Sentences with phrase «significant change in cell»

By contrast, no significant changes in cell proliferation were seen following transient transfection with control 4E - BP1 siRNA.

Not exact matches

In these canine cells we induced a morphological change similar to what happens in cancer progression and we have seen displayed significant alterations in the modulation of genes, called epigenetic lesions,» says Manel EstelleIn these canine cells we induced a morphological change similar to what happens in cancer progression and we have seen displayed significant alterations in the modulation of genes, called epigenetic lesions,» says Manel Estellein cancer progression and we have seen displayed significant alterations in the modulation of genes, called epigenetic lesions,» says Manel Estellein the modulation of genes, called epigenetic lesions,» says Manel Esteller.

The new compound, Corin, specifically targets these epigenetic changes in cells and could therefore provide significant improvements in patients without unwanted side effects.

But something more significant than the changes in cell number is also going on.

In collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changeIn collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changein skin cells differed among the Esrp knockouts and found hundreds of significant changes.

Fifty - three of the brain cells showed significant changes in activity as the coils rotated, reacting to field strength and polarity.

The team found significant changes in gene expression after light exposure in all cell types in the visual cortex — both neurons and, unexpectedly, nonneuronal cells such as astrocytes, macrophages and muscle cells that line blood vessels in the brain.

«After a year of sound deprivation, we observed dramatic changes in the inner ear — notably, a significant loss of the synaptic connections through which the sensory cells send their electrical signals to the brain,» Dr. Maison said.

Based on analyses of over 600 drug and breast cancer cell pairings, researchers showed that, for some cells, drug exposure can cause significant changes in gene expression — indicating the successful action of a drug on its target — without affecting cell growth or survival.

In these cases, drug exposure caused significant changes in tumor cells» gene expression profile but had no lasting physical effecIn these cases, drug exposure caused significant changes in tumor cells» gene expression profile but had no lasting physical effecin tumor cells» gene expression profile but had no lasting physical effect.

«Since that time, Lorenz has made a significant number of transformative contributions and developed protocols that have fundamentally changed the way we create stem cells in the lab,» said Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease.

«Cell - nanoparticle interactions can produce significant change in cellular behaviour that we can observe using this technique,» explains Irtisha Singh, who is one of the senior authors of this study.

We found significant differences in overall cellular composition between pre - and post-mortem blood samples (p < 0.001), the most notable changes induced by death being an increase in resting NK cells and CD8 T - cells, and a substantial reduction in neutrophils (Fig. 7a).

The critical secondary endpoint of the change in retinal ganglion cell macular volume measured from baseline to week 48 demonstrated a statistically significant difference (p = 0.0189) between all GS010 - treated eyes and all sham - treated eyes, with untreated eyes losing 0.038 cubic mm of macular ganglion cell volume while treated eyes preserved their ganglion cell volume -LRB--0.003 cubic mm).

This effect on growth inhibition was not due to alterations in cell cycle (Supplemental Fig. 5) nor a significant increase in the apoptotic cell populations, suggesting that RIPK2 inhibition of proliferation is independent of cell cycle or apoptotic changes.

Second, in components of the medullary 5 - HT system that contain 5 - HT cell bodies (ie, PGCL, gigantocellularis, and intermediate reticular zone), there was a significant age × diagnosis interaction with decreased receptor binding with increasing age in SIDS cases but no change in controls (Figure 2A).

To determine the length of time required for the two states to interconvert we purified populations V+S + and V − S + cells and examined the extent to which the original distribution was re-established and observed significant changes in both populations within 24 h of plating (Figure 7B).

Our data suggest that changes in the expression of genes associated with drug resistance and cancer cell «stemness», induced by treatment with MIA - 602, lead to a significant reduction in the efflux capacity of drug resistant cells.

Pair-wise comparisons (FDR < 0.05, > 1.5-fold expression levels) were performed between the following populations of cells to reveal non-redundant, significant changes in gene expression.

Because of small sample size, the changes in tumor - initiating cell number were not significant (P > 0.05), but these data are supportive of the in vitro findings and suggest that hypoxia may have a positive effect on the tumor - initiating cell population in ER - α — positive breast cancers and a negative effect in ER - α — negative tumors.

No significant differences were seen between the normoxic and hypoxic anoikis - resistant populations collected from MCF7 cells and a single significant gene change (PIP) was seen in T47D (Table 1) suggesting that the CSC - enriched population remains virtually unchanged following hypoxic culture and the increase in MFC, HFC, and tumor initiating cells is, therefore, due to expansion of the population, perhaps by increased symmetric self - renewal of the CSC or de-differentiation of early progenitor cells, rather than simply the acquisition of anoikis resistance in non-CSC.

Flow cytometry revealed no significant changes in NK cells and CD8 + T cell frequencies in the spleens of the treated mice, suggesting that activation of existing cells was responsible for killing the HIV - LucR - infected cells.

Significant changes in gene expression between anoikis - resistant and total population cells are shown in Table 1.

These cells could be expanded for at least 20 passages (2 ∧ 20 or at least a million-fold expansion) and differentiated into endothelial cells without any significant change in their morphology (Figure S4).

This means that cells or urine or sweat can show significant swings in pH that greatly affect function and health status while the blood pH has minimal change.

(6)(12) Since genetic changes occur within cells only after the breakdown of efficient metabolism, (7)(8)(9)(10)(11) it is unlikely that genetics play any kind of significant role in headache occurrance, but the environmental theory is likely.

There are various types of technologies that can play significant roles in mitigating climate change, including energy efficiency improvements throughout the energy system (especially at the end use side); solar, wind, nuclear fission and fusion and geothermal, biomass and clean fossil technologies, including carbon capture and storage; energy from waste; hydrogen production from non-fossil energy sources and fuel cells (Pacala and Socolow, 2004; IEA, 2006b).

The question then is whether any such changes produce an effect that is significant in changing the intensity of the polar high pressure cells.

Although controlling the effect of cell type did not reduce the direct effect of parenting on health or result in a significant IE of protective parenting on young - adult health, this effect does illustrate the potential for protective parenting to influence future health - relevant processes indirectly by changing cell type.