Using a flexible mouse model, her team set out to determine whether anything could be done to restore memory «after
a significant number of neurons are lost in the brain.»
«More likely, those long - term memories become inaccessible after
a significant number of neurons are lost.»
Not exact matches
«Although running induces both substantial changes in
number and morphology
of young
neurons as well as
significant changes in learning behavior, this does not prove a causal relationship,» noted Professor Bischofberger, «Nevertheless, our results, together with previous findings, suggest that the enhanced pattern separation during memory testing is most likely mediated via running - induced increase in adult neurogenesis.»
«Rapid access to large quantities
of neurons will be useful for testing a
significant number of pharmacological drugs in order to identify those capable
of preventing the death
of motor
neurons,» concludes Cécile Martinat.
While Htt null KO mice do not survive to birth (Duyao et al., 1995; Nasir et al., 1995; Zeitlin et al., 1995), mice expressing a 50 % reduction
of endogenous htt levels reveal cognitive and motor deficits (Nasir et al., 1995) and
significant decreases in the
number of neurons in globus pallidus and subthalamic nucleus (O'Kusky et al., 1999).
(A) hGDABMP transplantation led to
significant increases in
numbers of NeuN +
neurons counted in a 1.8 mm length
of spinal cord encompassing the injury site.
Significant increases in
neuron numbers were not observed in lamina 4, 5, 6 adjacent to injury centers, despite rescue
of neurons more distal to the zone
of injury; an outcome most likely due to
neuron loss resulting from direct trauma to these laminae at time
of injury.
(B) Analysis
of neuron survival within laminae immediately adjacent to the site
of injury shows that hGDABMP transplantation promoted
significant protection
of neurons when all laminae were considered (4 to 9), with the most robust increases in
neuron numbers in intermediate (7) and ventral (8 and 9) gray matter laminae.
There were no
significant differences in the
number of doublecortin - positive
neurons between genotypes, nor was there a
significant interaction
of genotype and exercise.
The
numbers of neurons in our brains begin to decrease at the age
of thirty and some neurological diseases can result from
significant loss.