Sentences with phrase «significant clinical activity»

Professor Josep Tabernero, a member of the scientific committee for the EORTC - NCI - AACR Symposium and head of the medical oncology department at Vall d'Hebron University Hospital and director of the Vall d'Hebron Institute of Oncology, Barcelona, Spain, commented: «These are encouraging results, which show that galeterone has significant clinical activity in men with castration - resistant prostate cancer that fails to respond to other drugs.

Not exact matches

The finding, though preliminary, is significant in part because «the brain stem is really involved in autonomic activities — breathing, heart rate, staying awake — so this is evidence that there's something core and basic, this connection between aggression and autism,» said coauthor and BYU clinical psychology Ph.D. student Kevin Stephenson.

Understanding the process of activity - dependent circuit formation and regulation will have a significant impact on the basic and clinical scientific communities.

However, ADCs that use derivatives of calicheamicin, which promotes double - stranded DNA breaks, such as GO and inotuzumab ozogamicin, 40,41 have limited activity in cells with high multidrug resistance protein activity, a phenotype found in a significant fraction of AML patients.42 Another ADC, SGN - CD123A, comprising an engineered form of the CD123 - targeting 7G3 antibody conjugated to a synthetic pyrrolobenzodiazepine dimer, which acts via DNA crosslinking, has entered clinical trials after showing robust activity in preclinical models of AML, including those with multidrug resistance.33

My experience in clinical practice allows me to assist with goal directed activities and work to achieve significant changes.