Sentences with phrase «significant adverse effects for»

HAZELTON — A federal environmental assessment report that concluded the proposed New Prosperity open - pit mine would have significant adverse effects for the Tsilhqot» in is a condemnation of the B.C. Liberals approach to Aboriginal rights and title, says Stikine MLA Doug...

Not exact matches

In addition, there are proposals for tax legislation that have been introduced or that are being considered that could have a significant adverse effect on our tax rate, the carrying value of deferred tax assets, or our deferred tax liabilities.

«However, as immunosuppression drugs required for transplantation can have significant adverse side effects, the treatment only makes sense for people who have frequent severe hypoglycemia despite optimal diabetes management, or for those already on immunosuppressant drugs for a kidney transplant, a group being studied in another Phase 3 trial.»

Rissman said R121919 was well - tolerated by AD mice (no significant adverse effects) and deemed safe, suggesting CRF - antagonism is a viable, disease - modifying therapy for AD.

«No significant safety concerns or dose - dependent adverse side effects of AVI - 7288 were reported with respect to any safety end point evaluated,» said Michael Wong, M.D., senior medical director for infectious diseases at Sarepta.

According to Bonn - Miller, a number of products also contained a significant amount of THC — the chemical compound in cannabis responsible for making a person feel «high» — which has been shown cause cognitive impairment and other adverse health effects.

In the category «side effects,» significant effects were shown in favour of brivaracetam (for serious adverse events and some specific adverse events, such as dizziness or eye disorders).

For many medications, inherited differences in patients» ability to metabolize, transport, and eliminate drugs and in the characteristics of drug targets and receptors are significant determinants of therapeutic or adverse effects of medications.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

The EPA publishes a reference dose (RFD) for silver which is an estimate of daily exposure to the entire population that is unlikely to be associated with a significant risk of adverse effects over a lifetime.

The typical dosage of NAC given as an oral supplement in clinical trials is 600 mg b.i.d., although 200 mg t.i.d. has been shown to provide benefit in just 8 weeks.27 On the other hand, doses as high as 1 gram t.i.d. have been used in cystic fibrosis patients for 4 - 12 weeks with no adverse effects, and in AIDs patients, oral NAC doses up to 8 grams / day did not cause clinically significant adverse reactions.42 43 44 45 46 47

History of safe traditional use No case reports of significant adverse events with high probability of causality No significant adverse events in clinical trials No identified concerns for use during pregnancy or lactation No innately toxic constituents Toxicity associated with excessive use is not a basis for exclusion from this class Minor or self - limiting side effects are not bases for exclusion from this class»

After being on the market for over 12 years with over a million customers worldwide, the formula for Asensia ® has never been known to cause any significant adverse side effects.

Therefore, it is important to appreciate that the many ultra-low carbohydrate diets that are now in vogue for so many in the nutritional community, while they may be beneficial for those individuals who have, for years, ingested a diet high in poor quality carbohydrates, can have an adverse effect on the gut when they are employed in excess for a significant period of time.

I buy TLI's argument that adverse - selection means folk who knew they only had a short life - expectancy will not have sold their policies, (hence my analysis is over-pessimistic) but am surprised this effect still persists after 6 + years (no significant turn up in mortality - rates pa towards those appropriate for their age so far).

If the landlord is ultimately successful in its complaint, we may be liable for significant damages in connection with the alleged early termination of the lease and may lose assets related to the biopharmaceutical manufacturing facility we have constructed within the leased premises, which could have a material adverse effect on the our financial position, results of operations or cash flows.

For pets, being overweight can have significant adverse effects on their health and quality of life, and leads to the premature death of millions each year.

The therapeutic dotential of dietary precursor modulation by a fish - oil - supplemented diet (n - 3 fatty acids), such as eicosapentaenoic acid (C20: 5,n - 3) and docosahexaenoic acid (C22: 6,n - 3) in the therapy of ulcerative colitis has been shown to result in a 35 % to 50 % decrease in neutrophil production of LTB4.28 Significant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fSignificant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fsignificant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fatty acids.

The primary current problem is that the climate alarmists are creating enormous problems in the generation and use of reliable energy necessary for the development and even the continuation of modern civilization, with adverse effects on the economy, human welfare, and even the environment, all for no significant benefits to anyone except vendors of renewable energy facilities.

