Signalling networks refer to systems or pathways that enable communication and exchange of information between different components or parts of a larger system. It involves transmitting signals or messages to relay specific instructions or signals to coordinate and control the overall functioning of the system.
Full definition
Our approaches include gene discovery, mapping
of signaling networks in cell culture models and in vivo functional analyses done through gene knock - out and knock - in techniques in mice.
This has allowed them to determine one of the most
complex signaling networks that control growth and development in response to environmental change.
Researchers have found a surprising connection between a key DNA - repair process and a
cellular signaling network linked to aging, heart disease, cancer and other chronic conditions.
In particular, his laboratory focuses on the regulation of
key signaling networks that regulate cancer cell growth and survival.
Researchers are also developing rudimentary models of
signaling networks in cells and simple brain circuits.
At the cell biology level, our interest focuses
on signalling networks regulated by G - protein - coupled and growth factor receptors.
In other disease areas, the Parkinson's disease map and the Atlas of
Cancer Signalling Network, have already begun the process of integrating knowledge about the involved mechanisms in order to understand the different subtypes of these diseases.
To this end Dr. Linding is currently leading high - level, strategic, multidisciplinary studies of
signaling network dynamics driving cancer metastasis in collaboration with other labs at Harvard, Yale, The Jackson Laboratory, Memorial Sloan Kettering Cancer Center, MIT, and BRIC.
Using DOS and small - molecule screening, Schreiber helped illuminate many cellular pathways, including the nutrient - response
signaling network involving TOR proteins in yeast and mTOR in mammalian cells.
Kilian's main research interests comprise the functional exploration of cellular
signaling networks by the development of specific chemical probes and chemical biology approaches apt to identify new therapeutic targets relevant for the treatment of human disease.
The December 2011 e-publication AMP - activated protein kinase (AMPK) controls the aging process via an
integrated signaling network makes the point that control of Nrf2 along with control of other key pathways by AMPK drives aging.
Kuchenov D, Laketa V, Stein F, Salopiata F, Klingmueller U, Schultz C: High - Content Imaging Platform for Profiling
Intracellular Signaling Network Activity in Living Cells.
We're going to roll out high - speed broadband, and put in place a modern wireless and
mobile signal network across Wales.»
In the most recent study, M.D. / Ph.D. student Risheng Xu worked with other members of Snyder's team to investigate whether cocaine works through the
NO signaling network, and if so, how.
The group has already started tweaking human iPS cells using the same genes that Saitou pinpointed as being important in mouse germ - cell development, but both Saitou and Hayashi know that
human signalling networks are different from those in mice.
Their work implicated the Ras pathway — a calcium -
dependent signaling network that spurs neuronal growth — as playing a key role in autism.
Moreover, the scientists have found that these stem cells depend upon a family of proteins known as the «
Wnt signaling network» — the same proteins that play a crucial role in hair and tissue regeneration — to regenerate bone in the fingertip.
In previous studies on rodents, postdoctoral scholar Clemenson and others showed that exploring the environment resulted in the growth of new neurons that became entrenched in the hippocampus» memory circuit and increased
neuronal signaling networks.
A related study, also published in PLOS Genetics, shows that RPM - 1 functions as a part of a novel pathway to control β - catenin activity — this is the first evidence that RPM - 1 works in connection with extracellular signals, such as a family of protein growth factors known as Wnts, and is part of
larger signaling networks that regulate development.
A strategic focus is to continue to develop computational tools (such as KinomeXplorer, NetworKIN, and NetPhorest) and to deploy these on genome - scale quantitative data obtained by, for example, mass spectrometry, genomic, and phenotypic screens to understand the principles of how spatio and temporal assembly of
mammalian signaling networks transmit and process information at a systems level in order to alter cell behavior.
Among the unexpected «hits» revealed by this assay were a cyclic
AMP signaling network and a group of transcription factors important in melanocyte development, each suggesting potential new strategies for overcoming resistance.
The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and
signaling networks found in human biology having first been discovered in yeast.
In addition, the analysis provided some hints about how chemotaxis evolved from a
simple signaling network that responds slowly to environmental cues — primarily by turning on genes — to a multiprotein system that can quickly alter a cell's course.
Via the fat molecules produced, called fatty acids, FASN also regulates an
entire signal network that plays an important role in myelination.
Now the Strader and Jez labs at Washington University in St. Louis have made a discovery about one of the proteins in the
auxin signaling network that may prove key to understanding the entire network.
We are also interested in other neuronal functions of the
TSC signaling network, such as the control of neuron size, myelination, survival and stress responses.
Zhang, Y. and Wolf - Yadlin, A. and Ross, P. L. and Pappin, D. J. and Rush, J. and Lauffenburger, D. A. and White, F. M. (2005) Time - resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor
receptor signaling network reveals dynamic modules.
What's next: In a related article not yet published, the same team of researchers shows that
biological signaling networks can be understood in the context of human - engineered electrical and mechanical systems.
In August 2016, Brooke joined the faculty at SBP Medical Discovery Institute as an Assistant Professor in the Cancer Metabolism and
Signaling Networks Program.
The clustering of transmembrane receptors into defined nanoscale structures triggers and regulates
specific signaling networks with unprecedented precision and is involved in transducing forces between the cell and the matrix.
The application of surfaces that present a specific spatial pattern of molecules and peptides at the nanoscale have elucidated the minimal requirements needed for
activating signalling networks.
These data, together with the finding that knockdown of both TAZ and STAT5 phenocopied the decrease in breast cancer cell metastasis caused by ABL1 / ABL2 depletion, supports a model for a requirement of ABL - dependent TAZ and
STAT5 signaling networks in promoting breast cancer metastasis (Fig. 8B).
In addition, we prepared a large number of tools to
manipulate signalling networks and are able to locally activate the important messenger such as PIP3 and DAG with a light flash in subcellular resolution in living cells (Mentel et al. 2011; Nadler et al. 2013, Nadler et al. submitted).
The DNA damage checkpoint regulated by the ATM and ATR kinases is the
main signaling network that controls the cellular responses to DNA damage.