Sentences with phrase «significant advance with»

The Stretch Compact The most significant advance with this latest Corolla is the improvement in interior room and quality.

Don't get me wrong, I'm not saying they should leave cel - shading behind — it's a major asset and a large percentage of its appeal and charm — but that I hope they're making significant advances with the facial animations and general movement so that character interactions don't seem as stiff.

Not exact matches

Indeed, even if your top line revenues were to stay flat for the next few years, there are ways to make significant advances to your bottom line growth with some simple, if not occasionally controversial, concrete steps.

This conversation shows that they're in your plan and that you can see them not only long - range with your organization, but also advancing and playing a significant role.

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

«As a part of the Nohla team, I look forward to advancing the development of its cell therapy programs for patients with significant unmet needs.»

Despite making significant progress with the technology, automakers face a battle to bring their advance prototype vehicles to market in Europe and the United States due to regulatory hurdles and questions about product liability.

It is a significant award and prove of trust to the advancing Vietnamese hi - tech startup scene, which enables us to close such strategic international partnerships with world - wide industry - leading companies like Coinify.

To this, currency hedge funds that focus on CAD to USD usually use advanced strategies and algorithms to follow the movements of currencies with significant trading volumes.

Through the use of advanced radar technology combined with data collected from Tesla's Fleet Learning program, the vehicle is able to capture a continuous picture of the world and provide significant enhancements to emergency braking capabilities.

Considered as «the most advanced hardware portfolio on the market today,» the Ledger Blue brings a significant difference with the thumbdrive style of Ledger's previous products, it is a portable touch screen device that can run a number of different applications.

When women routinely win Nobel Prizes in physics, chemistry or medicine, when a woman becomes a world chess champion, when a woman conceives and develops a brand new computer chip that represents a significant advancement over quad cores, when a woman invents warp drive or phasers, when a woman solves an «insolvable» math problem, when a woman, while working with the Large Hadron Collider, discovers the now - hypothetical Higgs Boson to be an actual scalar subatomic particle, when a woman figures out how to pinpoint the exact location of an electron at any point in time, when a woman working for Merck or Pfizer develops a remedy for Alzheimer's disease, when a woman's baseball team can defeat the New York Yankees, when a woman can bench press six hundred pounds, run the 100 meter dash in under nine seconds or set a world record in the high jump, then the fairer sex will have made an advance or contribution unlike any it has made before.

• The central element in the Church plan is a powerful, well - informed Senate oversight committee with rotating membership, budgetary authority, legislative powers, and the right to receive advance notice of all «significant» covert operations.

There have been significant advances toward greater Christian unity in recent decades, but it is still the case that communities of self - identified affinity have greater confidence when they are gathering with their own.

The Oxford Conference; with certain limitations, made significant advances in these directions.

Chobani recently brought in significant resources and continues to work with internal as well as outside experts to assemble one of the most advanced food safety and quality systems in the industry.

Liverpool's need for reinforcements out wide could be even greater than United's as well, with reports today from the Daily Mirror suggesting that star player Raheem Sterling is in advanced talks over an exit from the club after Manchester City made significant progress with a # 45m bid.

If you don't remember, back in 2007 the NFL made it illegal for defensive players to make significant contact with a receiver when they have advanced five yards beyond the line of scrimmage.

For 2018, the Mini (3 Night / Day) and Intermediate / Advanced (5 Night / Day) programmes is attracting significant early interest, with a large group of quality players expected to sign up.

I won't dwell too much on the return journey other than the fact that two significant road closures meant that I didn't arrive home until almost 2 am, when I would have been in before midnight without the M11 and A12 being totally closed off for road works at important junctions, with no advance warning that I was aware of.

It is difficult to find fault with this phone though, just as with all modern smartphones running so many apps, battery life is an issue and will remain so until significant advances are made in battery technology.

Advances in research would not only help providers to have a better understanding of the way depression severity and its course interacts with program elements to bring about positive or negative outcomes, but it may also help home visitors to receive better training that support their work with mothers who have significant depression.

With advances in surgical techniques for breast reductions, surgeons are increasingly able to preserve milk - producing tissue so that women who have had breast reductions are able to produce significant amounts of milk.

President Tusk underlined the need to advance in the fight against corruption, safeguard the significant progress achieved and ensure its irreversibility, in line with the high expectations of Romanian society and the EU's values.

Among the nine criteria used to evaluate projects are the location of the development in relation to the municipality's master plan, efforts to advance the creation of walkable neighborhoods, a «significant unmet need» in the community for senior housing, and whether the project will be at least 50 % occupied by seniors with an income at or below 60 % of the median income in Erie County.

WHEREAS, women make up 50 % of the population in Santa Clara County but face significant economic disparities, with an average pay difference that is larger than the national wage gap of $.72 for a man's dollar, with women holding advanced degrees earning roughly $ 40,000 less than their male counterparts, and 11 % of the County's female population living in poverty and approximately 33 % of the homeless population being women and girls, and

A clinical trial conducted by researchers at the Virginia G. Piper Cancer Center Clinical Trials, a partnership between Scottsdale Healthcare and the Translational Genomics Research Institute (TGen), showed that a new drug called MM - 398, given in combination with 5 - flourouracil (5FU) and leucovorin, produced a significant overall survival rate in patients with advanced, previously - treated pancreatic cancer.

