The team found deep conservation of certain processes that likely reflects similar underlying regulatory processes between mouse and man, but there were also
significant differences in gene expression during kidney development, as well as in the timing, scale, organization, and molecular profile of key cell types and cell structures.
For example, the nuclei in the centers of the mutant organoids moved more slowly, and we saw
significant differences in gene expression.»
Not exact matches
In the healthy weight subjects, the difference in gene expressions were not significan
In the healthy weight subjects, the
difference in gene expressions were not significan
in gene expressions were not
significant.
Among older sets of twins, however,
significant differences in the
gene -
expression portraits were apparent for 35 percent of the study group.
****,
significant differences in dosing regimen on the
expression of each membrane transporter
gene were observed as assessed by two - way ANOVA analysis, P <.0001; ***, significantly different by ANOVA, P <.001; **,
significant differences by ANOVA, P <.01; *,
significant differences by ANOVA, P <.1.
All six
genes could be validated, and showed
significant expression differences between unrelated patients with diabetes and nondiabetic subjects
in the same direction as the discordant twins (Fig. 1B and D).
Others were unanticipated, including
significant differences in expression levels among
genes involved
in fundamental cellular processes such as ribosomal biogenesis, transfer RNA processing, and Notch - signaling — part of a complex system of communication that governs basic cellular activities and coordinates cell actions.
The
difference in gene expressions were not
significant in the normal weight individuals.