Sentences with phrase «significantly higher gene»

After a series of experiments, I was thrilled to be able to show that my optimisations achieved significantly higher gene transfer efficiency.

Not exact matches

Four genes were expressed at significantly higher levels in the blood of people who had been suicidal.

As the researchers showed, already at the age of six weeks the Igfbp2 gene exhibited higher levels of methylation, i.e. stronger epigenetic modification, and at the same time the IGFBP2 synthesis in the liver was significantly reduced.

Tissue taken from mice with the C. elegans gene had significantly higher levels of omega - 3 acids compared with that of normal animals, the team found.

The ACMG working group limited its list to genes that carry a high risk of disease — for example, mutations in BRCA1 and BRCA2, which significantly raise the risk of breast and ovarian cancer, and for which extra screening and prophylactic surgery can reduce risk.

Mesenchymal glioma stem cells show significantly higher radiation resistance and high expression of DNA - repair genes;

They found that the phages from antibiotic - treated mice carried significantly higher numbers of bacterial drug - resistance genes than they would have carried by chance.

Showed that the four genes that were significantly down - regulated have evolutionarily conserved miR -124-3p binding sites across a wide range of higher vertebrate species.

Apparently as a result, the 13 people they studied end up heavier and packed with a significantly higher percentage of body fat than family members with two normal copies of the leptin gene, the team reports in the 1 November issue of Nature.

This significantly increases the number of proteins a single gene codes for, and is thought to explain much of the complexity in higher - order organisms.

The study showed that mice lacking the SNRK gene had a significantly higher concentration of macrophages in white fat tissue compared with normal mice.

«We found significantly higher levels of metabolic gene activity in fish exposed to higher temperatures for two generations, indicating that shifts in energy production are central to maintaining performance at higher temperatures.»

A gene encoding a NAC TF with homology to ATAF2 from Arabidopsis was also expressed at significantly higher levels in bsl1 - 1.

Among the growth factors, expression of mRNA of genes that encode for GDNF, FGF2, GM - CSF and TGF - β1 was significantly higher in cumulus cells than in oocytes.

When they also looked for human genes with significantly higher or lower expression levels, they found 14 genes with increased expression and five with decreased expression.

Dr Gilchrist said: «This study suggests that we may improve significantly on the widely used analysis methods for determining gene expression levels from high throughput sequence data: absolute quantitation offers a much sounder basis for determining changes in gene expression level, a measure widely used to determine the consequence of genetic, chemical or physical disturbances in living systems.»

Excluding genes with homology evidence for immune function, 42.24 % of induced genes encode proteins with bioinformatic evidence for a signal peptide, a significantly higher fraction that the 15.95 % of non-induced and non-immune genes that encode a protein with bioinformatic evidence for a signal peptide (P = 3.4 × 10 − 15, Fisher's Exact Test).

Among the receptors, expression of mRNA of genes that encode for NTRK2, NGFRAP1, ESR1 and EDNRA was higher in cumulus cells, while oocytes had significantly higher expression of mRNA of genes that encode for IGF1R, ESR2 and TGF - βR3.

However, when we extracted gene expression levels from the brain transcriptome data following the methodology in Carneiro et al. [29], we found that levels of nucleotide diversity and the proportion of low frequency variants between lowly (bottom 5 %) and highly (top 5 %) expressed genes in our dataset (Table S7) were not significantly different in most comparisons (with the exception of π in O. c. cuniculus) nor did they consistently differ in the expected direction when assuming higher error rates in lowly expressed genes.

Vomeronasal receptor (A) and olfactory receptor genes (B) annotated as functional (black) are expressed at significantly higher levels than those annotated as nonfunctional pseudogenes (grey).

Most of these genes were significantly down - regulated in both V + fractions and remain high in the V − S − fraction, indicating that this fraction contained a significant proportion of undifferentiated ES cells.

Genetic variants in highly penetrant genes (BRCA1 and BRCA2) confer a significantly higher risk of being diagnosed with breast cancer, while changes in other genes have a more moderate impact on risk.

First Major Gene Mutation for Hereditary Prostate Cancer Found After a 20 - year quest to find a genetic driver for prostate cancer that strikes men at younger ages and runs in families, researchers have identified a rare, inherited mutation linked to a significantly higher risk of the disease.

Comparison of gene expression profiles indicate that both the SLC2A1 and CLICl receptor subunit transcripts are expressed at significantly higher levels in NSCs but not in differentiated neurons, suggesting that NSCs may be more sensitive to the channel - effects of amiodarone HCL.

If we have changes in them called mutations, and if the mutation significantly increase the risk of a disease (as compared to someone who does not have a mutation in the gene), it is called a high - risk gene.

No single non-synonymous (NS) single nucleotide variant (SNV) nor any gene carrying a higher burden of NS SNVs was significantly associated with PD status after multiple - testing correction.

+ / + - Homozygotes for this variant allele in the CTH gene had significantly higher plasma homocysteine levels than other genotypes in a cohort of 496 Caucasian individuals.

Recognizing that no dog is genetically perfect; that maintaining a rich and diverse gene pool is important for the long - term health of the breed; and that good breeding decisions must balance many factors, it is suggested that breeders give the highest health priority to selection against heritable disorders that significantly decrease quality of life and that have the greatest likelihood for improvement through careful breeding decisions.