Sentences with phrase «significant numbers of cells»

As seen in cells dissected from colonies, significant numbers of cells coexpressed lineage specific markers along with pluripotency genes.

Often the feasibility of using stem cells for regenerative therapies is limited by two factors: obtaining a significant number of cells and doing so in a relatively noninvasive manner.

If a significant number of cells that produce insulin are destroyed, diabetes mellitus can result and insulin therapy may be needed.

Not exact matches

Once a significant number of islet cells are destroyed, you'll produce little or no insulin.

«It was once believed that we lose significant numbers of nerve cells as we age, particularly in the areas important for learning and memory,» she says.

«These new results are significant because they represent the discovery of a number of more potent variations of the natural product as cytotoxic agents against cancer cells,» Nicolaou said.

These signals come in bursts, so the number and spacing of the electrical impulses from climbing fiber to Purkinje cell might be significant.

Recent studies highlighted significant differences between these two types of stem cells, although only a limited number of cell lines of different origins were analyzed.

«We were able to show that a significant number of these adenomas carry a mutation in a gene that is involved in controlling cell proliferation and differentiation,» Calebiro further explained.

Adipose tissue within muscle contained significant numbers of F4 / 80 + macrophages, and the percentage of F4 / 80 + cells within this adipose tissue was markedly increased in obese mice compared with lean mice (41 % ± 4 % of macrophages vs. 12 % ± 2 % of macrophages, respectively; P < 0.005, mean ± SD)(Figure 4).

They observed a significant decrease in the number of proliferating stem cells in the brains of HIV / gp120 - mice compared with similar tissue from normal, wild - type mice.

«Since that time, Lorenz has made a significant number of transformative contributions and developed protocols that have fundamentally changed the way we create stem cells in the lab,» said Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease.

Several studies suggest that a significant number of corneal allografts undergo rejection in the absence of CD4 + T cells.

But efforts to develop adoptive T cell therapies for solid tumors have hit upon a number of challenges; the only gene therapies to show significant benefit for patients have been in liquid tumors — forms of leukemia and lymphoma.

γH2Ax assay revealed a significant increase (p < 0.05) in number of foci / nuclei in siTRF2 cells compared to scrambled (Fig 3d and 3e).

Experiments were performed to confirm that a significant number of corneal allografts underwent rejection in the absence of CD4 + T cells.

With increasing concentration, a significant 2-fold increase in number of γH2Ax foci (green dots) in siTRF2 silenced HCT116 cells was observed compared to those formed in scrambled transfected HCT116 cells (p < 0.01)(Fig 3d and 3e).

Immunization with gp33 - loaded DCs led to the development of significant numbers of CD8 + T cells capable of making rapid IFN - γ responses to gp33 restimulation, consistent with a memory response, which was absent in control immunized mice (Fig. 1A).

However, these approaches have significant drawbacks, including inconsistency; limitations in the number of simultaneous labels because of spectral overlap; and necessary pertur - bations of the experiment, such as fixing the cells, to generate the measurement.

Researchers at Columbia University have made a significant step toward breaking the so - called «color barrier» of light microscopy for biological systems, allowing for much more comprehensive, system - wide labeling and imaging of a greater number of biomolecules in living cells and tissues than is currently attainable.

hASC treatment also mediated a significant preservation of insulin staining and β cell mass, boosted β cell number, and also induced β cell proliferation, while hASC - conditioned medium (hASC - CM) was also able to support mouse islet survival after dissociation in vitro.

They reported in a recent study in PLoS ONE using human cells that the flavones not only killed a significant number of bacteria, but also had a synergy against them in the presence of antibiotics.

He is best known for his discovery that copy - number variation — a state in which cells have an abnormal number of DNA sections, sometimes associated with susceptibility or resistance to disease — is widespread and significant in the human genome.

Because of small sample size, the changes in tumor - initiating cell number were not significant (P > 0.05), but these data are supportive of the in vitro findings and suggest that hypoxia may have a positive effect on the tumor - initiating cell population in ER - α — positive breast cancers and a negative effect in ER - α — negative tumors.

Interestingly, when we looked at the splenocytes in these mice and compared them to controls, we were not able to detect a significant difference in the numbers of Tregs, suggesting that in the transplant model, Tregs may be within the graft - infiltrating population where they could regulate infiltrating host T cells.

Despite the reduced levels of insulin released after arsenic exposure, however, the researchers found no significant differences in inflammation of the pancreas or the number of insulin - producing cells (beta cells) in the pancreas that are known to promote the development of diabetes.

With a minimal 2 - hour therapy period, this study found that castor oil packs produced a «significant» temporary increase in the number of T - 11 cells that increased over a 7 hour period following treatment and then returned to normal levels within 24 hours later.

Not only does forest bathing enhance NK cell activity, but it also increases their number, and for a significant length of time: the positive effects lasted for more than a week after the forest excursion.

One study, focusing on castor oil's effects on our lymphatic system, found a «significant» increase in the number of T - 11 cells within patients after performing a castor oil treatment.

Dietary fibre modifications that are low in fat and glucose reduce the risk for AD by not only effecting cell membranes and nutrient sensing G coupled receptors but also by regulating number of nuclear receptors such as histone deacetylases (HDAC) and peroxisome proliferator activated receptors (PPAR) that control glucose, fatty acids and cholesterol and have significant effects on the brain cholesterol homeostasis and amyloidosis.

Another significant problem is connected with the fact that the cloned specimens live for short time, as the used initial cells already have a «memory» corresponding to the number of years of an organism.

Our preliminary results indicate that while the addition of CpG may induce a mild increase in the number of CD40 - B cells generated we have not identified any significant increase in expression of B cell surface molecules over and above a negative GpC control.

• Complete blood cell count (CBC)- This is a blood test that looks at the numbers of white and red blood cells and platelets as well as the types and abnormalities of blood cells A CBC may be indicated if the patient is not in good physical condition because it can detect signs of infection and anemia which may be significant in the treatment regimen.

For example if we replace significant numbers of internal combustion engines with fuel cells then we trade carbon dioxide emmisions for water vapor.

We see disproportionately high numbers of men and women held in police cells, incarcerated in gaols, and significant numbers passing away from violence, illness or a combination of both while detained by the state this year.