Sentences with phrase «significant role in the disease»
Even though Alzheimer's is classified as a degenerative disease, the immune system plays a significant role in the disease process.
https://www.mindbodygreen.com/ Not exact matches
The advent of rice varieties bearing genes with resistance to the disease has changed the perception about the disease: the incorporation of host - plant resistance genes in rice varieties, their adoption and deployment in the world's main rice - producing environments is probably one of the most significant evidences of the role of plant pathology in agricultural development.
Ali has a passion to create public awareness regarding the significant role diet plays in our overall health and believes everything we put in our body can contribute towards optimal health or dysfunction and disease.
Human breast milk that is frozen or stored for longer than 48 hours loses a significant amount of its antioxidant content, making it less able to help infants fight off free radicals that play a role in allowing infections and other diseases.
Packed with disease - fighting components, breast milk plays a significant role in boosting your baby's immunity to offer protection from several illnesses.
Packed with disease - fighting components, breast milk plays a significant role in boosting your baby's immunity to offer protection from several illnesses.Some mothers may want -LSB-...]
DNMT3A is among the most frequently mutated genes in an aggressive type of leukemia, and it plays a significant role in how this disease develops.
And in previous work, Poinar and his wife, Roberta, implicated malaria and the evolution of blood - sucking insects as disease vectors that could have played a significant role in the extinction of the dinosaurs.
If SOCE operates similarly in mammalian cells, it might have some role to play in diseases where dopamine plays a significant role such as Parkinson's, Attention Deficit Syndromes (ADS) and even schizophrenia.
Firearms play a significant role in both suicide and homicide, accounting for slightly more than half of all suicide deaths and two - thirds of homicide deaths, according to 2009 data from the 16 - state National Violent Death Reporting System, which is run by the U.S. Centers for Disease Control and Prevention.
«Not only does it add significant weight to the growing body of evidence that PCV prevents disease, but it suggests that vaccines may have a role to play in the fight against antibiotic resistance.»
Scientists from Trinity College Dublin have made a significant breakthrough in understanding the regulation of immune cells that play a pivotal role in allergic diseases such as asthma and eczema.
Research findings indicate that abnormal CaSR function and / or abundance play a significant role in the development or progression of several non-communicable diseases (or NCDs) such as Alzheimer's disease, cardiovascular diseases, diabetes, cancer, and degenerative muscle loss.
Astrocytes, the supporting cells of the brain, could play a significant role in the pathogenesis of Alzheimer's disease (AD), according to a new study from the University of Eastern Finland.
«High levels of the cell signalling protein TNF have been reported in JDM patients with a long disease course, suggesting this immune cell regulator may play a significant role in refractory disease,» said Dr Raquel Campanilho - Marques of the Institute of Child Health, University College London, UK.
A human protein known as prohibitin may play a significant role in infection of the nervous system by EV71, one of several viruses that can cause hand, foot, and mouth disease.
This discovery provides a significant opportunity not only to enhance our understanding of how miRNAs regulate a variety of biological processes in an important model species for studying human diseases, but can lead to further, similar research into the role that miRNAs play in animal domestication.
«Stem cell biology has become one of the most exciting and promising areas of research, with real impact on how we treat human disease,» said Gladstone President R. Sanders Williams, MD. «With its meetings and journals, ISSCR has developed a significant role in communicating and promoting groundbreaking advances in the field.
Given its significant role in pathogenesis of cancer and cardiovascular diseases, CD47 signalling has been heavily investigated for new targeted therapeutics.
«Microbes play a significant role in the health of the digestive tract and many digestive diseases result when the microbial environment is out of balance,» said Griffin P. Rodgers, M.D., M.A.C.P., director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and co-chair of the Human Microbiome Project's Implementation Group.
The SDF - 1 / CXCR4 axis is gaining significant attention mainly due to its important roles in pathological processes, such as HIV entry, tumor metastasis, cell trafficking in autoimmune diseases and inflammatory conditions [10].
The study, published July 21, 2016, in Scientific Reports, also showed significant changes in the gut microbiome after antibiotic treatment, suggesting the composition and diversity of bacteria in the gut play an important role in regulating immune system activity that impacts progression of Alzheimer's disease.
Importantly, these mice still had significant improvement in survival compared with immunized mice receiving placebo treatment (average survival 9 d), indicating that IFN - γ continues to play an important role in mortality in enhanced HLH disease.
