Sentences with phrase «significant adverse effects of»

Raincoast Conservation Foundation and Living Oceans Society argued that the NEB and Cabinet failed to comply with the statutory requirements of the Species at Risk Act (SARA) with respect to the significant adverse effects of the Project on southern resident killer whales and their critical habitat.

Secondary prevention trials showed significant adverse effects of n - 6 LA on coronary heart disease mortality (1.84 (1.11 to 3.04); P = 0.02; web appendix, part 8).

We find no significant adverse effect of refugees on the educational outcomes of incumbent students including test scores, disciplinary incidents, and student mobility across schools.

Not exact matches

The Panel found that, «the likelihood of significant adverse environmental effects resulting from project malfunctions or accidents is very low,» but they did allow that a spill would involve significant adverse environmental effects.

The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations.

As a result, political instability, labor strikes, natural disasters or other events resulting in the disruption of trade or transportation from other countries or the imposition of additional regulations relating to duties upon imports could cause significant delays or interruptions in the supply of our merchandise or increase our costs, either of which could have an adverse effect on our business.

There are other aspects of the NGP Report that merit further discussion, including its approach to adaptive management (we now have three different JRP reports in as many years that take different views on the extent to which AM can be relied upon in making a determination as to the likelihood of significant adverse environmental effects under CEAA), the precautionary principle, species at risk and Aboriginal consultation.

The Governor in Council accepted the panel's recommendations that the pipeline will have significant adverse environmental effects to populations of woodland caribou and grizzly bears, but that these effects are justified in the circumstances.

These developments, or the perception that any of them could occur, have had and may continue to have a significant adverse effect on global economic conditions and the stability of global financial markets, and could significantly reduce global market liquidity and restrict the ability of key market participants to operate in certain financial markets.

In addition, there are proposals for tax legislation that have been introduced or that are being considered that could have a significant adverse effect on our tax rate, the carrying value of deferred tax assets, or our deferred tax liabilities.

Any of these factors could have a significant adverse effect on our business, financial condition, results of operations, and prospects.

HAZELTON — A federal environmental assessment report that concluded the proposed New Prosperity open - pit mine would have significant adverse effects for the Tsilhqot» in is a condemnation of the B.C. Liberals approach to Aboriginal rights and title, says Stikine MLA Doug...

Mass Audubon does not interfere with the natural water regime of wetlands on our properties to control mosquitoes, because of the significant adverse effects on wildlife and the natural system as a whole.

President Akufo - Addo was confident that these measures will enable the country attain a significant level of self - reliance, promote industrialisation and provide adequate cushion against the adverse effects of price shocks.

«Infertility is becoming a significant public health issue because of unexpected adverse effects on the health and quality of life and heavy expenditures on the health system,» said Dr. Jin - Young Min, the study's co-author.

«What I found surprising was that one needs rather larger velocities, a per cent of the speed of light in a vacuum, to see significant adverse effects,» he says.

«No significant safety concerns or dose - dependent adverse side effects of AVI - 7288 were reported with respect to any safety end point evaluated,» said Michael Wong, M.D., senior medical director for infectious diseases at Sarepta.

According to Bonn - Miller, a number of products also contained a significant amount of THC — the chemical compound in cannabis responsible for making a person feel «high» — which has been shown cause cognitive impairment and other adverse health effects.

I don't know of any significant adverse effects, although erosion is beginning to be a problem in some places, since all the tourists are obliged to keep to the same trails.

In the category «side effects,» significant effects were shown in favour of brivaracetam (for serious adverse events and some specific adverse events, such as dizziness or eye disorders).

The only results released by the study's sponsor, Geron of Menlo Park, Calif., indicate that neither patient has suffered any significant adverse effects.

For many medications, inherited differences in patients» ability to metabolize, transport, and eliminate drugs and in the characteristics of drug targets and receptors are significant determinants of therapeutic or adverse effects of medications.

Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96

A small clinical trial showed a statistically significant improvement in atopic dermatitis (eczema) lesions after application of Manuka honey applied overnight after 1 week without any adverse effects.

The EPA publishes a reference dose (RFD) for silver which is an estimate of daily exposure to the entire population that is unlikely to be associated with a significant risk of adverse effects over a lifetime.

Skeptics might counter that this could be largely the placebo affect, but in the absence of any adverse effects and considering that placebo works a significant percentage of the time, I'd still consider it worth a try.

No fewer than 28 clinical trials in humans have shown that pantethine produces significant positive changes in triglycerides, LDL cholesterol, and VLDL, along with increases in HDL cholesterol.5 In all of these trials, virtually no adverse effects were noted.

The typical dosage of NAC given as an oral supplement in clinical trials is 600 mg b.i.d., although 200 mg t.i.d. has been shown to provide benefit in just 8 weeks.27 On the other hand, doses as high as 1 gram t.i.d. have been used in cystic fibrosis patients for 4 - 12 weeks with no adverse effects, and in AIDs patients, oral NAC doses up to 8 grams / day did not cause clinically significant adverse reactions.42 43 44 45 46 47

History of safe traditional use No case reports of significant adverse events with high probability of causality No significant adverse events in clinical trials No identified concerns for use during pregnancy or lactation No innately toxic constituents Toxicity associated with excessive use is not a basis for exclusion from this class Minor or self - limiting side effects are not bases for exclusion from this class»

As with any phentermine weight loss medication, Adipex P is effective when accompanied by plenty of exercises, a reduced calorie intake, and a significant tolerance to the (sometimes) extremely adverse effects of the drug.

