Sentences with phrase «significant gene expression changes»

Not exact matches

Utilizing this very sensitive technique they were able to demonstrate significant changes in the expression of over 4000 genes.

In collaboration with Yi Xing from UCLA, the team catalogued and analyzed how gene expression patterns in skin cells differed among the Esrp knockouts and found hundreds of significant changes.

Based on the CT based anatomical observations in probainognathians, it appears that the MSX2 gene underwent a significant change in its expression 240 - 246 million years ago and triggered the evolution of many typical mammalian traits including hair and whiskers, an enlarged cerebellum, complete ossification of the skull roof, and more importantly, the mammary glands, that define mammals today.

But the researchers found no significant changes in the expression of genes known to be involved in calcification from prior studies comparing strains with dramatically different calcification levels.

When Bordenstein and Brucker compared gene expression patterns in normal and microbe - free offspring, they found significant changes in many of the genes involved in the immune response (Science, doi.org/m87).

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

The team found significant changes in gene expression after light exposure in all cell types in the visual cortex — both neurons and, unexpectedly, nonneuronal cells such as astrocytes, macrophages and muscle cells that line blood vessels in the brain.

Mao's study examined mitochondria - associated gene expression in the mouse eye tissue and found significant changes in several genes involved in oxidative stress response.

«We observed small but significant changes in the gene expressions between normal and diabetic corneas,» said Mehrnoosh Saghizadeh Ghiam, PhD, assistant professor of biomedical sciences and neurosurgery, a researcher in the Regenerative Medicine Institute Eye Program and the lead author of the study published in the journal PLOS ONE.

Based on analyses of over 600 drug and breast cancer cell pairings, researchers showed that, for some cells, drug exposure can cause significant changes in gene expression — indicating the successful action of a drug on its target — without affecting cell growth or survival.

The most significant changes occurred in a gene called RbAp48, whose expression declined steadily with aging across the study subjects.

In these cases, drug exposure caused significant changes in tumor cells» gene expression profile but had no lasting physical effect.

To identify genes that changed expression depending on PMI, we used the five PMI intervals also used by the GTEx Biospecimen Methodological Study (BMS) 21, and asked which genes had a significant and noticeable change between two consecutive time intervals (> 2-fold change and Wilcoxon test p < 0.05, see Methods and Supplementary Note 2).

Proteomic analysis to profile protein abundance resulted in the identification and relative quantification for 912 proteins with two or more unique peptides and 86 proteins with significant abundance changes after treatment with the neurotoxins, while microarray analyses to profile gene expression revealed 181 genes with significant changes in mRNA after treatment.

Our data suggest that changes in the expression of genes associated with drug resistance and cancer cell «stemness», induced by treatment with MIA - 602, lead to a significant reduction in the efflux capacity of drug resistant cells.

Pair-wise comparisons (FDR < 0.05, > 1.5-fold expression levels) were performed between the following populations of cells to reveal non-redundant, significant changes in gene expression.

Significant changes in gene expression between anoikis - resistant and total population cells are shown in Table 1.