Sentences with phrase «signals leading to cancer»

Not exact matches

JCAR017 uses a defined CD4: CD8 cell composition and 4 - 1BB as the co-stimulatory signaling domain to mimic a «second signal» that amplifies the activation of CAR T cells, which according to Juno leads to a more robust signal to the T cell to multiply and kill the cancer cell.

Improved understanding of the biology of cancer cells has led to the development of biological agents that mimic some of the natural signals that the body uses to regulate growth.

The researchers used a drug called clorgyline to inhibit the activity of the MAOA enzyme; the drug disrupted the signaling system that led to cancer cell invasion and proliferation.

Joe W. Ramos, PhD, deputy director of the UH Cancer Center and collaborators focused on investigating how these oncogenes and related signals lead to dysregulation of normal processes within the cell and activate highly mobile and invasive cancer cell behCancer Center and collaborators focused on investigating how these oncogenes and related signals lead to dysregulation of normal processes within the cell and activate highly mobile and invasive cancer cell behcancer cell behavior.

When mutated, BRAF, an enzyme that acts in a signaling cascade known as the MAPK / ERK pathway, becomes overactive and leads to increased cellular growth, a hallmark of cancer.

The new chimera interferes with HER2 and HER3 signaling and ultimately leads to cancer cell death, as shown in the group's recent publication in Molecular Therapy: Nucleic Acids.

Meanwhile, cancer genome projects have yielded unprecedented insights into the cellular signaling pathways that drive the development and progression of cancer — information that has led to effective therapies tailored for individual patients.

«Beta blockers may lead to new novel triple negative breast cancer treatments: New research suggests that adrenaline can act on tumor cells via a cell surface receptor called the beta2 - adrenoceptor and that changes in signaling within the cell make it highly invasive.»

To this end Dr. Linding is currently leading high - level, strategic, multidisciplinary studies of signaling network dynamics driving cancer metastasis in collaboration with other labs at Harvard, Yale, The Jackson Laboratory, Memorial Sloan Kettering Cancer Center, MIT, andcancer metastasis in collaboration with other labs at Harvard, Yale, The Jackson Laboratory, Memorial Sloan Kettering Cancer Center, MIT, andCancer Center, MIT, and BRIC.

«The researchers now plan to team up with other world - leading experts in cancer signalling based in Manchester including Professor Nic Jones, Director of MCRC and Cancer Research UK Chief Scientist who heads the Cell Regulation Laboratory, which studies how cells respond to sudden adverse changes in their surroundings, known as environmental scancer signalling based in Manchester including Professor Nic Jones, Director of MCRC and Cancer Research UK Chief Scientist who heads the Cell Regulation Laboratory, which studies how cells respond to sudden adverse changes in their surroundings, known as environmental sCancer Research UK Chief Scientist who heads the Cell Regulation Laboratory, which studies how cells respond to sudden adverse changes in their surroundings, known as environmental stress.

Poznansky's team — with lead scientist Huabiao Chen, PhD, corresponding author of the current report — had been investigating applications of AMD3100, a drug that blocks the CXCR4 / CXCR12 signaling pathway known to be involved in cancer development and in the way in which mesothelioma evades the immune system.

Evan Paull, a graduate student in Stuart's lab at UC Santa Cruz (now at Columbia University), led the computational analyses, which involved integrating the phosphoproteomic data with genomic and gene expression datasets to provide a unified view of the activated signaling pathways in late stage prostate cancer.

Once the bacterial cell signaling protein cagA reaches the host cytosol, it is capable of altering subsequent generations of progenitor cells, leading to the development of cancer through changes in mitotic activity, apoptosis, cellular assembly, and signaling.26 Although it should be noted that while the presence of the cagA protein doubles the risk of gastric cancer, cagA - negative strands also increase the risk of distal gastric cancer.27 Additional H pylori virulence factors include babA2, which encodes bacterial adhesion with gastric epithelial cells, and vacuolating cytotoxin A, which is encoded by the gene vacA.28, 29 H pylori strains carrying some combination of the babA2, cagA, and vacA genes were associated with the highest risk of developing intestinal metaplasia.

Klemke, Wang, and their colleagues are involved in research on aspects of the basic biology behind metastasis — trying to identify the signal transduction mechanisms that lead to the spread of breast cancer cells.

Diverse signaling pathways through the SDF - 1 / CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

Moreover, these ATP - competitive inhibitors induce the formation of B - RAF and C - RAF dimers, leading to extracellular signal — regulated kinase (ERK) activation in diverse cancer cell types (23).

Interferon signaling is central to the innate immune system, so answers to these questions also can lead to better understanding of cancers and diseases and new drugs related to immune activity or malfunction.

Together, these data revealed a functional link between the ABL kinases and TAZ signaling leading to increased AXL abundance in breast cancer cells, and identified a potentially druggable pathway for the treatment of breast cancer bone metastasis.

His latest interest in microscopy grew out of a fascination with cell signaling and how dysfunctions in the process can lead to cancer.

She plans to test whether or not molecules designed to target the marker can block the signaling necessary for maintaining the cells» stem - like properties, which could lead to new antibody - based immunotherapies for breast cancer.

And 2) to inhibit WNT signaling in breast cancer cells or mammary epithelial cells and test whether this leads to reduced miR - 150 expression.

The «typical» high - protein dietary recommendations promoted on BB websites lead to increased IGF1 and mTOR signalling which is not very healthy for an adult as these are growth factors that tend to grow things (e.g. cancer) that we are not looking forward to.

Not only that, increased levels of IGF signaling lead to increased growth of cancer cells already present in our bodies.