Therefore, it is important to appreciate that the many ultra-low carbohydrate diets that are now in vogue for so many in the nutritional community, while they may be beneficial for those individuals who have, for years, ingested a diet high in poor quality carbohydrates, can have an adverse effect on the gut when they are employed in excess for a significant period of time.

(b) No person concerned with the testing process may declare a test cancelled based on a mistake in the process that does not have a significant adverse effect on the right of the employee to a fair and accurate test.

(b) No person concerned with the testing process may declare a test cancelled based on an error that does not have a significant adverse effect on the right of the employee to have a fair and accurate test.

The shift from print to digital books will not have adverse effects on the books of bestselling authors and those with significant platforms.

Any significant decline in our investment income as a result of falling interest rates, decreased dividend payment rates or general market conditions would have an adverse effect on our net income and, as a result, on our stockholders» equity and our policyholders» surplus.

If the landlord is ultimately successful in its complaint, we may be liable for significant damages in connection with the alleged early termination of the lease and may lose assets related to the biopharmaceutical manufacturing facility we have constructed within the leased premises, which could have a material adverse effect on the our financial position, results of operations or cash flows.

On the other hand, those many influences listed can also have an adverse effect on your principal and even the smallest bit of unrest somewhere in the world can have a significant impact on your investment.

For pets, being overweight can have significant adverse effects on their health and quality of life, and leads to the premature death of millions each year.

The therapeutic dotential of dietary precursor modulation by a fish - oil - supplemented diet (n - 3 fatty acids), such as eicosapentaenoic acid (C20: 5,n - 3) and docosahexaenoic acid (C22: 6,n - 3) in the therapy of ulcerative colitis has been shown to result in a 35 % to 50 % decrease in neutrophil production of LTB4.28 Significant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fSignificant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fsignificant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fatty acids.

Further, adverse effects are amply documented and are far more significant to public health than any adverse effects of infectious diseases.

Interestingly, the paper «Climate Trends and Global food production since 1980» (Lobell, Schlenker, Costa - Roberts, in Sciencexpress, 5 May, Science 1204531) confirms my finding of the absence of climate change in the USA: «A notable exception to the [global] warming pattern is the United States, which produces c. 40 % of global maize and soybean and experienced a slight cooling over the period... the country with largest overall share of crop production (United States) showed no [adverse] effect due to the lack of significant climate trends».

This was significant, as this study was the first to find evidence of an adverse health effect in any mammal species from the consumption of GM foods.

The primary current problem is that the climate alarmists are creating enormous problems in the generation and use of reliable energy necessary for the development and even the continuation of modern civilization, with adverse effects on the economy, human welfare, and even the environment, all for no significant benefits to anyone except vendors of renewable energy facilities.

Recalling the concern reflected in the outcome document of the United Nations Conference on Sustainable Development, entitled «The future we want», 1 that the health of oceans and marine biodiversity are negatively affected by marine pollution, including marine debris, especially plastic, persistent organic pollutants, heavy metals and nitrogen - based compounds, from numerous marine and land - based sources, and the commitment to take action to significantly reduce the incidence and impacts of such pollution on marine ecosystems, Noting the international action being taken to promote the sound management of chemicals throughout their life cycle and waste in ways that lead to the prevention and minimization of significant adverse effects on human health and the environment, Recalling the Manila Declaration on Furthering the Implementation of the Global Programme of Action for the Protection of the Marine Environment from Land - based Activities adopted by the Third Intergovernmental Review Meeting on the Implementation of the Global Programme of Action for the Protection of the Marine Environment from Land - based Activities, which highlighted the relevance of the Honolulu Strategy and the Honolulu Commitment and recommended the establishment of a global partnership on marine litter, Taking note of the decisions adopted by the eleventh Conference of the Parties to the Convention on Biological Diversity on addressing the impacts of marine debris on marine and coastal biodiversity, Recalling that the General Assembly declared 2014 the International Year of Small Island Developing States and that such States have identified waste management among their priorities for action, Noting with concern the serious impact which marine litter, including plastics stemming from land and sea - based sources, can have on the marine environment, marine ecosystem services, marine natural resources, fisheries, tourism and the economy, as well as the potential risks to human health; 1.

KR asks the correct question finally, as to what we would do if human CO2 production was the cause of significant global warming with significant adverse effects.

On the contrary, I believe there should be freedom of energy use and selection as long as there are no significant adverse effects on others.

Yet no significant adverse environmental effects of fracking have been proved to date.

In addition, Article 9 states that the provision of scaled - up financial resources should aim to achieve a balance between adaptation and mitigation, taking into account country - driven strategies, and the priorities and needs of developing country Parties, especially those that are particularly vulnerable to the adverse effects of climate change and have significant capacity constraints, such as the least developed countries and small island developing States, considering the need for public and grant - based resources for adaptation.

EPA's attempt to regulate emissions of carbon dioxide would also be a disaster if the Trump Administration allows the Obama regulations to be implemented since CO2 is not a pollutant, does not have a significant effect on global temperatures, and would have had huge adverse effects on the economy, on plants, and on poor people for no purpose.

This was a very significant case for women's equality rights as it gave LEAF and its coalition partners an opportunity to elaborate on the key human rights concepts of adverse - effect discrimination and the duty to accommodate, as well as to argue against the idea of «reverse discrimination».