Using these orthogonal measures of cellular pathway analysis, we confirmed that HPP - 4382, in contrast to bardoxolone, did not induce
significant cellular stress at high doses as measured by HSPA6 expression and that the mechanism of HPP - 4382 activity does not appear dependent on NF - B as ICAM1 expression is not induced by HPP - 4382 (data not shown).
Findings based on this new technology are likely to have a
significant impact on basic
cellular research and increase our knowledge of how cells work and respond to
stresses, such as exposure to contamination.