Sentences with phrase «signalling axes in»

Ongoing projects aim to define the involvement of these two signalling axes in cancer and to investigate whether the endocytic function of Numb is relevant to its tumour suppressor function.

Not exact matches

The strength of the signal also varied over hours, weeks and months, because of the water vapor plumes rotating in and out of Herschel's views as the object spun on its axis.

Whereas most chiroptical effects result from a response of bound electrons, photoionization can produce much stronger chiral signals that manifest as asymmetries in the angular distribution of the photoelectrons along the light - propagation axis.

But now mission controllers must «focus on new classes of science,» the most exciting of which is using Spirit's radio signal to track the motion of Mars both in its orbit and in its spin on its axis.

With these tools in hand, they determined that in Hofstenia, as in planarians, Wnt signaling controls regeneration along the anterior - posterior (head - tail) axis and Bmp - Admp signaling controls regeneration along the dorsal - ventral (back - belly) axis.

Diverse signaling pathways through the SDF - 1 / CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis.

Central hypothalamic insulin signaling interfered with negative feedback to the hypothalamus - pituitary - adrenal (HPA) axis in stressed male mice (151), which potentially explains high comorbidity rates of mental and metabolic disorders (see section V.P).

The co-incidence of these 2 pathologies occurs also in humans suggesting a common pathological mechanism moving across the gut - joint axis, with TNF signals acting on specific cell types directing pathogenesis at two different locations.

For instance, the role of LIF - gp130 - Stat3 axis in promoting ES cell proliferation is particularly well - defined [1], [3], and BMP - induced differentiation signals are inhibited by a Nanog - Smad1 protein complex [4]; crosstalk between these pathways has also been reported [5].

Here, Dr. Tam presents data characterizing the intracellular signaling pathway associated with the RANK — RANKL axis, as well as the effect in dendritic cells, antigen - specific T cells, cytokines, and chemokine profiles after in vivo treatment with blocking PD - L1 and T cell - depleting antibodies in a melanoma cancer model.

Calcium ions also allow neurons to signal one another, which ties in to the gut - brain - skin axis.

In liver, FGF21 inhibits the GH signaling pathway... Thus, FGF21 - mediated repression of the GH / IGF -1 axis provides a mechanism for blocking growth and conserving energy under starvation conditions.

The HPA axis is composed of the two regulatory control centers in the brain: the hypothalamus and pituitary gland, which secrete stimulatory neurotransmitters that signal the adrenal glands to produce cortisol, the body's main anti-stress hormone.

The term «microbiota - gut - brain axis» is used to describe the complex bidirectional signaling that occurs between the GI tract and the nervous system, and emphasizes the newly recognized role of intestinal microbes in these interactions.

The first thing that seers itself into your line of vision are the 12 panel paintings by Rochelle Feinstein which began in 2008 to mark American - led invasions of the Middle East and the halftone dots forming the outline of globes that seem to be turning on a wobbly axis embody the various definitions of the word «hotspots» as a Wi - Fi signal location, a jumping night spot, central hotbed of activity, etc..

An emerging body of literature24, 25 shows that a subgroup of chronically aggressive children exhibit marked difficulty processing social cues that signal the need to inhibit aggressive impulses.26 These findings have been attributed to reduced responding in specific neural architecture associated with stress responses and HPA axis regulation.