Recalling the concern reflected in the outcome document of the United Nations Conference on Sustainable Development, entitled «The future we want», 1 that the health of oceans and marine biodiversity are negatively affected by marine pollution, including marine debris, especially plastic, persistent organic pollutants, heavy metals and nitrogen - based compounds, from numerous marine and land - based sources, and the commitment to take action to significantly reduce the incidence and impacts of such pollution on marine ecosystems, Noting the international action being taken to promote the sound management of chemicals throughout their life cycle and waste in ways that lead to the prevention and minimization of significant adverse effects on human health and the environment, Recalling the Manila Declaration on Furthering the Implementation of the Global Programme of Action for the Protection of the Marine Environment from Land - based Activities adopted by the Third Intergovernmental Review Meeting on the Implementation of the Global Programme of Action for the Protection of the Marine Environment from Land - based Activities, which highlighted the relevance of the Honolulu Strategy and the Honolulu Commitment and recommended the establishment of a global partnership on marine litter, Taking note of the decisions adopted by the eleventh Conference of the Parties to the Convention on Biological Diversity on addressing the impacts of marine debris on marine and coastal biodiversity, Recalling that the General Assembly declared 2014 the International Year of Small Island Developing States and that such States have identified waste management among their priorities for action, Noting with concern the serious impact which marine litter, including plastics stemming from land and sea - based sources, can have on the marine environment, marine ecosystem services, marine natural resources, fisheries, tourism and the economy, as well as the potential risks to human health; 1.

In addition, Article 9 states that the provision of scaled - up financial resources should aim to achieve a balance between adaptation and mitigation, taking into account country - driven strategies, and the priorities and needs of developing country Parties, especially those that are particularly vulnerable to the adverse effects of climate change and have significant capacity constraints, such as the least developed countries and small island developing States, considering the need for public and grant - based resources for adaptation.

EPA's attempt to regulate emissions of carbon dioxide would also be a disaster if the Trump Administration allows the Obama regulations to be implemented since CO2 is not a pollutant, does not have a significant effect on global temperatures, and would have had huge adverse effects on the economy, on plants, and on poor people for no purpose.

This was a very significant case for women's equality rights as it gave LEAF and its coalition partners an opportunity to elaborate on the key human rights concepts of adverse - effect discrimination and the duty to accommodate, as well as to argue against the idea of «reverse discrimination».

Most readers will know that this was Taseko's second attempt to secure federal approval for its proposed mine and that the federal review panel that conducted the second environmental assessment (EA) concluded that, like the original Prosperity project, it too was likely to result in significant adverse environmental effects (SAEEs)(for more on the panel's report, see my previous post here)...

He held that in making this judgment, a competent authority is not obliged to disregard any measures incorporated into the proposal which are designed to avoid or mitigate adverse habitat effects, observing that it would be «ludicrous» for a decision maker to have to disaggregate the different elements of the package, or require an appropriate assessment on the basis that the proposals (considered without the mitigating measures) would be likely to have a significant adverse effect, only for the package to have to be reassembled when carrying out the appropriate assessment.

This is significant as for many reviewable practices under the Act (whether unilateral conduct, mergers or non-criminal agreements between competitors), anticompetitive effects (whether in the form of a substantial lessening or prevention of competition or an adverse effect on competition) forms part of the elements of the reviewable practice itself.

A combination of contractual compellability, a reduced standard of proof, and a suboptimal system of investigating and adjudicating complaints, could have significant adverse effects not only for the administration of justice but also for the health services.

Compelling challenges include (1) the need for more extensive training for all health professionals on the adverse effects of excessive stress on the developing brain, as well as on the cardiovascular, immune, and metabolic regulatory systems (the technical report23 is a start); (2) the significant constraints on existing, office - based approaches to fully address the new morbidities effectively; (3) the relatively limited availability of evidence - based strategies, within the medical home and across the full array of existing early childhood service systems, that have been shown to reduce sources of toxic stress in the lives of young children or mitigate their adverse consequences35; and (4) the financial difficulties associated with the incorporation of evidence - based developmental strategies into the pediatric medical home.

What follows is a summary of the study design and the program's effects on the main outcomes measured nine years after random assignment, including any such outcomes for which no or adverse effects were found.4 All effects shown are statistically significant at the 0.05 level unless stated otherwise.