«A significant number of advanced prostate cancer patients treated with a chemical castration therapy called androgen deprivation therapy (ADT) experience relapse with relentless progression to lethal metastatic, castration - resistant prostate cancer,» said Ronald DePinho, M.D., professor of Cancer Biology.

This is significant because right - sided colon cancer is easier to miss with screening and more likely to be found larger or more advanced than left - sided cancers.

Researchers at Tohoku University's Advanced Institute for Materials Research (AIMR) have carried out a collaborative study aimed at precisely controlling phase transformations with high spatial precision, which represents a significant step forward in realizing new functionalities in confined dimensions.

When 45 cancer patients, most with advanced melanoma, took a cocktail of the BRAF and MEK inhibitors, there were few significant side effects.

With regards to the implementation of EGS technology, the authors recognise that there are still significant problems that must be researched, such as the appropriate perforation technique, the best way of fracturing the rock or how to operate advanced thermodynamic cycles.

This approach to synthesizing the material is a significant advance towards realizing electrocatalysts with superior catalytic properties and lower cost.

The new molecule represents a significant conceptual advance that could help scientists realize the decades - old goal of better controlling diabetes with a glucose - responsive insulin, says Michael Weiss, a professor of biochemistry and medicine at Case Western Reserve University.

«In conclusion, the study by Carrero et al in this issue of JAMA provides the best evidence to date that vitamin K antagonists [anticoagulants] are associated with improved clinical outcomes and no significant increased risk of bleeding in patients with myocardial infarction and atrial fibrillation with advanced CKD.»

With thin film technology the bedrock of microchip and microstructure manufacturing, the pioneering research offers a significant advance — potential applications range from thin film coatings for paint and wound care to 3D printing, micro-casting and micro-fluidics.

With an advance that one cryptography expert called a «masterpiece,» University of Texas at Austin computer scientists have developed a new method for producing truly random numbers, a breakthrough that could be used to encrypt data, make electronic voting more secure, conduct statistically significant polls and more accurately simulate complex systems such as Earth's climate.

«This paper demonstrates that despite all of the advances made over the last 100 years, the experience of discrimination continues to be a significant problem for people with epilepsy,» said Dr. Victoria Nimmo - Smith, first author of the Epilepsia study.

Researchers said the gains are a significant advance in their ongoing work to develop and test a practical BCI assistive technology that people with paralysis could use easily, reliably, independently, and on demand to regain control over external devices.

«These results represent a significant advance in our understanding of how commensal microbes can regulate host intestinal immune responses and suggest that the identification of downstream targets in macrophages and dendritic cells along the GM - CSF axis can help the rationale design of novel strategies for the treatment of IBD patients with defective GM - CSF function,» explained Dr. Merad.

This «landmark study» is a «significant advance in the application of bioengineering to reproductive tissues,» says Mary Zelinski, a reproductive scientist at the Oregon National Primate Research Center in Beaverton who was not involved with the work.

Scientific collaboration offers significant opportunities to advance biological science to address these and other national priorities and discuss shared principles and standards of practice to minimize risks associated with the research.

A recent study at the Beckman Institute for Advanced Science and Technology at the University of Illinois found that, matched calorie for calorie with the simple sugar glucose, fructose causes significant weight gain, physical inactivity, and body fat deposition.

Particularly successful in my view, is the interleaving of chronological chapters with those which deal with culturally significant technological advances.

«This study results are significant in helping to advance medical alternatives for patients with immune tolerant Hepatitis B, a sub-group of patients who thus far, doctors have been hesitant to treat,» said Professor Tom Hemming Karlsen, EASL Vice-Secretary.

Grigorescu said: «Our study shows that there are significant gaps in the delivery of palliative care for patients with advanced, incurable cancer.

A research advance co-led by Case Western Reserve University School of Medicine's Kumar Alagramam, PhD, may stop the progression of hearing loss and lead to significant preservation of hearing in people with Usher syndrome type III, a form of hereditary hearing loss linked to defects in the sensory «hair» cells in the inner ear.

«In recent years we've seen a significant improvement in the length of good - quality life men can hope to live even with the most advanced prostate cancers — thanks to clinical trials giving us several new prostate cancer drugs.

This represents a significant advance on attosecond experiments involving excitation with a single attosecond XUV photon.

This work, which has been done in collaboration with the group of Dr Carmen Guaza of the Instituto Cajal in Madrid, and Dr X. Montalban and Dr M. Comabella of the Val d'Hebron Institut de Recerca in Barcelona, constitutes a significant advance in the understanding of the biology of the ANKRD55 gene and of the proteins it expresses, given that a new player has been discovered in the neuro - inflammation process that takes place in Multiple Sclerosis.