Sentences with phrase «significant gene copy»
About 90 % of solid tumors display whole - chromosome aneuploidy, while many tumors with diploid karyotypes nonetheless harbor segmental or arm - length aneuploidies that also result in significant gene copy number alterations.
https://www.cshl.edu/ Not exact matches
Tumours in these mice grew 50 per cent more slowly than those in healthy mice, indicating that one extra copy of the gene has a significant effect on tumour growth (Nature, DOI: 10.1038 / nature08062).
However, simultaneously removing a copy of both genes revealed significant synergy between them.
By performing a meta - analysis of rare coding variants in whole - exome sequences from 4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and copy number variants from 6,882 cases and 11,255 controls, we show that individuals with schizophrenia carry a significant burden of rare, damaging variants in 3,488 genes previously identified as having a near - complete depletion of loss - of - function variants.
Dogs with two copies of the merle gene usually have multiple and significant problems with the eyes.
I agree it's significant that dogs have between four and 30 copies of the amylase gene, and this wide range would indicate that some dogs are much less able to handle starch than others.