In the summer of 2010, we posted an entry about a significant advance in basic mitochondrial biology that held within it a tantalizing promise: a potentially new approach to obviating the problem of age - related accumulation of mutations in mitochondrial DNA (mtDNA), which are widely suspected to play an important role in the age - related rise in oxidative stress, Parkinson's disease, and age - related muscle degeneratioIn the summer of 2010, we posted an entry about a significant advance in basic mitochondrial biology that held within it a tantalizing promise: a potentially new approach to obviating the problem of age - related accumulation of mutations in mitochondrial DNA (mtDNA), which are widely suspected to play an important role in the age - related rise in oxidative stress, Parkinson's disease, and age - related muscle degeneratioin basic mitochondrial biology that held within it a tantalizing promise: a potentially new approach to obviating the problem of age - related accumulation of mutations in mitochondrial DNA (mtDNA), which are widely suspected to play an important role in the age - related rise in oxidative stress, Parkinson's disease, and age - related muscle degeneratioin mitochondrial DNA (mtDNA), which are widely suspected to play an important role in the age - related rise in oxidative stress, Parkinson's disease, and age - related muscle degeneratioin the age - related rise in oxidative stress, Parkinson's disease, and age - related muscle degeneratioin oxidative stress, Parkinson's disease, and age - related muscle degeneration.
There is increasing evidence that rare and unique mutations have a significant role in the etiology of many diseases such as autism, congenital heart disease, and cancer.
Although the results were not statistically significant, certain SNPs emerged that have been suggested to play a role in other studies of septic perianal Crohn's disease.
The short form of the serotonin transporter gene promoter does not explain autism, insists Dr. Cook, who heads a nationwide consortium of researchers looking for the genetic underpinnings of this disease, but it does appear to play a significant role, perhaps in concert with other abnormalities which we've not yet uncovered.
The researchers say using the CCR5 mutant donation and / or the presence of graft versus host disease, which results in the elimination of HIV - positive reservoir cells that survive irradiation, played a significant role in curing the Berlin patient.
In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.in AML and breast cancer patients.10
Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96
The advent of rice varieties bearing genes with resistance to the disease has changed the perception about the disease: the incorporation of host - plant resistance genes in rice varieties, their adoption and deployment in the world's main rice - producing environments is probably one of the most significant evidences of the role of plant pathology in agricultural development.
«It's also believed that sleep effects cholesterol levels, which plays a significant role in heart disease.»
A recent study found that polyphenols from foods such as blueberries, coffee, and extra-virgin olive oil play a significant role in the prevention of degenerative diseases by improving your microbiome environment.
A recent study found that nutrients called polyphenols (found in many of the foods we focus on in the elimination diet) play a significant role in the prevention of degenerative diseases by improving your microbiome environment.
It's often suspected that a chronic overgrowth in the gut is frequently misdiagnosed as diseases like chronic fatigue syndrome and that it might play a significant role in inflammatory bowel diseases like ulcerative colitis.
Ajwa, types of dates that is only cultivated in Saudi Arabia / Al - Madinah Al - Munawara and have significant value in several types of diseases cure and also show protective role in hepatic [liver] toxicity.
GSH is unique in that it plays a crucial role in protecting us from a wide variety of substances that can do significant damage to our tissues Those suffering from many chronic diseases such as AIDS, advanced diabetes, and cancer have very low levels, hence the obvious importance in human health and why researchers continue to study it.
Researchers found the role sunlight plays in preventing cardiovascular disease is very significant — they discovered cardiovascular disease is higher during winter and in countries far away from the equator, when and where there's less sunlight.
When you consider the fact that the gut - brain connection is recognized as a basic tenet of physiology and medicine, and that there's no shortage of evidence of gastrointestinal involvement in a variety of neurological diseases, it's easy to see how the balance of gut bacteria can play a significant role in your psychology and behavior as well.
This will not only contribute to your weight gain, but also increase your risk of many chronic illnesses, as leptin resistance plays a significant, if not primary, role in heart disease, obesity, diabetes, osteoporosis, autoimmune diseases, reproductive disorders, and perhaps the rate of aging itself.
Hormones also have a significant role in many diseases, like cancer and depression.
Other Benefits of Pomegranate: Anti-inflammatory: Like many chronic degenerative diseases, inflammation plays a significant role in cardiovascular disease pathogenesis.
There is increasing evidence that free radical - induced oxidative damage plays a significant role in the pathogenesis of Alzheimer's disease.
Cocoa is also one of the richest food sources of flavonoids, antioxidants which play a significant role in the prevention of certain diseases such as cancer and help fight against premature cell - ageing.
Cadmium is another toxic metal that plays a significant role in stimulating vascular disease.11 Cadmium is used in rechargeable batteries and during construction.
High leptin levels are very pro-inflammatory, and leptin also helps to mediate the manufacture of other very potent inflammatory chemicals from fat cells that also play a significant role in the progression of heart disease and diabetes.
One study showed that after a 3 day juice cleanse, participants showed significant changes in the intestinal microbiota that are associated with weight loss, decreased lipid oxidation (free radical damage), and higher levels of nitric oxide in the blood and urine which play a significant role in reducing cardiovascular disease.
For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseaseIn addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseasein the treatment of convulsion diseases.
If you are living with Herpes and looking to date, it is important what you say and how you say your partner about the disease plays a significant role in your dating.
Along with exercise, nutrition, and proper veterinary care, massage can play a significant role in keeping pets beginning to show joint stiffness, those with joint disease or congenital joint malformation mobile and comfortable.