Sentences with phrase «signaling proteins such»

«In particular, during this process, miRNA92a interferes with the formation of important signaling proteins such as KLF2 and PTEN.»

«It's long been my hunch that the earliest events in left - right asymmetry involve a shunting [of signaling proteins such as ZIC3] to one side or the other, and it's certainly appealing to invoke dyneins and the cytoskeleton to help with that,» says Casey.

Not exact matches

And so early efforts centered on making sure the gas tank was filled — priming the immune system with cytokines (such as the interleukins) or with immune - signaling proteins like interferon to rev up the tumor - fighting response.

Immunotherapy differs from more traditional cancer treatments, such as surgery (cutting malignant cells out of the body), chemotherapy and radiation (poisoning the deadly mutants), and even the newer, more precise molecular drugs that attempt to jam the protein signals that tell tumor cells to keep dividing and conquering.

Once there, the protein acts on the osteoblasts and inhibits Wnt activity, which is a cellular signalling pathway that is involved in the formation of the skeleton and in certain disorders, such as osteoporosis, arthritis and myeloma.

Sasha De Henau, a researcher at the Biology Department of Ghent University in Belgium recently discovered a globin protein in the roundworm model Caenorhabditis elegans that is able to generate such free radical signals.

Previous studies have shown that such vulnerability can lead to more frequent anxiety, and anxiety is known to activate a metabolic pathway responsible for the production of pro-inflammatory cytokines, signaling proteins that include interleukin - 6 (IL - 6).

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

Now, new research from the Salk Institute shows how a protein called p75 is critical for pain signaling, which could one day have implications for treating neurological disorders as well as trauma such as spinal cord injury.

When activated by inflammatory markers in the gut, it sends a signal to the brain, where immune cells produce proteins such as IL - 6, leading to increased metabolism (and hence decreased levels) of the «happiness hormone» serotonin in the brain.

Therefore, the research shows that these mutations affecting the signalling route which depends on the ATM protein, as well as the drugs inhibiting the function of this signalling route such as some anti-tumour drugs, could produce infertility problems in humans.

This study, published recently in PLOS Genetics, shows that in the particular case of meiotic cells such as spermatocytes, the signalling route of the ATM protein also participates in the control system of the cell cycle progression in response to DNA damage, something which until now was unknown.

Such brainless creatures rely on signals from light - sensitive proteins called opsins.

The ability to track markers inside and outside a cell simultaneously, and to map them atop images showing the cell's shape, is also helping researchers study the metabolic effects of signaling molecules, such as G - protein - coupled receptors.

Senior author Lisa Boulanger, an assistant professor in the Department of Molecular Biology and the Princeton Neuroscience Institute (PNI), said that MHCI's role in ensuring appropriate insulin signaling and synapse density raises the possibility that changes in the protein's activity could contribute to conditions such Alzheimer's disease, type II diabetes and autism.

Although insufficient on its own to trigger leukemia, f - circM9 appears to work together with other cancer - promoting signals (such as the MLL - AF9 fusion protein) to cause disease.

Such a broadband excitation leads to enhanced signal or sensitivity in diverse quantum experiments across fields from protein spectroscopy to quantum optics.

A related study, also published in PLOS Genetics, shows that RPM - 1 functions as a part of a novel pathway to control β - catenin activity — this is the first evidence that RPM - 1 works in connection with extracellular signals, such as a family of protein growth factors known as Wnts, and is part of larger signaling networks that regulate development.

But that is probably not the only route through which neuregulin - 1 confers its benefits, and the group is exploring other possible mechanisms — such as whether the protein improves signaling between neurons, which is impaired in Alzheimer's — says the study's first author Jiqing Xu, a research associate in Lee's group.

The signal for such destruction is provided by attachment of a small ubiquitous protein tag, called ubiquitin.

IL - 33 is a cytokine, a small protein that signals immune cells such as T cells to travel to a site of infection or injury.

Recent studies such as ours, however, establish protein phosphatases as positive and essential regulators of signal transduction, with remarkable substrate specificity and coordinated activities.

They have detected, for example, revved up signaling molecules involved in inflammation, such as tumor necrosis factor α (TNFα) and other cytokines; skewed populations of natural killer cells and other immune cells; imbalances in the protein - destroying enzymes called proteases; and a shortening of the telomeres, the «end caps» on chromosomes, which indicates prematurely aged cells.

The ROBO family of signaling proteins — best known for their role in guiding the growth of developing neurons — regulates the cytoskeleton, and may therefore help cells sense and respond to such changes in their environment.

By identifying the molecular signals emitted through the soil by friendly fungi, the protein enables a plant to «roll out the red carpet» for cell colonisation by the fungi, and all the survival advantages this mutually - beneficial relationship brings — the fungi feeds minerals such as phosphate into plant cells in return for sugar extraction.

Dr. Angulo and his team plan to expand on their findings about this specific patient population by examining data beyond BMI, including fat distribution and differences in cell signaling proteins, such as cytokine and adipokine profiles.

Rats born of hypoxic pregnancy with no vitamin C treatment showed increased thickening of the walls of the aorta — up to 170 % above normal — and molecular markers of disease, such as an increase in the heart's heat shock proteins, a signal of cardiac oxidative stress.

