Sentences with phrase «significant tumor response»

[31] Animal brain metastasis models have demonstrated significant tumor response and improved survival with this compound.

Not exact matches

Overall, the pathologic complete response rate was lower among women with at least one PIK3CA mutation in their tumor compared with women without a PIK3CA mutation, but the effect was only significant among the group of women with HER2 - and hormone receptor - positive breast cancer.

«Our results clearly demonstrate a significant, although unexpected, role for specific gut bacteria in enhancing the immune system's response to melanoma and possibly many other tumor types,» said study director Thomas Gajewski, MD, PhD, professor of medicine and pathology at the University of Chicago.

While much recent research has not been published in this area, there is actually a long history of studies that show: (1) there is a significant number of antigens shared between tumors and embryonic tissues (called «oncofetal antigens») and, consequently, antibodies made against tumors can also recognize embryonic tissues, and vice versa; (2) pregnancy confers some immunity against cancer (accompanied by antibody production against oncofetal antigens), not only against its occurrence but also against its growth; (3) similar to pregnancy, an immune response against cancer can be generated by vaccinating animals with embryonic tissues.

A significant amount of scientific data underlines that targeting the adenosine - cancer axis through the A2A receptor can promote anti-tumor immune responses and lead to tumor regression.

[66,67] Although responses were highly variable, patients with mutations more frequently achieved a clinical response than did those with amplifications, and patients with tumor mutations affecting exons 11 and 13 were able to achieve significant radiographic responses in over 40 % of cases.

However, there is significant variation between animals in their response to tumors and the probability of further tumor development.

However, there is significant variation between animals in their response to the tumors and therapy.