Sentences with phrase «signaling pathways in»

, Anti-inflammatory effects of aromatic turmerone through blocking of NF - κB, JNK, and p38 MAPK signaling pathways in amyloid β - stimulated microglia, 2012

Involvement of PI3K / PKG / ERK1 / 2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl - L - carnitine and alpha - lipoic acid against HNE - mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.

The discovery that CN2097 can reinstate BDNF - signaling pathways in AS mice to facilitate LTP suggests that the development of drugs targeting PSD - 95 may be beneficial in treating the behavioral deficits in AS.

Finally, the strategy applied here for selective delivery of MK801 can be extended to other small molecules for use in brain tissue (Tian et al., 2012), allowing for an approach that combines chemistry, molecular genetics, and neurobiology to dissect cell signaling pathways in specific cell types in the central nervous system.

Webinar: View our webinar on TLR Signaling Pathways in Immunity and Beyond on YouTube and download the slides from the TLR webinar.

For example, studies of cell signaling pathways in normal cells and cancer cells have contributed greatly to our knowledge about the disease, revealing molecular alterations that are shared among different types of cancer and pointing to possible strategies for treatment.

De novo mutations in inhibitors of Wnt, BMP, and Ras / ERK signaling pathways in non-syndromic midline craniosynostosis.

Dr. Rebecca Vega Thurber received her doctorate in 2005 from Stanford University where she studied developmental cell signaling pathways in sea urchin larvae.

Titles: 1) Angiopoietin - Like 4 Confers Resistance to Hypoxia / Serum Deprivation - Induced Apoptosis through PI3K / Akt and ERK1 / 2 Signaling Pathways in Mesenchymal Stem Cells

Angiopoietin - Like 4 Confers Resistance to Hypoxia / Serum Deprivation - Induced Apoptosis through PI3K / Akt and ERK1 / 2 Signaling Pathways in Mesenchymal Stem Cells

The effect of a novel antagonist of growth hormone releasing hormone on cell proliferation and on the key cell signaling pathways in nine different breast cancer cell lines.

In addition to his role at Chicago Center for Health Equity Research, Robert Winn is the primary investigator in a lab at the University of Illinois at Chicago that explores signaling pathways in lung cancer.

There is also growing evidence that the protein - coding repertoire of the innate immune system is rapidly evolving in insects [5], [8]--[11], even though comparative genomic analysis reveals the existence of a conserved core of immune signaling pathways in most insects [12]--[15].

In this study we have shown that a bacterial toxin perturbs signaling pathways in ILC3s, down - modulating the innate immune response.

By probing the biology of B. anthracis lethal toxin we have identified MEK1 / 2 - ERK 1/2 and MKK3 / 6 - p 38 as important signaling pathways in the production of IL - 22 in ILC3s.

We show that subpopulations of human astrocytes, generated by activation of different signaling pathways in the same population of human glial precursor cells, have markedly different effects when transplanted into the injured spinal cord.

Experimental inhibition of MEK signaling pathways in ILC3s likewise resulted in reduced IL - 22 production.

Bacterial toxins are valuable molecular tools for elucidating signaling pathways in cells [53].

We have used B. anthracis to study the effect of MAPK signaling pathways in group 3 innate immune lymphocytes (ILC3s).

Cross-talk between Phosphate Starvation and Other Environmental Stress Signaling Pathways in Plants

Ionizing radiation has been shown to activate these signaling pathways in different intensities and in a cell type - dependent manner [6].

Crucial for all these processes is the correct operation of signaling pathways in cells and tissues.

The discovery eventually led to the uncovering by others of two additional signaling pathways in mammalian cells that, together with Ire1, help maintain equilibrium in the face of stress, averting a host of diseases.

His team uncovered a genetic element known as a silencer that plays a crucial role in shaping the molecular identity of CD4 cells, as well as the immunological signaling pathways in which CD4 and CD8 molecules participate along with the T cell antigen receptor.

Tobias Heckel (Hoflack, TUD)-- «Revealing Src tyrosine kinase - dependent signaling pathways in osteoclasts: Implications on actin organization and cell polarity» (2008)

Anne Meyer (Reichmann, TUD)-- «Intracellular signaling pathways in the dopaminergic specification of fetal mesencephalic neural stem cells» (2009)

B signaling pathways in osteoprotegerin knockout mice.

«Analysis of metastatic prostate cancers suggests treatment options: Study maps out abnormal signaling pathways in prostate cancer cells and provides computational approaches to identify individualized targets for therapy.»

Evan Paull, a graduate student in Stuart's lab at UC Santa Cruz (now at Columbia University), led the computational analyses, which involved integrating the phosphoproteomic data with genomic and gene expression datasets to provide a unified view of the activated signaling pathways in late stage prostate cancer.

Moreover, these sex - specific behavioral differences are accompanied by sex differences in molecular signaling pathways in the striatum brain region.

And the one with «significant flaws» was the Alliance for Cell Signaling, which set out to map cell - signaling pathways in heart muscle cells and immune cells.

«In addition to known disease - related genes, we have discovered seven novel genes as the cause of X-linked intellectual disability and analysed what signaling pathways in the cells each protein is involved in,» says Kalscheuer.

The CUMC team is currently using the new mouse model to study signaling pathways in the brain that drive anorexic behavior, with the ultimate goal of identifying therapeutic targets.

«And this model not only shows us the most important factors that contribute to the onset of anorexia, it's also helping us to identify signaling pathways in the brain that ultimately drive this potentially fatal eating disorder.»

This webinar will focus on how rewiring of signaling pathways in response to drug treatment contributes to resistance and how this knowledge can be leveraged to develop more effective treatment strategies.

Imaging flow cytometry (IFC) has emerged as a useful and efficient tool for studying the signaling pathways in immunophenotypically defined subpopulations of immune cells.

A fourth study finds that a generalized seizure leads to diminished short and long - term memory by interfering with key signaling pathways in the brain.

The group is now pursuing studies that couple the mechanical forces of a blast, or pressure wave, to the activation of chemical - signaling pathways in neural cells.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

Therefore, we questioned whether PTPRF gene expression might be elevated in Mature Group 2 samples, as PTPRF overexpression could be causing excessive downward modulation of the insulin signaling pathway in the women with lower insulin sensitivity.

It was deep in the TGF — beta signaling pathway in a gene involved with uvula development.

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a signaling pathway in cancer cells that controls their ability to invade nearby tissues in a finely orchestrated manner.

The physiological role of the auxin signal pathway in the call membrane in contrast had been largely unknown.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

Here we implicate a common signaling pathway in mediating these effects.

«When we blocked the Wnt - signaling pathway in mice with amputated fingertips, the nail and bone did not grow back as they normally would,» says Dr. Ito.

The FGF21 - induced thirst response appears to depend on another signaling pathway in the hypothalmus, the?

Researchers at Boston University School of Medicine (BUSM), under the direction of Sam Thiagalingam, PhD, found that a protein secreted by BLBC cells, called periostin (POSTN), acted to nurture and support cancer stem cells by activating a distinct signaling pathway in these cells.

She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.

They focused on ItpkB because it is produced in HSCs, and the Sauer lab and others had previously shown that ItpkB controls a major signaling pathway in other cells that had been implicated in activating HSC.