Sentences with phrase «significant adverse effects not»

A combination of contractual compellability, a reduced standard of proof, and a suboptimal system of investigating and adjudicating complaints, could have significant adverse effects not only for the administration of justice but also for the health services.

Not exact matches

As a result, there can be no assurance that a significant change in market interest rates will not have a material adverse effect on our net investment income.

Mass Audubon does not interfere with the natural water regime of wetlands on our properties to control mosquitoes, because of the significant adverse effects on wildlife and the natural system as a whole.

I don't know of any significant adverse effects, although erosion is beginning to be a problem in some places, since all the tourists are obliged to keep to the same trails.

Secondary prevention trials showed significant adverse effects of n - 6 LA on coronary heart disease mortality (1.84 (1.11 to 3.04); P = 0.02; web appendix, part 8).

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

(Although side effects other than myalgia weren't formally tracked, there were «no significant adverse events» in the patients taking red yeast rice, Dr. Becker says.)

The typical dosage of NAC given as an oral supplement in clinical trials is 600 mg b.i.d., although 200 mg t.i.d. has been shown to provide benefit in just 8 weeks.27 On the other hand, doses as high as 1 gram t.i.d. have been used in cystic fibrosis patients for 4 - 12 weeks with no adverse effects, and in AIDs patients, oral NAC doses up to 8 grams / day did not cause clinically significant adverse reactions.42 43 44 45 46 47

History of safe traditional use No case reports of significant adverse events with high probability of causality No significant adverse events in clinical trials No identified concerns for use during pregnancy or lactation No innately toxic constituents Toxicity associated with excessive use is not a basis for exclusion from this class Minor or self - limiting side effects are not bases for exclusion from this class»

While (green) tea consumption showed a small adverse affect on zinc bioavailability, the effect was not statistically significant.

(b) No person concerned with the testing process may declare a test cancelled based on a mistake in the process that does not have a significant adverse effect on the right of the employee to a fair and accurate test.

(b) No person concerned with the testing process may declare a test cancelled based on an error that does not have a significant adverse effect on the right of the employee to have a fair and accurate test.

The shift from print to digital books will not have adverse effects on the books of bestselling authors and those with significant platforms.

I buy TLI's argument that adverse - selection means folk who knew they only had a short life - expectancy will not have sold their policies, (hence my analysis is over-pessimistic) but am surprised this effect still persists after 6 + years (no significant turn up in mortality - rates pa towards those appropriate for their age so far).

Generally, though not always, your creditors will freeze the interest and penalties on your debts so that your reducing your monthly payment doesn't have significant adverse effects in the long run on the amount you need to pay back.

The therapeutic dotential of dietary precursor modulation by a fish - oil - supplemented diet (n - 3 fatty acids), such as eicosapentaenoic acid (C20: 5,n - 3) and docosahexaenoic acid (C22: 6,n - 3) in the therapy of ulcerative colitis has been shown to result in a 35 % to 50 % decrease in neutrophil production of LTB4.28 Significant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fSignificant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fsignificant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fatty acids.

Adverse effects on seabirds, fish and marine mammals are not believed to be significant, Faulkner said.

The Joint Panel concludes that the project is not likely to result in significant adverse environmental effects, provided that the recommendations and mitigation measures proposed by the Joint Panel are implemented.»

EPA's attempt to regulate emissions of carbon dioxide would also be a disaster if the Trump Administration allows the Obama regulations to be implemented since CO2 is not a pollutant, does not have a significant effect on global temperatures, and would have had huge adverse effects on the economy, on plants, and on poor people for no purpose.

He held that in making this judgment, a competent authority is not obliged to disregard any measures incorporated into the proposal which are designed to avoid or mitigate adverse habitat effects, observing that it would be «ludicrous» for a decision maker to have to disaggregate the different elements of the package, or require an appropriate assessment on the basis that the proposals (considered without the mitigating measures) would be likely to have a significant adverse effect, only for the package to have to be reassembled when carrying out the appropriate assessment.