Sentences with phrase «significant adverse effect»

A diagnosis of psychological maltreatment is facilitated when a documented event or series of events has had a significant adverse effect on the child's psychological functioning.

He held that in making this judgment, a competent authority is not obliged to disregard any measures incorporated into the proposal which are designed to avoid or mitigate adverse habitat effects, observing that it would be «ludicrous» for a decision maker to have to disaggregate the different elements of the package, or require an appropriate assessment on the basis that the proposals (considered without the mitigating measures) would be likely to have a significant adverse effect, only for the package to have to be reassembled when carrying out the appropriate assessment.

(b) No person concerned with the testing process may declare a test cancelled based on an error that does not have a significant adverse effect on the right of the employee to have a fair and accurate test.

(b) No person concerned with the testing process may declare a test cancelled based on a mistake in the process that does not have a significant adverse effect on the right of the employee to a fair and accurate test.

We find no significant adverse effect of refugees on the educational outcomes of incumbent students including test scores, disciplinary incidents, and student mobility across schools.

In non-obese, healthy adults, 25 % CR decreases inflammation with no significant adverse effect.

Any of these factors could have a significant adverse effect on our business, financial condition, results of operations, and prospects.

In addition, there are proposals for tax legislation that have been introduced or that are being considered that could have a significant adverse effect on our tax rate, the carrying value of deferred tax assets, or our deferred tax liabilities.

These developments, or the perception that any of them could occur, have had and may continue to have a significant adverse effect on global economic conditions and the stability of global financial markets, and could significantly reduce global market liquidity and restrict the ability of key market participants to operate in certain financial markets.

HAZELTON — A federal environmental assessment report that concluded the proposed New Prosperity open - pit mine would have significant adverse effects for the Tsilhqot» in is a condemnation of the B.C. Liberals approach to Aboriginal rights and title, says Stikine MLA Doug...

Mass Audubon does not interfere with the natural water regime of wetlands on our properties to control mosquitoes, because of the significant adverse effects on wildlife and the natural system as a whole.

«What I found surprising was that one needs rather larger velocities, a per cent of the speed of light in a vacuum, to see significant adverse effects,» he says.

Preclinical testing provided evidence that ebselen is safe and tolerable, and it has shown no significant adverse effects in ensuing clinical trials.

Rissman said R121919 was well - tolerated by AD mice (no significant adverse effects) and deemed safe, suggesting CRF - antagonism is a viable, disease - modifying therapy for AD.

I don't know of any significant adverse effects, although erosion is beginning to be a problem in some places, since all the tourists are obliged to keep to the same trails.

Secondary prevention trials showed significant adverse effects of n - 6 LA on coronary heart disease mortality (1.84 (1.11 to 3.04); P = 0.02; web appendix, part 8).

The only results released by the study's sponsor, Geron of Menlo Park, Calif., indicate that neither patient has suffered any significant adverse effects.

People who drank either red or white wine also reported better sleep quality than the group that drank water, and the researchers found no significant adverse effects with any group.

Generally, though not always, your creditors will freeze the interest and penalties on your debts so that your reducing your monthly payment doesn't have significant adverse effects in the long run on the amount you need to pay back.

For pets, being overweight can have significant adverse effects on their health and quality of life, and leads to the premature death of millions each year.

Recalling the concern reflected in the outcome document of the United Nations Conference on Sustainable Development, entitled «The future we want», 1 that the health of oceans and marine biodiversity are negatively affected by marine pollution, including marine debris, especially plastic, persistent organic pollutants, heavy metals and nitrogen - based compounds, from numerous marine and land - based sources, and the commitment to take action to significantly reduce the incidence and impacts of such pollution on marine ecosystems, Noting the international action being taken to promote the sound management of chemicals throughout their life cycle and waste in ways that lead to the prevention and minimization of significant adverse effects on human health and the environment, Recalling the Manila Declaration on Furthering the Implementation of the Global Programme of Action for the Protection of the Marine Environment from Land - based Activities adopted by the Third Intergovernmental Review Meeting on the Implementation of the Global Programme of Action for the Protection of the Marine Environment from Land - based Activities, which highlighted the relevance of the Honolulu Strategy and the Honolulu Commitment and recommended the establishment of a global partnership on marine litter, Taking note of the decisions adopted by the eleventh Conference of the Parties to the Convention on Biological Diversity on addressing the impacts of marine debris on marine and coastal biodiversity, Recalling that the General Assembly declared 2014 the International Year of Small Island Developing States and that such States have identified waste management among their priorities for action, Noting with concern the serious impact which marine litter, including plastics stemming from land and sea - based sources, can have on the marine environment, marine ecosystem services, marine natural resources, fisheries, tourism and the economy, as well as the potential risks to human health; 1.

KR asks the correct question finally, as to what we would do if human CO2 production was the cause of significant global warming with significant adverse effects.

On the contrary, I believe there should be freedom of energy use and selection as long as there are no significant adverse effects on others.