UNISI provides expertise in the measurement of cell signalling proteins, such as cytokines, chemokines and inflammatory biomarkers in multiple samples (including serum, plasma and tissue culture supernatants), using a multiplex suspension array system or a flow cytometric bead assay.

However, it is also possible to induce such responses using protein antigens, if there is a signal that promotes cross-presentation and targeting to specific dendritic cell (DC) subsets with the capacity to cross-present antigens.

Moreover, large - scale screens in the C. elegans DMD model allowed identifying genetic and pharmacologic suppressors of dystrophin - dependent muscle degeneration; some of them positively impact mitochondrial functions or structure under stress conditions, or are involved in signaling pathways linked to mitochondria, and others are associated to proteostasis pathways such as autophagy, proteasome and Unfolded Protein Response (UPR).

We study the maturation enzymes known as proprotein convertases, responsible for generating most secreted signaling proteins, and implicated in diseases such as diabetes, obesity, bone disease, and cancer.

Nutrients such as amino acids (the building blocks of proteins) and sugars and chemical signals such as hormones hitch a ride in the plasma and are carried throughout the body.

It has been observed that this pathway when is activated by upstream signaling cascades [such as growth factor receptors and G - protein coupled receptors (GPCRs)-RSB-, leads to cell proliferation, differentiation and migration.

Protein systems, such as Ras, make up the complex signaling pathways that control whether a cell divides or, in some cases, becomes cancerous and metastasizes into other regions of the body.

We invite original innovative research on the rational engineering of plant systems at all levels, including proteins, protein complexes, sensors, metabolic and signalling pathways, microcompartments such as carboxysomes, subcellular compartments, cell types or tissues, as well as the engineering of novel plant hybrid species and the interactions of plants with viruses, bacteria, and other organisms.

Those signals can also be useful indicators for screening, such as scanning blood or urine for specific compounds or scanning proteins to detect strong or weak binding with a drug candidate.

One way to use such peptides is to block the signaling that runs through the Gα protein, to see what happens in a cell when that signaling is lost and thereby learn what that signaling normally does.

Studies are being carried out to determine the functional effects that occur when these receptor - ligands interact; to determine how these proteins induce their activities at the molecular level and transmit signals to T cells; and to determine the significance of these proteins in several disease scenarios such as asthma, scleroderma, and atopic dermatitis.

The «HIF - 1 signaling pathway» also activates Glycolysis through the activation of different circuits that trigger effector proteins (PDK1, PFKL, ALDOA, etc.) with annotations such as glycolytic process, canonical glycolysis, glucose metabolic process, etc..

Known as potassium channels, the proteins, which control the flow of signals in the nervous system, are implicated in a breathtaking array of functions, such as heart rate maintenance, hormone release, and muscle movement.

1/28/2008 Researchers Map Signaling Networks that Control Neuron Function Relationship between Thousands of Proteins at Work in the Brain Could Impact Diseases such as Alzheimer's, Parkinson's Disease, and Spinal Cord Injury In the first large - scale proteomics study of its kind, researchers at the University of California... More...

The «HIF - 1 signaling pathway» also inhibits Tricarboxylic acid cycle through the inhibition of circuits that trigger the effector protein PDHA1 with diverse GO annotations such as tricarboxylic acid cycle, acetyl - CoA biosynthetic process from pyruvate or carbohydrate metabolic process

It will be important, Panne says, to dissect in detail how scaffold proteins, such as the CBP and p300 co-activators, contribute to the rich gene regulatory language, how such chromatin modifiers are targeted to the genome, how their activity is regulated, and how chromatin modifications contribute to the signaling reaction.

He joined the SGC in 2004 with responsibility for a team producing structures of proteins involved in membrane receptor signalling such as GTPases, 14 -3-3 proteins, RGS domains and PDZ domains.

For example, our studies identified transcription factors, RNA binding proteins, and signaling genes as critical miRNA targets during contexts such as development of peripheral sensory organs, wing, eye, and CNS, or during behavioral contexts such as egg - laying, rhythmic behavior, and locomotor activity (Figure 2).

UNISI will provide expertise in the measurement of cell signalling proteins, such as cytokines, chemokines and inflammatory biomarkers in multiple samples (including serum, plasma and tissue culture supernatants), using a multiplex suspension array system or a Cytometric bead assay.

The broad conservation of neurohormonal signaling pathways between mammalian systems and C. elegans such as insulin - like signaling, serotonin, etc., validates studying the cell non-autonomous control of protein homeostasis by the nervous system of C. elegans to instruct our understanding of age - related human disease.

Gene ontology (GO) analysis of genes within 250 kb of a PORE sequence revealed enrichment in processes such as transcription regulator activity (p < 0.001), sex determination (p < 0.005), insulin receptor signaling (p < 0.001), development (p < 0.0005), and protein phosphorylation (p < 0.005).

Such cells become dysfunctional exporters of harmful signals and oxidized proteins, something that contributes to the progression of atherosclerosis via increased amounts of oxidized lipids in the bloodstream, to pick one example.

Although the reasons why Plasmodium proteins are difficult to express in heterologous expression systems are not clear, several protein characteristics, such as high molecular mass (> 60 kDa), presence of export motifs, and atypical signal peptide sequences negatively impact recombinant expression [12].