Our previousstudyof 11 NSCL / P associated SNPs [20] showed some borderline significance for association with nose - width and bizygomatic distance but inconsistent effect was observed in two populations studied (Rotterdam and Essen).
Based on previousstudies, it was determined that an n of 23 was adequate to defend the 0.05 alpha level ofsignificance with a Cohen probability level of 0.8 (G - Power software, version 3.1.2; Franz Foul, Kiel University, Kiel, Germany).