Raincoast Conservation Foundation and Living Oceans Society argued that the NEB and Cabinet failed to comply with the statutory requirements of the Species at Risk Act (SARA) with respect to the significant adverse effects of the Project on southern resident killer whales and their critical habitat.

Therefore, federal assessment of impacts in these areas with a view to preventing significant adverse effects is likely intra vires, even when there is no decision to be made under other Federal statutes.

A combination of contractual compellability, a reduced standard of proof, and a suboptimal system of investigating and adjudicating complaints, could have significant adverse effects not only for the administration of justice but also for the health services.

Carbamazepine was effective in a pilot study; however, multiple significant adverse effects occurred.

Not exact matches

The Panel found that, «the likelihood of significant adverse environmental effects resulting from project malfunctions or accidents is very low,» but they did allow that a spill would involve significant adverse environmental effects.

«The most significant drag is primarily felt by emerging market economies, who tend to be more sensitive to shifts in global risk sentiment, which can also have large adverse effects on capital flows and currency valuations,» the note said.

The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations.

As a result, political instability, labor strikes, natural disasters or other events resulting in the disruption of trade or transportation from other countries or the imposition of additional regulations relating to duties upon imports could cause significant delays or interruptions in the supply of our merchandise or increase our costs, either of which could have an adverse effect on our business.

As a result, there can be no assurance that a significant change in market interest rates will not have a material adverse effect on our net investment income.

Thus, while concluding that the NGP is likely to result in significant adverse environmental effects with respect to caribou and grizzly bears, the JRP recommended that these «can be justified in the circumstances, as set out in Chapter 2» (see NGP Report, Volume II, Chapter 8, Environmental Assessment).

There are other aspects of the NGP Report that merit further discussion, including its approach to adaptive management (we now have three different JRP reports in as many years that take different views on the extent to which AM can be relied upon in making a determination as to the likelihood of significant adverse environmental effects under CEAA), the precautionary principle, species at risk and Aboriginal consultation.

The Governor in Council accepted the panel's recommendations that the pipeline will have significant adverse environmental effects to populations of woodland caribou and grizzly bears, but that these effects are justified in the circumstances.

President Akufo - Addo was confident that these measures will enable the country attain a significant level of self - reliance, promote industrialisation and provide adequate cushion against the adverse effects of price shocks.

«Infertility is becoming a significant public health issue because of unexpected adverse effects on the health and quality of life and heavy expenditures on the health system,» said Dr. Jin - Young Min, the study's co-author.

«However, as immunosuppression drugs required for transplantation can have significant adverse side effects, the treatment only makes sense for people who have frequent severe hypoglycemia despite optimal diabetes management, or for those already on immunosuppressant drugs for a kidney transplant, a group being studied in another Phase 3 trial.»

«No significant safety concerns or dose - dependent adverse side effects of AVI - 7288 were reported with respect to any safety end point evaluated,» said Michael Wong, M.D., senior medical director for infectious diseases at Sarepta.

According to Bonn - Miller, a number of products also contained a significant amount of THC — the chemical compound in cannabis responsible for making a person feel «high» — which has been shown cause cognitive impairment and other adverse health effects.

In the category «side effects,» significant effects were shown in favour of brivaracetam (for serious adverse events and some specific adverse events, such as dizziness or eye disorders).

For many medications, inherited differences in patients» ability to metabolize, transport, and eliminate drugs and in the characteristics of drug targets and receptors are significant determinants of therapeutic or adverse effects of medications.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

(Although side effects other than myalgia weren't formally tracked, there were «no significant adverse events» in the patients taking red yeast rice, Dr. Becker says.)

A small clinical trial showed a statistically significant improvement in atopic dermatitis (eczema) lesions after application of Manuka honey applied overnight after 1 week without any adverse effects.

The EPA publishes a reference dose (RFD) for silver which is an estimate of daily exposure to the entire population that is unlikely to be associated with a significant risk of adverse effects over a lifetime.

Skeptics might counter that this could be largely the placebo affect, but in the absence of any adverse effects and considering that placebo works a significant percentage of the time, I'd still consider it worth a try.

No fewer than 28 clinical trials in humans have shown that pantethine produces significant positive changes in triglycerides, LDL cholesterol, and VLDL, along with increases in HDL cholesterol.5 In all of these trials, virtually no adverse effects were noted.

And because collagen has such a significant impact on how our bodies function, losing it causes some adverse side effects.

The typical dosage of NAC given as an oral supplement in clinical trials is 600 mg b.i.d., although 200 mg t.i.d. has been shown to provide benefit in just 8 weeks.27 On the other hand, doses as high as 1 gram t.i.d. have been used in cystic fibrosis patients for 4 - 12 weeks with no adverse effects, and in AIDs patients, oral NAC doses up to 8 grams / day did not cause clinically significant adverse reactions.42 43 44 45 46 47