Sentences with phrase «significant lack of activity»

The judge did accept that there was a «significant lack of activity» by the claimants between March 2003 and February 2005.

Not exact matches

The recent improvement in start - up activity despite a relatively healthy labour market indicates that a significant number of new entrepreneurs chose self - employment as a career rather than being forced to open a business due to a lack of other employment opportunities.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

Lack of sun exposure and reduced physical activity are significant contributors to wintertime depression.

The decrease in overall activity levels is a significant culprit as is a lack of regular balanced meals during the summer months for many children.

NUT Cymru secretary David Evans added that there were «significant barriers» to promoting better collaboration between schools or better access to professional development «from a lack of high quality training provision, a lack of financial resources to release teachers or workload pressures making non-classroom activity almost impossible».

Furthermore, a lack of activity can cause your dog to gain weight and be obese, which will, in time, be the cause of significant health problems in the dog.

For instance, the warming that began in the early 20th century (1925 - 1944) is consistent with natural variability of the climate system (including a generalized lack of significant volcanic activity, which has a cooling effect), solar forcing, and initial forcing from greenhouse gases.

All of these enviro - whackpot prognosticators of a global warming Apocalypse lack the intellectual curiosity to even wonder how there can be so much evidence - backed, statistically significant research showing that all past and historical global warming is completely explained by ENSO effects and other natural activity.

Evidence of financial abuse includes significant withdrawals from accounts or changes in the elder's financial condition, suspicious changes in wills, powers of attorney and other documents, unpaid bills or lack of medical care, unnecessary services, goods, or subscriptions, and other irregular activities.

They are also unhappy that the director of public prosecutions has to give consent to any prosecutions, that the legislation lacks extra-territorial bite, and that the test of senior management failure is too restricted — namely that «only those persons who play a significant role in decisions or in the actual managing or organising of the whole or a substantial part of those activities» can be the catalyst for the offence.

People with depression may experience a lack of interest and pleasure in daily activities, significant weight loss or gain, insomnia or excessive sleeping, lack of energy, inability to concentrate, feelings of worthlessness or excessive guilt and recurrent thoughts of death or suicide.