Sentences with phrase «signaling pathways involved»

Studies on the effects of GHRH antagonists on prostate and lung cancers demonstrated their ability to modulate signaling pathways involved in cellular proliferation, survival, metastasis, and apoptosis.

Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.

To bypass the disruptive effects of the age - related accumulation of senescent cells, some investigators are working on possible ways to manipulate the signaling pathways involved in enforcing the senescent phenotype.

These rhythms can also affect signaling pathways involved in medication toxicity.

Their experiments provide clues about the neural circuits and signaling pathways involved in compulsive behavior and may provide a useful animal model for studying OCD and evaluating treatments.

The team demonstrated that GPR158 affects key signaling pathways involved in mood regulation in the region of the brain called prefrontal cortex, though the researchers emphasized that the exact mechanisms remain to be established.

By using pharmacological small molecule inhibitors as well as neutrophils from genetically modified mouse strains the team could identify essential receptor and signaling pathways involved in the nicotine - mediated activation of neutrophils.

One factor keeping cells in this immature state is the PTEN gene, which suppresses a signalling pathway involved in cell growth.

The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility.

Previous experiments have enabled them to decode a signalling pathway involved in adipose cell maturation and to show that calories in the nutrient medium influence this process.

Jagged1 plays a key role in a cell signaling pathway involved in many body systems, but it was not previously known to affect Duchenne muscular dystrophy.

Researchers aiming to understand why autism spectrum disorders (ASD) are more common in boys have discovered differences in a brain signaling pathway involved in reward learning and motivation that make male mice more vulnerable to an autism - causing genetic glitch.

«But we have to further study the functions of this histone, identify the other proteins with which it is associated, and determine the enzymes that modify it and why and the cell signalling pathways involved,» explain the scientists.

Signaling pathways involve molecules in a cell that control cell functions — like cell division — by cooperation.

This screening model was validated during our collaboration with the pharmaceutical group Roche and had revealed key signalling pathways involved in the control of NSC self - renewal (see Georges et al., 2015).

But trying to understand the nerve signalling pathways involved is a gargantuan task, given the complexity of the human nervous system, with its billions of neurons and trillions of connections between them.

Not exact matches

Researchers believed that galeterone could be effective against CRPC because it disrupts the androgen receptor signalling pathways that are involved in the cancer, and preclinical work has shown it is active against the AR - V7 variant.

In complex wound management, we think a lot about what the signaling pathways are and what factors can be involved and what kind of things we could do to improve things.

Once there, the protein acts on the osteoblasts and inhibits Wnt activity, which is a cellular signalling pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.

The AXIN2 protein interacts with proteins in the Wnt signalling pathway, which is involved in controlling many cellular processes, including development.

It was deep in the TGF — beta signaling pathway in a gene involved with uvula development.

My postdoctoral work involved signal transduction pathways that regulate chemotaxis.

«The pathway mainly involves signalling via the brains» immune cells, and thus differs from how today's drugs operate.

The study also found that some of the morphing genes in the python's intestine, notably those in a signaling pathway called WNT, were genes that were involved in intestinal and other cancers.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

«We discovered that three particular proteins involved in the Wnt signaling pathway aren't just involved in the development of severe illnesses, but also in the qualitative refinement of highly developed tissue,» says co-first author Claudio Cantù from the molecular biologist research group lead by Prof. Konrad Basler.

Previous research by Lee's lab had shown that p75 is involved in a signaling pathway that regulates the development of sensory neurons — cells which transmit our sensation of pain, touch and muscle tension — in the dorsal root ganglia.

By understanding the genes and pathways involved in the immune response, we may be able to interpret the signals that determine whether an organism decides it is beyond repair or tries to regenerate.

The team also identified genes that had not been previously linked to ASD, but are heavily involved in numerous protein interactions and signaling pathways.

They also investigated if the genes were involved in any known signaling pathways.

The mutations inhibited key molecules involved in insulin signaling (IIS) and the nutrient signaling pathway Target of Rapamycin (TOR).

Their findings may turn out to be important when it comes to research into cerebral cancer, since it is known that components of the Hippo signaling pathway, such as neurofibromin 2, are involved in the generation of brain tumors.

«In addition to known disease - related genes, we have discovered seven novel genes as the cause of X-linked intellectual disability and analysed what signaling pathways in the cells each protein is involved in,» says Kalscheuer.

A critical part of that balance involves the control of a signaling pathway that relies on NF - kappaB, a protein necessary for the survival and function of neurons.

«The mineral zinc acts as a catalytic, structural and signaling factor in the regulation of a diverse array of cellular pathways involving hundreds of enzymes and proteins,» he said.

The scientists administered butein to the mice to block the signalling pathway, which is involved in the body's inflammatory immune responses.

Poznansky's team — with lead scientist Huabiao Chen, PhD, corresponding author of the current report — had been investigating applications of AMD3100, a drug that blocks the CXCR4 / CXCR12 signaling pathway known to be involved in cancer development and in the way in which mesothelioma evades the immune system.

Astonishingly, sphingosine -1-phosphate is only released in the macrophages if — alongside with the binding of dimer - GR to the DNA — a pro-inflammatory signalling pathway is stimulated involving protein kinases p38 and MSK1.

Another surprising finding was the direct link between Notch and genes involved in other B cell signaling pathways.

However, her research group has not yet identified how to make stem cells yield entirely dI1 or entirely dI3 cells — perhaps because another signaling pathway is involved, she said.

Nearly 20 percent of children with NF1 develop brain tumors that involve the optic pathway, affecting the nerves that carry vision - related signals from the eye to the brain.

The mutation affects a receptor for a signaling molecule called netrin that is involved in one of the best - studied pathways in developmental neuroscience, she says, but all of that work has been done in animals such as mice, worms, and fruit flies.

Evan Paull, a graduate student in Stuart's lab at UC Santa Cruz (now at Columbia University), led the computational analyses, which involved integrating the phosphoproteomic data with genomic and gene expression datasets to provide a unified view of the activated signaling pathways in late stage prostate cancer.

The effects of mutations and other genetic changes in cancer cells play out in the complex networks of molecular interactions or «signaling pathways» involved in cell growth, proliferation, and other hallmarks of cancer biology.

«The specific mutation that we have studied allowed us to examine one of the signalling pathways in which VEGFA is involved.

The arabinogalactan sugar chain is commonly present in the cell wall of plants and is known to be involved in various signaling pathways within the cell.

«I believe that the result of this collaboration not only sheds light on the long sought mystery of arabinogalactan sugar chains but will also advance the understanding of the yet to be resolved signaling pathway between cells involving sugar chains.»

Emerging evidence shows that alterations in multiple signaling pathways are involved in primary and / or secondary resistance to checkpoint inhibition.

Moreover, large - scale screens in the C. elegans DMD model allowed identifying genetic and pharmacologic suppressors of dystrophin - dependent muscle degeneration; some of them positively impact mitochondrial functions or structure under stress conditions, or are involved in signaling pathways linked to mitochondria, and others are associated to proteostasis pathways such as autophagy, proteasome and Unfolded Protein Response (UPR).

To better understand how insulin signaling affects beta - cell growth, the Joslin scientists next studied a pathway involving a protein called FOXM1.