pathways.

In recent decades, scientists have identified genes, enzymes, metabolic pathways and signaling molecules that control those activities.

The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity.

Signaling pathways involve molecules in a cell that control cell functions — like cell division — by cooperation.

Cells rely on these pathways to respond appropriately to their environment (so that the right growth - controlling genes get turned on in response to a growth signal)-- but disruptions in signaling pathways can have dire consequences.

Protein systems, such as Ras, make up the complex signaling pathways that control whether a cell divides or, in some cases, becomes cancerous and metastasizes into other regions of the body.

A presynaptic endosomal trafficking pathway controls synaptic growth signaling.

Researchers investigating signaling pathways which control pluripotency highlight newly found interactions and redundancies in mouse embryonic stem cells

Cutting edge: CD28 - mediated transcriptional and posttranscriptional regulation of IL - 2 expression are controlled through different signaling pathways.

Her goals are to continue working to understand how the dynamics of p53 and other signaling pathways important in cancer control cell fate decisions.

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

We have identified several molecular targets such as Bcl - xL, Bcl - 2, and survivin, along with upstream signaling intermediates such as PI -3-kinase, Akt, and the canonical and non-canonical NF - κB pathways that control the activities of OX40.

Endowed with the power to control the activity of other genes, GTF2I might regulate signal pathways determining the structure and function of the brain or the production of neurohormones such as vasopressin and oxytoxin.